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GADD45GIP1 GADD45G interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 90480, updated on 7-Oct-2018


Official Symbol
GADD45GIP1provided by HGNC
Official Full Name
GADD45G interacting protein 1provided by HGNC
Primary source
See related
Ensembl:ENSG00000179271 MIM:605162; Vega:OTTHUMG00000180724
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRG6; CRIF1; PLINP; CKBBP2; Plinp1; MRP-L59; PLINP-1; CKbetaBP2
This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]
Ubiquitous expression in kidney (RPKM 22.3), fat (RPKM 19.9) and 25 other tissues See more

Genomic context

See GADD45GIP1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (12954156..12957254, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13064970..13068068, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene microRNA 6515 Neighboring gene calreticulin Neighboring gene RAD23 homolog A, nucleotide excision repair protein Neighboring gene DAN domain BMP antagonist family member 5 Neighboring gene nuclear factor I X Neighboring gene uncharacterized LOC107985286

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016


GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?



Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.

Pathways from BioSystems

  • Mitochondrial translation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
  • Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
  • Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
  • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
    Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC4667, MGC4758

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
mitochondrial translational termination TAS
Traceable Author Statement
more info
mitotic cell cycle arrest IDA
Inferred from Direct Assay
more info
viral process IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
mitochondrion IDA
Inferred from Direct Assay
more info
nucleus IEA
Inferred from Electronic Annotation
more info
ribosome IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
growth arrest and DNA damage-inducible proteins-interacting protein 1
39S ribosomal protein L59, mitochondrial
CKII beta binding protein 2
CKII beta-associating protein
CR6 interacting factor 1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
growth arrest- and DNA damage-inducible GADD45G-interacting protein
mitochondrial large ribosomal subunit protein CRIF1
mitochondrial large ribosomal subunit protein mL64
p53-responsive gene 6 protein
papillomavirus L2 interacting nuclear protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052850.3NP_443082.2  growth arrest and DNA damage-inducible proteins-interacting protein 1

    See identical proteins and their annotated locations for NP_443082.2

    Status: REVIEWED

    Source sequence(s)
    AF479749, AI309741, BI459923
    Consensus CDS
    ENSP00000323065.1, OTTHUMP00000265099, ENST00000316939.2, OTTHUMT00000452759
    Conserved Domains (1) summary
    CR6_interact; Growth arrest and DNA-damage-inducible proteins-interacting protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly


  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    12954156..12957254 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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