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CEACAM21 CEA cell adhesion molecule 21 [ Homo sapiens (human) ]

Gene ID: 90273, updated on 1-Jun-2020

Summary

Official Symbol
CEACAM21provided by HGNC
Official Full Name
CEA cell adhesion molecule 21provided by HGNC
Primary source
HGNC:HGNC:28834
See related
Ensembl:ENSG00000007129 MIM:618191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEACAM3; R29124_1
Expression
Broad expression in lymph node (RPKM 2.0), bone marrow (RPKM 1.9) and 15 other tissues See more
Orthologs

Genomic context

See CEACAM21 in Genome Data Viewer
Location:
19q13.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41549236..41586844)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42055886..42093255)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing A3 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1480 Neighboring gene Sharpr-MPRA regulatory region 9744 Neighboring gene RNA, 28S ribosomal pseudogene Neighboring gene uncharacterized LOC105372404 Neighboring gene CEA cell adhesion molecule pseudogene 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.
NHGRI GWA Catalog
DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13540, MGC119874, AC006129.2

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 21
Names
carcinoembryonic antigen related cell adhesion molecule 21

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098506.4NP_001091976.3  carcinoembryonic antigen-related cell adhesion molecule 21 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC243960, AY358084, BC012001, BC106727
    Consensus CDS
    CCDS46086.1
    UniProtKB/Swiss-Prot
    Q3KPI0
    UniProtKB/TrEMBL
    A0A0G2JSC8
    Related
    ENSP00000385739.2, ENST00000401445.4
    Conserved Domains (2) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:142232
    Ig; Immunoglobulin domain
  2. NM_001288773.3NP_001275702.2  carcinoembryonic antigen-related cell adhesion molecule 21 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the 5' UTR and 5' coding region, compared to variant 1, and initiates translation at an alternate start codon. The resulting isoform (3) is shorter and has a different N-terminus, compared to isoform 1.
    Source sequence(s)
    AK023602, AY358084, BC012001, BI913326
    Consensus CDS
    CCDS74373.1
    UniProtKB/Swiss-Prot
    Q3KPI0
    UniProtKB/TrEMBL
    A0A0B4J1W4
    Related
    ENSP00000384380.1, ENST00000407170.6
    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  3. NM_001290113.2NP_001277042.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses two alternate splice sites in the 5' region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a different N-terminus, compared to isoform 1.
    Source sequence(s)
    AC243960, AY358084, BC012001
    UniProtKB/Swiss-Prot
    Q3KPI0
    Conserved Domains (2) summary
    smart00410
    Location:24104
    IG_like; Immunoglobulin like
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  4. NM_033543.6NP_291021.4  carcinoembryonic antigen-related cell adhesion molecule 21 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC243960, AY358084, BC012001
    Consensus CDS
    CCDS46087.1
    UniProtKB/Swiss-Prot
    Q3KPI0
    Related
    ENSP00000187608.9, ENST00000187608.13
    Conserved Domains (3) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:152232
    IG_like; Immunoglobulin like
    cl11960
    Location:142232
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    41549236..41586844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451760.1XP_024307528.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  2. XM_011527450.1XP_011525752.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    UniProtKB/TrEMBL
    A0A0B4J1W4
    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  3. XM_017027433.1XP_016882922.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    UniProtKB/TrEMBL
    A0A0B4J1W4
    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  4. XM_011527452.1XP_011525754.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    UniProtKB/TrEMBL
    A0A0B4J1W4
    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  5. XM_024451757.1XP_024307525.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  6. XM_024451767.1XP_024307535.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  7. XM_024451761.1XP_024307529.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  8. XM_024451763.1XP_024307531.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  9. XM_024451762.1XP_024307530.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  10. XM_024451765.1XP_024307533.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  11. XM_024451755.1XP_024307523.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  12. XM_024451764.1XP_024307532.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  13. XM_017027434.2XP_016882923.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X6

    Conserved Domains (2) summary
    smart00410
    Location:24104
    IG_like; Immunoglobulin like
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  14. XM_017027435.2XP_016882924.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X6

    Conserved Domains (2) summary
    smart00410
    Location:24104
    IG_like; Immunoglobulin like
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  15. XM_017027436.1XP_016882925.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X6

    Conserved Domains (2) summary
    smart00410
    Location:24104
    IG_like; Immunoglobulin like
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  16. XM_024451759.1XP_024307527.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  17. XM_024451766.1XP_024307534.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  18. XM_024451756.1XP_024307524.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  19. XM_024451758.1XP_024307526.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  20. XM_024451769.1XP_024307537.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  21. XM_024451768.1XP_024307536.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    Conserved Domains (1) summary
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  22. XM_017027437.2XP_016882926.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X6

    Conserved Domains (2) summary
    smart00410
    Location:24104
    IG_like; Immunoglobulin like
    cl11960
    Location:14104
    Ig; Immunoglobulin domain
  23. XM_017027430.1XP_016882919.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X1

  24. XM_017027431.1XP_016882920.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X1

  25. XM_017027432.2XP_016882921.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X2

  26. XM_005278396.4XP_005278453.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X3

    UniProtKB/Swiss-Prot
    Q3KPI0
    UniProtKB/TrEMBL
    A0A0G2JSC8
    Conserved Domains (2) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:142232
    Ig; Immunoglobulin domain
  27. XM_005278397.4XP_005278454.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X4

    UniProtKB/Swiss-Prot
    Q3KPI0
    Conserved Domains (3) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:152232
    IG_like; Immunoglobulin like
    cl11960
    Location:142232
    Ig; Immunoglobulin domain

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187620.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    95157..132483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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