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TICRR TOPBP1 interacting checkpoint and replication regulator [ Homo sapiens (human) ]

Gene ID: 90381, updated on 9-Jun-2020

Summary

Official Symbol
TICRRprovided by HGNC
Official Full Name
TOPBP1 interacting checkpoint and replication regulatorprovided by HGNC
Primary source
HGNC:HGNC:28704
See related
Ensembl:ENSG00000140534 MIM:613298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLD3; Treslin; C15orf42
Summary
Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]
Expression
Broad expression in bone marrow (RPKM 1.6), testis (RPKM 1.3) and 20 other tissues See more
Orthologs

Genomic context

See TICRR in Genome Data Viewer
Location:
15q26.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (89575469..89628023)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90118818..90171254)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Rh family C glycoprotein Neighboring gene long intergenic non-protein coding RNA 928 Neighboring gene kinesin family member 7 Neighboring gene perilipin 1 Neighboring gene ribosomal protein L36a pseudogene 43 Neighboring gene peroxisomal biogenesis factor 11 alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41618, MGC45866

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic DNA replication checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic DNA replication checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic G2 DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of DNA-dependent DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of DNA-dependent DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ionizing radiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
treslin
Names
topBP1-interacting checkpoint and replication regulator
topBP1-interacting replication-stimulating protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308025.1NP_001294954.1  treslin isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)
    Source sequence(s)
    AC013787, AW627706, GQ227787
    Consensus CDS
    CCDS76791.1
    UniProtKB/Swiss-Prot
    Q7Z2Z1
    Related
    ENSP00000453306.1, ENST00000560985.5
    Conserved Domains (1) summary
    pfam15292
    Location:2081003
    Treslin_N; Treslin N-terminus
  2. NM_152259.4NP_689472.3  treslin isoform 2

    See identical proteins and their annotated locations for NP_689472.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC013391, AK123612, AW627706, BX538335, CN285632, DR731357, DR731358
    Consensus CDS
    CCDS10352.2
    UniProtKB/Swiss-Prot
    Q7Z2Z1
    Related
    ENSP00000268138.7, ENST00000268138.12
    Conserved Domains (1) summary
    pfam15292
    Location:2081004
    Treslin_N; Treslin N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    89575469..89628023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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