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AIP aryl hydrocarbon receptor interacting protein [ Homo sapiens (human) ]

Gene ID: 9049, updated on 24-Nov-2020

Summary

Official Symbol
AIPprovided by HGNC
Official Full Name
aryl hydrocarbon receptor interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:358
See related
Ensembl:ENSG00000110711 MIM:605555
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARA9; XAP2; PITA1; XAP-2; FKBP16; FKBP37; SMTPHN
Summary
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in lymph node (RPKM 29.1), spleen (RPKM 26.1) and 25 other tissues See more
Orthologs

Genomic context

See AIP in Genome Data Viewer
Location:
11q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (67468179..67491103)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67250505..67258579)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type C associated protein Neighboring gene coronin 1B Neighboring gene G protein-coupled receptor 152 Neighboring gene calcium binding protein 4 Neighboring gene transmembrane protein 134 Neighboring gene microRNA 6752 Neighboring gene phosphatidylinositol transfer protein membrane associated 1 Neighboring gene cyclin dependent kinase 2 associated protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GAF domain binding IDA
Inferred from Direct Assay
more info
PubMed 
aryl hydrocarbon receptor binding IEA
Inferred from Electronic Annotation
more info
 
peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
transcription factor binding TAS
Traceable Author Statement
more info
PubMed 
unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
protein maturation by protein folding IDA
Inferred from Direct Assay
more info
PubMed 
protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
 
protein targeting to mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein kinase A signaling IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
aryl hydrocarbon receptor complex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
AH receptor-interacting protein
Names
Ah receptor activated 9
FK506-binding protein 37
FKBP prolyl isomerase 16
HBV X-associated protein 2
X-associated protein-2
aryl hydrocarbon receptor-associated protein 9
hepatitis B virus X-associated cellular protein 2
immunophilin homolog ARA9
NP_001289888.1
NP_001289889.1
NP_003968.3
XP_024304529.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008969.1 RefSeqGene

    Range
    4996..13075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_460

mRNA and Protein(s)

  1. NM_001302959.2NP_001289888.1  AH receptor-interacting protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in place of the first exon in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    BQ054206, U31913, U78521
    UniProtKB/Swiss-Prot
    O00170
    Conserved Domains (1) summary
    sd00006
    Location:124166
    TPR; TPR repeat [structural motif]
  2. NM_001302960.2NP_001289889.1  AH receptor-interacting protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction in the 3' end of the coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AP003419, BQ420398, HY065637, U31913, U78521
    UniProtKB/Swiss-Prot
    O00170
    Conserved Domains (1) summary
    cl19519
    Location:2990
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
  3. NM_003977.4NP_003968.3  AH receptor-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_003968.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AP003419, HY065637, U31913, U78521
    Consensus CDS
    CCDS8168.1
    UniProtKB/Swiss-Prot
    O00170
    UniProtKB/TrEMBL
    G9I2H4
    Related
    ENSP00000279146.3, ENST00000279146.8
    Conserved Domains (2) summary
    sd00006
    Location:183225
    TPR; TPR repeat [structural motif]
    cl19519
    Location:2990
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    67468179..67491103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448761.1XP_024304529.1  AH receptor-interacting protein isoform X1

    Conserved Domains (2) summary
    sd00006
    Location:183225
    TPR; TPR repeat [structural motif]
    cl19519
    Location:2990
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
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