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CCRL2 C-C motif chemokine receptor like 2 [ Homo sapiens (human) ]

Gene ID: 9034, updated on 10-Dec-2019

Summary

Official Symbol
CCRL2provided by HGNC
Official Full Name
C-C motif chemokine receptor like 2provided by HGNC
Primary source
HGNC:HGNC:1612
See related
Ensembl:ENSG00000121797 MIM:608379
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCR; CKRX; CRAM; ACKR5; CRAM-A; CRAM-B
Summary
This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 6.4), lung (RPKM 6.3) and 20 other tissues See more
Orthologs

Genomic context

See CCRL2 in Genome Data Viewer
Location:
3p21.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (46407166..46409523)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (46448721..46454488)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine receptor 2 Neighboring gene CCR5 antisense RNA Neighboring gene C-C motif chemokine receptor 5 (gene/pseudogene) Neighboring gene long intergenic non-protein coding RNA 2009 Neighboring gene lactotransferrin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study implicates PARD3B-based AIDS restriction.
NHGRI GWA Catalog
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
NHGRI GWA Catalog
Multiple common variants for celiac disease influencing immune gene expression.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of chemokine (C-C motif) receptor-like 2 (CCRL2) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
    Chemokine receptors bind chemokines, organism-specific biosystemChemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of i...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ55815, MGC34104, MGC116710

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CCR chemokine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine receptor activity TAS
Traceable Author Statement
more info
PubMed 
chemokine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
C-C chemokine receptor-like 2
Names
atypical chemokine receptor 5
chemokine (C-C motif) receptor-like 2
chemokine receptor CCR11
chemokine receptor X
putative MCP-1 chemokine receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130910.2NP_001124382.1  C-C chemokine receptor-like 2 isoform 2

    See identical proteins and their annotated locations for NP_001124382.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1, resulting in a longer isoform (2) that has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC098613, AF015524, AK296673
    Consensus CDS
    CCDS46814.1
    UniProtKB/Swiss-Prot
    O00421
    Related
    ENSP00000349967.4, ENST00000357392.4
    Conserved Domains (1) summary
    PHA03087
    Location:34333
    PHA03087; G protein-coupled chemokine receptor-like protein; Provisional
  2. NM_003965.5NP_003956.2  C-C chemokine receptor-like 2 isoform 1

    See identical proteins and their annotated locations for NP_003956.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript but encodes the longer isoform (1).
    Source sequence(s)
    AF015525, BC071682
    Consensus CDS
    CCDS43079.1
    UniProtKB/Swiss-Prot
    O00421
    UniProtKB/TrEMBL
    B2R8C0
    Related
    ENSP00000381994.3, ENST00000399036.4
    Conserved Domains (1) summary
    PHA03087
    Location:22321
    PHA03087; G protein-coupled chemokine receptor-like protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    46407166..46409523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534209.1XP_011532511.1  C-C chemokine receptor-like 2 isoform X1

    See identical proteins and their annotated locations for XP_011532511.1

    UniProtKB/Swiss-Prot
    O00421
    UniProtKB/TrEMBL
    B2R8C0
    Conserved Domains (1) summary
    PHA03087
    Location:22321
    PHA03087; G protein-coupled chemokine receptor-like protein; Provisional
  2. XM_017007436.1XP_016862925.1  C-C chemokine receptor-like 2 isoform X1

    UniProtKB/Swiss-Prot
    O00421
    UniProtKB/TrEMBL
    B2R8C0
    Related
    ENSP00000383677.3, ENST00000400880.3
    Conserved Domains (1) summary
    PHA03087
    Location:22321
    PHA03087; G protein-coupled chemokine receptor-like protein; Provisional
  3. XM_011534208.1XP_011532510.1  C-C chemokine receptor-like 2 isoform X1

    See identical proteins and their annotated locations for XP_011532510.1

    UniProtKB/Swiss-Prot
    O00421
    UniProtKB/TrEMBL
    B2R8C0
    Conserved Domains (1) summary
    PHA03087
    Location:22321
    PHA03087; G protein-coupled chemokine receptor-like protein; Provisional
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