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RPL14 ribosomal protein L14 [ Homo sapiens (human) ]

Gene ID: 9045, updated on 5-Jan-2020

Summary

Official Symbol
RPL14provided by HGNC
Official Full Name
ribosomal protein L14provided by HGNC
Primary source
HGNC:HGNC:10305
See related
Ensembl:ENSG00000188846 MIM:617414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L14; RL14; hRL14; CTG-B33; CAG-ISL-7
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 576.2), lymph node (RPKM 328.7) and 25 other tissues See more
Orthologs

Genomic context

See RPL14 in Genome Data Viewer
Location:
3p22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (40457339..40468587)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (40498783..40503863)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene phosphoglycerate mutase 1 pseudogene 3 Neighboring gene ENTPD3 antisense RNA 1 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 3 Neighboring gene Sharpr-MPRA regulatory region 7904 Neighboring gene zinc finger protein 619 Neighboring gene RNA, U5B small nuclear 2, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L14 (RPL14), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L14 (RPL14), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L14 (RPL14), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L14 (RPL14), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of ribosomal protein L14 (RPL14) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC88594

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
postsynaptic density EXP
Inferred from Experiment
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L14
Names
large ribosomal subunit protein eL14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034996.3NP_001030168.1  60S ribosomal protein L14

    See identical proteins and their annotated locations for NP_001030168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC104186, BC005134, BC029036, BU686905, CD298951
    Consensus CDS
    CCDS43070.1
    UniProtKB/Swiss-Prot
    P50914
    Related
    ENSP00000379506.2, ENST00000396203.7
    Conserved Domains (3) summary
    PTZ00065
    Location:2128
    PTZ00065; 60S ribosomal protein L14; Provisional
    cd06088
    Location:781
    KOW_RPL14; KOW motif of Ribosomal Protein L14
    pfam01929
    Location:47120
    Ribosomal_L14e; Ribosomal protein L14
  2. NM_003973.5NP_003964.3  60S ribosomal protein L14

    See identical proteins and their annotated locations for NP_003964.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5'-terminal exon, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC104186, BC000606, BC005134, BU686905
    Consensus CDS
    CCDS33739.1
    UniProtKB/Swiss-Prot
    P50914
    Related
    ENSP00000345156.6, ENST00000338970.10
    Conserved Domains (3) summary
    PTZ00065
    Location:2128
    PTZ00065; 60S ribosomal protein L14; Provisional
    cd06088
    Location:781
    KOW_RPL14; KOW motif of Ribosomal Protein L14
    pfam01929
    Location:47120
    Ribosomal_L14e; Ribosomal protein L14

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    40457339..40468587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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