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BTAF1 B-TFIID TATA-box binding protein associated factor 1 [ Homo sapiens (human) ]

Gene ID: 9044, updated on 5-Sep-2021

Summary

Official Symbol
BTAF1provided by HGNC
Official Full Name
B-TFIID TATA-box binding protein associated factor 1provided by HGNC
Primary source
HGNC:HGNC:17307
See related
Ensembl:ENSG00000095564 MIM:605191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOT1; TAF172; TAFII170; TAF(II)170
Summary
This gene encodes a TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II. This TAF has DNA-dependent ATPase activity, which drives the dissociation of TBP from DNA, freeing the TBP to associate with other TATA boxes or TATA-less promoters. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in skin (RPKM 23.9), lymph node (RPKM 17.7) and 25 other tissues See more
Orthologs
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Genomic context

See BTAF1 in Genome Data Viewer
Location:
10q23.32
Exon count:
44
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (91923770..92031437)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (93683527..93791194)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene tankyrase 2 Neighboring gene signal recognition particle 9 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 9903 Neighboring gene fibroblast growth factor binding protein 3 Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene uncharacterized LOC107984254 Neighboring gene succinate dehydrogenase complex subunit C pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed
tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0940, MGC138406

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables TBP-class protein binding IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
TATA-binding protein-associated factor 172
Names
ATP-dependent helicase BTAF1
B-TFIID transcription factor-associated 170 kDa subunit
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)
Mot1 homolog
TBP-associated factor 172

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003972.3NP_003963.1  TATA-binding protein-associated factor 172

    See identical proteins and their annotated locations for NP_003963.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AF038362, AL365398, DB164703
    Consensus CDS
    CCDS7419.1
    UniProtKB/Swiss-Prot
    O14981
    UniProtKB/TrEMBL
    Q2M1V9, Q8N6J1
    Related
    ENSP00000265990.6, ENST00000265990.11
    Conserved Domains (3) summary
    COG0553
    Location:12361801
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    sd00044
    Location:352377
    HEAT; HEAT repeat [structural motif]
    pfam12054
    Location:5941051
    DUF3535; Domain of unknown function (DUF3535)

RNA

  1. NR_165090.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL359198, AL365398
  2. NR_165091.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL359198, AL365398
  3. NR_165092.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL359198, AL365398
  4. NR_165093.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL359198, AL365398
  5. NR_165094.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL359198, AL365398
  6. NR_165095.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL359198, AL365398
  7. NR_165096.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL359198, AL365398
  8. NR_165097.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL359198, AL365398
  9. NR_165098.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL359198, AL365398
  10. NR_165099.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL359198, AL365398
  11. NR_165101.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL359198, AL365398
  12. NR_165102.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL359198, AL365398
  13. NR_165103.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL359198, AL365398
  14. NR_165104.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL359198, AL365398

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    91923770..92031437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540326.2XP_011538628.1  TATA-binding protein-associated factor 172 isoform X1

    Conserved Domains (5) summary
    COG0553
    Location:11991764
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    COG1413
    Location:259554
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:352377
    HEAT; HEAT repeat [structural motif]
    cd17999
    Location:12291466
    DEXHc_Mot1; DEXH-box helicase domain of Mot1
    pfam12054
    Location:5491014
    DUF3535; Domain of unknown function (DUF3535)
  2. XM_017016877.1XP_016872366.1  TATA-binding protein-associated factor 172 isoform X2

  3. XM_011540327.2XP_011538629.1  TATA-binding protein-associated factor 172 isoform X3

    Conserved Domains (4) summary
    COG0553
    Location:11121677
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    sd00044
    Location:228253
    HEAT; HEAT repeat [structural motif]
    cd17999
    Location:11421379
    DEXHc_Mot1; DEXH-box helicase domain of Mot1
    pfam12054
    Location:462927
    DUF3535; Domain of unknown function (DUF3535)
  4. XM_011540328.2XP_011538630.1  TATA-binding protein-associated factor 172 isoform X4

    Conserved Domains (4) summary
    COG0553
    Location:10801645
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    sd00044
    Location:196221
    HEAT; HEAT repeat [structural motif]
    cd17999
    Location:11101347
    DEXHc_Mot1; DEXH-box helicase domain of Mot1
    pfam12054
    Location:430895
    DUF3535; Domain of unknown function (DUF3535)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_165100.1: Suppressed sequence

    Description
    NR_165100.1: This RefSeq was removed because it was a duplicate of NR_165099.1.
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