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EFCAB12 EF-hand calcium binding domain 12 [ Homo sapiens (human) ]

Gene ID: 90288, updated on 23-Nov-2021

Summary

Official Symbol
EFCAB12provided by HGNC
Official Full Name
EF-hand calcium binding domain 12provided by HGNC
Primary source
HGNC:HGNC:28061
See related
Ensembl:ENSG00000172771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C3orf25
Expression
Broad expression in testis (RPKM 1.8), prostate (RPKM 1.5) and 14 other tissues See more
Orthologs
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Genomic context

See EFCAB12 in Genome Data Viewer
Location:
3q21.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (129401321..129428636, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (129120164..129147479, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene microtubule affinity regulating kinase 2 pseudogene Neighboring gene ribosomal protein L32 pseudogene 3 Neighboring gene small nucleolar RNA, H/ACA box 7B Neighboring gene Sharpr-MPRA regulatory region 8693 Neighboring gene methyl-CpG binding domain 4, DNA glycosylase Neighboring gene intraflagellar transport 122

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of chromosome 3 open reading frame 25 (C3orf25) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
EF-hand calcium-binding domain-containing protein 12
Names
EF-hand domain-containing protein C3orf25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207307.3NP_997190.1  EF-hand calcium-binding domain-containing protein 12

    See identical proteins and their annotated locations for NP_997190.1

    Status: VALIDATED

    Source sequence(s)
    AK127968, BC066975
    Consensus CDS
    CCDS54638.1
    UniProtKB/Swiss-Prot
    Q6NXP0
    UniProtKB/TrEMBL
    B3KXU6
    Related
    ENSP00000420854.1, ENST00000505956.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    129401321..129428636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513297.2XP_011511599.1  EF-hand calcium-binding domain-containing protein 12 isoform X4

  2. XM_011513294.2XP_011511596.1  EF-hand calcium-binding domain-containing protein 12 isoform X2

  3. XM_011513295.2XP_011511597.1  EF-hand calcium-binding domain-containing protein 12 isoform X3

  4. XM_011513293.2XP_011511595.1  EF-hand calcium-binding domain-containing protein 12 isoform X1

  5. XM_011513299.2XP_011511601.1  EF-hand calcium-binding domain-containing protein 12 isoform X6

  6. XM_011513298.1XP_011511600.1  EF-hand calcium-binding domain-containing protein 12 isoform X5

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