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ZNF616 zinc finger protein 616 [ Homo sapiens (human) ]

Gene ID: 90317, updated on 7-Aug-2022

Summary

Official Symbol
ZNF616provided by HGNC
Official Full Name
zinc finger protein 616provided by HGNC
Primary source
HGNC:HGNC:28062
See related
Ensembl:ENSG00000204611 AllianceGenome:HGNC:28062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 3.2), ovary (RPKM 2.2) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF616 in Genome Data Viewer
Location:
19q13.41
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52113091..52139938, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55200303..55227149, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52616344..52643191, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 432 Neighboring gene zinc finger protein 160 pseudogene Neighboring gene zinc finger protein 841 Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein L37 pseudogene 23 Neighboring gene zinc finger protein 836

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC45556, MGC149778

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178523.5NP_848618.2  zinc finger protein 616

    See identical proteins and their annotated locations for NP_848618.2

    Status: VALIDATED

    Source sequence(s)
    AC011468, AK092266, BC032805, CD048470
    Consensus CDS
    CCDS33090.1
    UniProtKB/Swiss-Prot
    Q08AN1, Q658V7
    Related
    ENSP00000471000.1, ENST00000600228.6
    Conserved Domains (5) summary
    smart00349
    Location:761
    KRAB; krueppel associated box
    COG5048
    Location:266707
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:271291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:746
    KRAB; KRAB box
    pfam13465
    Location:620644
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_135823.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011468, AK092266, BC032805, BC125100, DA735752

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    52113091..52139938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439613.1XP_047295569.1  zinc finger protein 616 isoform X1

    UniProtKB/Swiss-Prot
    Q658V7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55200303..55227149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)