Format

Send to:

Choose Destination

CTU1 cytosolic thiouridylase subunit 1 [ Homo sapiens (human) ]

Gene ID: 90353, updated on 1-Jun-2020

Summary

Official Symbol
CTU1provided by HGNC
Official Full Name
cytosolic thiouridylase subunit 1provided by HGNC
Primary source
HGNC:HGNC:29590
See related
Ensembl:ENSG00000142544 MIM:612694
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCS6; ATPBD3
Expression
Ubiquitous expression in kidney (RPKM 1.5), spleen (RPKM 1.3) and 25 other tissues See more
Orthologs

Genomic context

See CTU1 in Genome Data Viewer
Location:
19q13.41
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (51097606..51108409, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51600863..51611647, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985341 Neighboring gene kallikrein related peptidase 14 Neighboring gene sialic acid binding Ig like lectin 18, pseudogene Neighboring gene sialic acid binding Ig like lectin 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC17332

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
protein urmylation IEA
Inferred from Electronic Annotation
more info
 
tRNA modification TAS
Traceable Author Statement
more info
 
tRNA thio-modification NAS
Non-traceable Author Statement
more info
PubMed 
tRNA wobble position uridine thiolation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA wobble uridine modification NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic tRNA wobble base thiouridylase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytoplasmic tRNA 2-thiolation protein 1
Names
ATP binding domain 3
ATP-binding domain-containing protein 3
cancer-associated gene protein
cancer-associated protein
cytoplasmic tRNA adenylyltransferase 1
cytosolic thiouridylase subunit 1 homolog
NP_660275.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145232.4NP_660275.2  cytoplasmic tRNA 2-thiolation protein 1

    See identical proteins and their annotated locations for NP_660275.2

    Status: VALIDATED

    Source sequence(s)
    AC011473, AK291173, BX440723
    Consensus CDS
    CCDS12824.1
    UniProtKB/Swiss-Prot
    Q7Z7A3
    Related
    ENSP00000390011.1, ENST00000421832.3
    Conserved Domains (3) summary
    TIGR00269
    Location:207308
    TIGR00269; TIGR00269 family protein
    COG0037
    Location:54322
    TilS; tRNA(Ile)-lysidine synthase TilS/MesJ [Translation, ribosomal structure and biogenesis]
    cd01993
    Location:54243
    Alpha_ANH_like_II; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    51097606..51108409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center