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EFCAB12 EF-hand calcium binding domain 12 [ Homo sapiens (human) ]

Gene ID: 90288, updated on 17-Jun-2024

Summary

Official Symbol
EFCAB12provided by HGNC
Official Full Name
EF-hand calcium binding domain 12provided by HGNC
Primary source
HGNC:HGNC:28061
See related
Ensembl:ENSG00000172771 AllianceGenome:HGNC:28061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C3orf25
Summary
Predicted to enable calcium ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 1.8), prostate (RPKM 1.5) and 14 other tissues See more
Orthologs
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Genomic context

See EFCAB12 in Genome Data Viewer
Location:
3q21.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (129401321..129428636, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (132146154..132175347, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (129120164..129147479, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129066385-129066884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129072356-129072856 Neighboring gene MARK2 pseudogene 19 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129076650-129077534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129084869-129085400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129085401-129085930 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:129107257-129108456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129113559-129114255 Neighboring gene ribosomal protein L32 pseudogene 3 Neighboring gene small nucleolar RNA, H/ACA box 7B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129129626-129130126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129137243-129137742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20517 Neighboring gene Sharpr-MPRA regulatory region 8693 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:129168229-129168945 Neighboring gene methyl-CpG binding domain 4, DNA glycosylase Neighboring gene intraflagellar transport 122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:129200162-129201039 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:129208521-129208729 Neighboring gene Sharpr-MPRA regulatory region 10640 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:129213542-129214741

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of chromosome 3 open reading frame 25 (C3orf25) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
EF-hand calcium-binding domain-containing protein 12
Names
EF-hand domain-containing protein C3orf25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207307.3NP_997190.1  EF-hand calcium-binding domain-containing protein 12

    See identical proteins and their annotated locations for NP_997190.1

    Status: VALIDATED

    Source sequence(s)
    AK127968, BC066975
    Consensus CDS
    CCDS54638.1
    UniProtKB/Swiss-Prot
    Q69YX4, Q6NXP0
    UniProtKB/TrEMBL
    B3KXU6
    Related
    ENSP00000420854.1, ENST00000505956.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    129401321..129428636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    132146154..132175347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348318.1XP_054204293.1  EF-hand calcium-binding domain-containing protein 12 isoform X2

    UniProtKB/TrEMBL
    B3KXU6
  2. XM_054348319.1XP_054204294.1  EF-hand calcium-binding domain-containing protein 12 isoform X3

    UniProtKB/TrEMBL
    B3KXU6
  3. XM_054348321.1XP_054204296.1  EF-hand calcium-binding domain-containing protein 12 isoform X5

  4. XM_054348320.1XP_054204295.1  EF-hand calcium-binding domain-containing protein 12 isoform X4

  5. XM_054348317.1XP_054204292.1  EF-hand calcium-binding domain-containing protein 12 isoform X1

    UniProtKB/TrEMBL
    B3KXU6
  6. XM_054348323.1XP_054204298.1  EF-hand calcium-binding domain-containing protein 12 isoform X7

  7. XM_054348322.1XP_054204297.1  EF-hand calcium-binding domain-containing protein 12 isoform X6