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MED30 mediator complex subunit 30 [ Homo sapiens (human) ]

Gene ID: 90390, updated on 7-Jun-2020

Summary

Official Symbol
MED30provided by HGNC
Official Full Name
mediator complex subunit 30provided by HGNC
Primary source
HGNC:HGNC:23032
See related
Ensembl:ENSG00000164758 MIM:610237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MED30S; THRAP6; TRAP25
Summary
The multiprotein TRAP/Mediator complex facilitates gene expression through a wide variety of transcriptional activators. MED30 is a component of this complex that appears to be metazoan specific (Baek et al., 2002 [PubMed 11909976]).[supplied by OMIM, Nov 2010]
Expression
Ubiquitous expression in bone marrow (RPKM 9.2), lymph node (RPKM 5.0) and 24 other tissues See more
Orthologs

Genomic context

See MED30 in Genome Data Viewer
Location:
8q24.11
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (117520713..117540262)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (118532532..118552510)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 member 8 Neighboring gene uncharacterized LOC105375716 Neighboring gene RNA, 7SL, cytoplasmic 826, pseudogene Neighboring gene uncharacterized LOC105375717 Neighboring gene uncharacterized LOC105375721 Neighboring gene ribosomal protein S10 pseudogene 16 Neighboring gene uncharacterized LOC107986970

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 30 (MED30) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat SiRNA knockdown of d MED30 shows a modest inhibition in HIV-1 Tat-mediated transcription levels as compared to control PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9890

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nuclear receptor transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coregulator activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
vitamin D receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription initiation from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 30
Names
TRAP/Mediator complex component TRAP25
putative mediator of RNA polymerase II transcription subunit 30
thyroid hormone receptor-associated protein 6
thyroid hormone receptor-associated protein complex 25 kDa component

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282986.1NP_001269915.1  mediator of RNA polymerase II transcription subunit 30 isoform 2

    See identical proteins and their annotated locations for NP_001269915.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoofrm 1.
    Source sequence(s)
    AA812233, AC024329, AC087361, FM179284
    Consensus CDS
    CCDS64959.1
    UniProtKB/Swiss-Prot
    Q96HR3
    Related
    ENSP00000431051.1, ENST00000522839.1
    Conserved Domains (1) summary
    pfam11315
    Location:29141
    Med30; Mediator complex subunit 30
  2. NM_001363182.2NP_001350111.1  mediator of RNA polymerase II transcription subunit 30 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC024329, AC087361, AY083305
    Conserved Domains (1) summary
    pfam11315
    Location:29147
    Med30; Mediator complex subunit 30
  3. NM_080651.4NP_542382.1  mediator of RNA polymerase II transcription subunit 30 isoform 1

    See identical proteins and their annotated locations for NP_542382.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest isoform (1).
    Source sequence(s)
    AA812233, AC024329, AC087361, AY083305
    Consensus CDS
    CCDS6323.1
    UniProtKB/Swiss-Prot
    Q96HR3
    Related
    ENSP00000297347.3, ENST00000297347.7
    Conserved Domains (1) summary
    pfam11315
    Location:29176
    Med30; Mediator complex subunit 30

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    117520713..117540262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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