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ERI1 exoribonuclease 1 [ Homo sapiens (human) ]

Gene ID: 90459, updated on 1-Aug-2020

Summary

Official Symbol
ERI1provided by HGNC
Official Full Name
exoribonuclease 1provided by HGNC
Primary source
HGNC:HGNC:23994
See related
Ensembl:ENSG00000104626 MIM:608739
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEXO; THEX1; 3'HEXO
Expression
Ubiquitous expression in testis (RPKM 5.2), appendix (RPKM 4.2) and 25 other tissues See more
Orthologs

Genomic context

See ERI1 in Genome Data Viewer
Location:
8p23.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (8892225..9100262)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (8860314..8890849)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379225 Neighboring gene claudin 23 Neighboring gene malignant fibrous histiocytoma amplified sequence 1 Neighboring gene RNA, U6 small nuclear 682, pseudogene Neighboring gene MRPS18C pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 10847 Neighboring gene ribosomal protein L10 pseudogene 19 Neighboring gene uncharacterized LOC105379227 Neighboring gene microRNA 4660 Neighboring gene small nucleolar RNA, C/D box 3I Neighboring gene RNA, U7 small nuclear 55 pseudogene Neighboring gene uncharacterized LOC102724880 Neighboring gene protein phosphatase 1 regulatory subunit 3B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
NHGRI GWA Catalog
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC35395

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5' exonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
3'-5'-exoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3'-5'-exoribonuclease activity TAS
Traceable Author Statement
more info
 
histone pre-mRNA stem-loop binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
rRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
DNA catabolic process, exonucleolytic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gene silencing by RNA IEA
Inferred from Electronic Annotation
more info
 
NOT histone mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA 3'-end processing ISS
Inferred from Sequence or Structural Similarity
more info
 
rRNA processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
histone pre-mRNA 3'end processing complex ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
3'-5' exoribonuclease 1
Names
3' exoribonuclease
3'-5' exonuclease ERI1
enhanced RNAi three prime mRNA exonuclease homolog 1
histone mRNA 3' end-specific exonuclease
histone mRNA 3'-end-specific exoribonuclease
histone mRNA 3'-exonuclease 1
three prime histone mRNA exonuclease 1
three prime mRNA exonuclease 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354635.2NP_001341564.1  3'-5' exoribonuclease 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087579, AC087763
    Conserved Domains (2) summary
    cd06133
    Location:52232
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    pfam02037
    Location:132
    SAP; SAP domain
  2. NM_001354636.2NP_001341565.1  3'-5' exoribonuclease 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087579, AC087763
    Conserved Domains (1) summary
    cd06133
    Location:15195
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  3. NM_001354638.2NP_001341567.1  3'-5' exoribonuclease 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087579, AC087763
    Conserved Domains (2) summary
    cd06133
    Location:130273
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    pfam02037
    Location:76110
    SAP; SAP domain
  4. NM_153332.4NP_699163.2  3'-5' exoribonuclease 1 isoform 1

    See identical proteins and their annotated locations for NP_699163.2

    Status: VALIDATED

    Source sequence(s)
    AC087579, AV709794, BC035279
    Consensus CDS
    CCDS5972.1
    UniProtKB/Swiss-Prot
    Q8IV48
    UniProtKB/TrEMBL
    A0A024R355
    Related
    ENSP00000250263.7, ENST00000250263.8
    Conserved Domains (2) summary
    cd06133
    Location:130310
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    pfam02037
    Location:76110
    SAP; SAP domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    8892225..9100262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013949.1XP_016869438.1  3'-5' exoribonuclease 1 isoform X1

  2. XM_017013951.1XP_016869440.1  3'-5' exoribonuclease 1 isoform X1

  3. XM_011543849.2XP_011542151.1  3'-5' exoribonuclease 1 isoform X2

    Conserved Domains (2) summary
    cd06133
    Location:130269
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    pfam02037
    Location:76110
    SAP; SAP domain
  4. XM_005272401.3XP_005272458.1  3'-5' exoribonuclease 1 isoform X3

    See identical proteins and their annotated locations for XP_005272458.1

    Conserved Domains (2) summary
    cd06133
    Location:52232
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    pfam02037
    Location:132
    SAP; SAP domain
  5. XM_024447323.1XP_024303091.1  3'-5' exoribonuclease 1 isoform X4

    Conserved Domains (1) summary
    cd06133
    Location:15195
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
  6. XM_017013952.2XP_016869441.1  3'-5' exoribonuclease 1 isoform X3

    Conserved Domains (2) summary
    cd06133
    Location:52232
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    pfam02037
    Location:132
    SAP; SAP domain
  7. XM_017013955.2XP_016869444.1  3'-5' exoribonuclease 1 isoform X5

  8. XM_011543850.3XP_011542152.1  3'-5' exoribonuclease 1 isoform X3

    See identical proteins and their annotated locations for XP_011542152.1

    Conserved Domains (2) summary
    cd06133
    Location:52232
    ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    pfam02037
    Location:132
    SAP; SAP domain

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p13 PATCHES

    Range
    4251550..4349048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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