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ZNF160 zinc finger protein 160 [ Homo sapiens (human) ]

Gene ID: 90338, updated on 23-Nov-2021

Summary

Official Symbol
ZNF160provided by HGNC
Official Full Name
zinc finger protein 160provided by HGNC
Primary source
HGNC:HGNC:12948
See related
Ensembl:ENSG00000170949 MIM:600398
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
F11; HZF5; KR18; HKr18
Summary
The protein encoded by this gene is a Kruppel-related zinc finger protein which is characterized by the presence of an N-terminal repressor domain, the Kruppel-associated box (KRAB). The KRAB domain is a potent repressor of transcription; thus this protein may function in transcription regulation. Multiple transcript variants have been found for this gene. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in spleen (RPKM 7.4), adrenal (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF160 in Genome Data Viewer
Location:
19q13.41-q13.42
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (53066614..53103422, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53569867..53606675, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene endogenous retrovirus group V member 1, envelope Neighboring gene endogenous retrovirus group V member 2, envelope Neighboring gene zinc finger protein 415 Neighboring gene zinc finger protein 347 Neighboring gene Sharpr-MPRA regulatory region 171

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00032, KIAA1611, DKFZp686B16128

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in hemopoiesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 160
Names
KRAB zinc finger protein KR18
zinc finger protein 5
zinc finger protein HZF5
zinc finger protein Kr18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102603.2NP_001096073.1  zinc finger protein 160 isoform a

