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THAP3 THAP domain containing 3 [ Homo sapiens (human) ]

Gene ID: 90326, updated on 5-Jan-2022

Summary

Official Symbol
THAP3provided by HGNC
Official Full Name
THAP domain containing 3provided by HGNC
Primary source
HGNC:HGNC:20855
See related
Ensembl:ENSG00000041988 MIM:612532
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Involved in positive regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in kidney (RPKM 8.5), spleen (RPKM 6.2) and 25 other tissues See more
Orthologs
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Genomic context

See THAP3 in Genome Data Viewer
Location:
1p36.31
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (6624616..6635595)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6684928..6695646)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984913 Neighboring gene PHD finger protein 13 Neighboring gene DnaJ heat shock protein family (Hsp40) member C11 Neighboring gene Sharpr-MPRA regulatory region 8512 Neighboring gene long intergenic non-protein coding RNA 1672

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of THAP domain containing, apoptosis associated protein 3 (THAP3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33488

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
THAP domain-containing protein 3
Names
THAP domain containing, apoptosis associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195752.2NP_001182681.1  THAP domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001182681.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and it encodes isoform 1.
    Source sequence(s)
    AL031447
    Consensus CDS
    CCDS55573.1
    UniProtKB/Swiss-Prot
    Q8WTV1
    Related
    ENSP00000311537.6, ENST00000307896.10
    Conserved Domains (1) summary
    pfam05485
    Location:482
    THAP; THAP domain
  2. NM_001195753.2NP_001182682.1  THAP domain-containing protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001182682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a different 5' exon and uses a different splice site, compared to variant 1. The resulting protein (isoform 3) is longer by 1 amino acid when it is compared to isoform 1.
    Source sequence(s)
    BC092427, BM931707, BU624154
    Consensus CDS
    CCDS55572.1
    UniProtKB/Swiss-Prot
    Q8WTV1
    Related
    ENSP00000054650.4, ENST00000054650.9
    Conserved Domains (1) summary
    pfam05485
    Location:482
    THAP; THAP domain
  3. NM_001394496.1NP_001381425.1  THAP domain-containing protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL031447
    Conserved Domains (1) summary
    smart00980
    Location:482
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
  4. NM_001394497.1NP_001381426.1  THAP domain-containing protein 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL031447
    Conserved Domains (1) summary
    pfam05485
    Location:682
    THAP; THAP domain
  5. NM_001394498.1NP_001381427.1  THAP domain-containing protein 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL031447
    Conserved Domains (1) summary
    smart00980
    Location:482
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
  6. NM_001394499.1NP_001381428.1  THAP domain-containing protein 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL031447
    Conserved Domains (1) summary
    pfam05485
    Location:682
    THAP; THAP domain
  7. NM_001394500.1NP_001381429.1  THAP domain-containing protein 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL031447
    Conserved Domains (1) summary
    pfam05485
    Location:682
    THAP; THAP domain
  8. NM_138350.4NP_612359.2  THAP domain-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_612359.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site and contains a different terminal exon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AL031447
    Consensus CDS
    CCDS86.1
    UniProtKB/Swiss-Prot
    Q8WTV1
    Related
    ENSP00000366854.3, ENST00000377627.7
    Conserved Domains (1) summary
    pfam05485
    Location:482
    THAP; THAP domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    6624616..6635595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450686.1XP_024306454.1  THAP domain-containing protein 3 isoform X4

    Conserved Domains (1) summary
    pfam05485
    Location:682
    THAP; THAP domain
  2. XM_011542400.2XP_011540702.1  THAP domain-containing protein 3 isoform X2

    Conserved Domains (1) summary
    PHA03247
    Location:4123
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. XR_002957988.1 RNA Sequence

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