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AIP aryl hydrocarbon receptor interacting protein [ Homo sapiens (human) ]

Gene ID: 9049, updated on 10-Dec-2024

Summary

Official Symbol
AIPprovided by HGNC
Official Full Name
aryl hydrocarbon receptor interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:358
See related
Ensembl:ENSG00000110711 MIM:605555; AllianceGenome:HGNC:358
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARA9; XAP2; PITA1; XAP-2; FKBP16; FKBP37; SMTPHN
Summary
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in lymph node (RPKM 29.1), spleen (RPKM 26.1) and 25 other tissues See more
Orthologs
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Genomic context

See AIP in Genome Data Viewer
Location:
11q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (67483026..67491103)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (67462305..67485230)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67250497..67258574)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 152 Neighboring gene calcium binding protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5103 Neighboring gene transmembrane protein 134 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:67236334-67236958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5104 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:67244852-67245402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67253051-67254024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5108 Neighboring gene microRNA 6752 Neighboring gene phosphatidylinositol transfer protein membrane associated 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67270543-67271292 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67271293-67272042 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3641 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3643 Neighboring gene cyclin dependent kinase 2 associated protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GAF domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables aryl hydrocarbon receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of aryl hydrocarbon receptor complex IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
AH receptor-interacting protein
Names
Ah receptor activated 9
FK506-binding protein 37
FKBP prolyl isomerase 16
HBV X-associated protein 2
X-associated protein-2
aryl hydrocarbon receptor-associated protein 9
hepatitis B virus X-associated cellular protein 2
immunophilin homolog ARA9
NP_001289888.1
NP_001289889.1
NP_003968.3
XP_054226424.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008969.1 RefSeqGene

    Range
    4996..13075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_460

mRNA and Protein(s)

  1. NM_001302959.2NP_001289888.1  AH receptor-interacting protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in place of the first exon in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    BQ054206, U31913, U78521
    Consensus CDS
    CCDS91516.1
    UniProtKB/TrEMBL
    A0A804HKK3, A0A804HKL7
    Related
    ENSP00000507979.1, ENST00000683856.1
    Conserved Domains (1) summary
    sd00006
    Location:124166
    TPR; TPR repeat [structural motif]
  2. NM_001302960.2NP_001289889.1  AH receptor-interacting protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction in the 3' end of the coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AP003419, BQ420398, HY065637, U31913, U78521
    Consensus CDS
    CCDS91515.1
    UniProtKB/TrEMBL
    A0A804HIX8, A0A804HJ38
    Related
    ENSP00000507343.1, ENST00000683237.1
    Conserved Domains (1) summary
    cl19519
    Location:2990
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
  3. NM_003977.4NP_003968.3  AH receptor-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_003968.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AP003419, HY065637, U31913, U78521
    Consensus CDS
    CCDS8168.1
    UniProtKB/Swiss-Prot
    A0SZW3, A0SZW4, A0SZW5, A0SZW6, G9I2H4, O00170, Q2M3Q2, Q99606
    UniProtKB/TrEMBL
    C0JXB9, C8CHN4, C8CK04, C8CK05, D0EKE4, D0EKE6, D5LTB3
    Related
    ENSP00000279146.3, ENST00000279146.8
    Conserved Domains (2) summary
    sd00006
    Location:183225
    TPR; TPR repeat [structural motif]
    cl19519
    Location:2990
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    67483026..67491103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    67462305..67485230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370449.1XP_054226424.1  AH receptor-interacting protein isoform X1

    UniProtKB/TrEMBL
    B7SBB1