    See identical proteins and their annotated locations for NP_001096073.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 1-2, and 4-12, encodes isoform (a).
    Source sequence(s)
    AC010328, BC094880, DA230397
    Consensus CDS
    CCDS12859.1
    UniProtKB/Swiss-Prot
    Q9HCG1
    UniProtKB/TrEMBL
    A0A024R4Q2
    Related
    ENSP00000406201.1, ENST00000429604.5
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:367810
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:623643
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:257279
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:691715
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001322125.2NP_001309054.1  zinc finger protein 160 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) and variant 17 both encode isoform c.
    Source sequence(s)
    AC010328
    Consensus CDS
    CCDS82392.1
    UniProtKB/Swiss-Prot
    Q9HCG1
    Conserved Domains (2) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    pfam01352
    Location:847
    KRAB; KRAB box
  3. NM_001322126.2NP_001309055.1  zinc finger protein 160 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) and variant 16 both encode isoform c.
    Source sequence(s)
    AC010328, BC000807
    Consensus CDS
    CCDS82392.1
    UniProtKB/Swiss-Prot
    Q9HCG1
    Related
    ENSP00000347273.4, ENST00000355147.9
    Conserved Domains (2) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    pfam01352
    Location:847
    KRAB; KRAB box
  4. NM_001322128.2NP_001309057.1  zinc finger protein 160 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 1-3 and 5-12, encodes isoform (a).
    Source sequence(s)
    AC010328
    Consensus CDS
    CCDS12859.1
    UniProtKB/Swiss-Prot
    Q9HCG1
    UniProtKB/TrEMBL
    A0A024R4Q2
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:367810
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:623643
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:257279
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:691715
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001322129.2NP_001309058.1  zinc finger protein 160 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1-4 and 6-12, encodes isoform (a).
    Source sequence(s)
    AC010328
    Consensus CDS
    CCDS12859.1
    UniProtKB/Swiss-Prot
    Q9HCG1
    UniProtKB/TrEMBL
    A0A024R4Q2
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:367810
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:623643
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:257279
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:691715
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001322130.2NP_001309059.1  zinc finger protein 160 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1-5 and 7-12, encodes isoform (a).
    Source sequence(s)
    AC010328
    Consensus CDS
    CCDS12859.1
    UniProtKB/Swiss-Prot
    Q9HCG1
    UniProtKB/TrEMBL
    A0A024R4Q2
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:367810
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:623643
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:257279
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:691715
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001322131.2NP_001309060.1  zinc finger protein 160 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 1-6 and 8-12, encodes isoform (a).
    Source sequence(s)
    AC010328
    Consensus CDS
    CCDS12859.1
    UniProtKB/Swiss-Prot
    Q9HCG1
    UniProtKB/TrEMBL
    A0A024R4Q2
    Related
    ENSP00000507845.1, ENST00000683776.1
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:367810
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:623643
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:257279
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:691715
    zf-H2C2_2; Zinc-finger double domain
  8. NM_001322132.2NP_001309061.1  zinc finger protein 160 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 1-7 and 9-12, encodes isoform (a).
    Source sequence(s)
    AC010328
    Consensus CDS
    CCDS12859.1
    UniProtKB/Swiss-Prot
    Q9HCG1
    UniProtKB/TrEMBL
    A0A024R4Q2
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:367810
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:623643
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:257279
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:691715
    zf-H2C2_2; Zinc-finger double domain
  9. NM_001322133.2NP_001309062.1  zinc finger protein 160 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 1-8 and 10-12, encodes isoform (a).
    Source sequence(s)
    AC010328
    Consensus CDS
    CCDS12859.1
    UniProtKB/Swiss-Prot
    Q9HCG1
    UniProtKB/TrEMBL
    A0A024R4Q2
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:367810
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:623643
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:257279
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:691715
    zf-H2C2_2; Zinc-finger double domain
  10. NM_001322134.2NP_001309063.1  zinc finger protein 160 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1-9 and 11-12, encodes isoform (a).
    Source sequence(s)
    AC010328
    Consensus CDS
    CCDS12859.1
    UniProtKB/Swiss-Prot
    Q9HCG1
    UniProtKB/TrEMBL
    A0A024R4Q2
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:367810
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:623643
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:257279
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:691715
    zf-H2C2_2; Zinc-finger double domain
  11. NM_001322135.2NP_001309064.1  zinc finger protein 160 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 1-10 and 12, encodes isoform (a).
    Source sequence(s)
    AC010328
    Consensus CDS
    CCDS12859.1
    UniProtKB/Swiss-Prot
    Q9HCG1
    UniProtKB/TrEMBL
    A0A024R4Q2
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:367810
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:623643
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:257279
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:691715
    zf-H2C2_2; Zinc-finger double domain
  12. NM_001322136.1NP_001309065.1  zinc finger protein 160 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 1-11, encodes isoform (a).
    Source sequence(s)
    AC010328
    Consensus CDS
    CCDS12859.1
    UniProtKB/Swiss-Prot
    Q9HCG1
    UniProtKB/TrEMBL
    A0A024R4Q2
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:367810
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:623643
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:257279
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:691715
    zf-H2C2_2; Zinc-finger double domain
  13. NM_001322137.2NP_001309066.1  zinc finger protein 160 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 14-15, encodes isoform (b).
    Source sequence(s)
    AC010328
    Consensus CDS
    CCDS82391.1
    UniProtKB/TrEMBL
    M0QZI7
    Conserved Domains (5) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:331774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:587607
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:221243
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:655679
    zf-H2C2_2; Zinc-finger double domain
  14. NM_001322138.2NP_001309067.1  zinc finger protein 160 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 13 and 15, encodes isoform (b).
    Source sequence(s)
    AC010328
    Consensus CDS
    CCDS82391.1
    UniProtKB/TrEMBL
    M0QZI7
    Related
    ENSP00000470573.1, ENST00000601421.5
    Conserved Domains (5) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:331774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:587607
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:221243
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:655679
    zf-H2C2_2; Zinc-finger double domain
  15. NM_001322139.2NP_001309068.1  zinc finger protein 160 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 13-14, encodes isoform (b).
    Source sequence(s)
    AC010328
    Consensus CDS
    CCDS82391.1
    UniProtKB/TrEMBL
    M0QZI7
    Conserved Domains (5) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:331774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:587607
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:221243
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:655679
    zf-H2C2_2; Zinc-finger double domain
  16. NM_033288.4NP_150630.2  zinc finger protein 160 isoform a

    See identical proteins and their annotated locations for NP_150630.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variants 2-12, encodes isoform (a).
    Source sequence(s)
    AC010328, BC094880, DB078640
    Consensus CDS
    CCDS12859.1
    UniProtKB/Swiss-Prot
    Q9HCG1
    UniProtKB/TrEMBL
    A0A024R4Q2
    Related
    ENSP00000409597.1, ENST00000418871.5
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:367810
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:623643
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:257279
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:691715
    zf-H2C2_2; Zinc-finger double domain
  17. NM_198893.3NP_942596.1  zinc finger protein 160 isoform a

    See identical proteins and their annotated locations for NP_942596.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3-12, encodes isoform (a).
    Source sequence(s)
    AC010328, BC094880, DB078640
    Consensus CDS
    CCDS12859.1
    UniProtKB/Swiss-Prot
    Q9HCG1
    UniProtKB/TrEMBL
    A0A024R4Q2
    Related
    ENSP00000470961.1, ENST00000599056.5
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:367810
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:623643
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:257279
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:691715
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    53066614..53103422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027448.2XP_016882937.1  zinc finger protein 160 isoform X2

    UniProtKB/Swiss-Prot
    Q9HCG1
    Conserved Domains (2) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    pfam01352
    Location:847
    KRAB; KRAB box
  2. XM_017027447.2XP_016882936.1  zinc finger protein 160 isoform X1

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