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UNC5A unc-5 netrin receptor A [ Homo sapiens (human) ]

Gene ID: 90249, updated on 23-Nov-2021

Summary

Official Symbol
UNC5Aprovided by HGNC
Official Full Name
unc-5 netrin receptor Aprovided by HGNC
Primary source
HGNC:HGNC:12567
See related
Ensembl:ENSG00000113763 MIM:607869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNC5H1
Summary
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]
Expression
Biased expression in brain (RPKM 7.1) and adrenal (RPKM 2.6) See more
Orthologs
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Genomic context

See UNC5A in Genome Data Viewer
Location:
5q35.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (176810559..176880898)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176237560..176307899)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs2007 Neighboring gene tetraspanin 17 Neighboring gene long intergenic non-protein coding RNA 1574 Neighboring gene hexokinase 3 Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene zinc finger protein 346

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16449, KIAA1976

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables netrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in netrin-activated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intrinsic component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal cell body membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
netrin receptor UNC5A
Names
netrin receptor Unc5h1
protein unc-5 homolog 1
protein unc-5 homolog A
unc-5 homolog 1
unc-5 homolog A
unc5 (C.elegans homolog) a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133369.3NP_588610.2  netrin receptor UNC5A precursor

    See identical proteins and their annotated locations for NP_588610.2

    Status: VALIDATED

    Source sequence(s)
    AC091902, BC009333, BC033727, BI818609, BM712478
    Consensus CDS
    CCDS34299.1
    UniProtKB/Swiss-Prot
    Q6ZN44
    Related
    ENSP00000332737.4, ENST00000329542.9
    Conserved Domains (5) summary
    smart00218
    Location:439542
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:245293
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:151239
    I-set; Immunoglobulin I-set domain
    cd08800
    Location:755838
    Death_UNC5A; Death domain found in Uncoordinated-5A
    cl11960
    Location:153239
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    176810559..176880898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714928.1XP_006714991.1  netrin receptor UNC5A isoform X3

    Related
    ENSP00000421795.2, ENST00000509580.2
    Conserved Domains (5) summary
    smart00218
    Location:495598
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:245296
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:151239
    I-set; Immunoglobulin I-set domain
    cd08800
    Location:811894
    Death_UNC5A; Death domain found in Uncoordinated-5A
    cl11960
    Location:153239
    Ig; Immunoglobulin domain
  2. XM_011534686.1XP_011532988.1  netrin receptor UNC5A isoform X1

    Conserved Domains (4) summary
    smart00218
    Location:495598
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:245296
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:151239
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:153239
    Ig; Immunoglobulin domain
  3. XM_006714927.1XP_006714990.1  netrin receptor UNC5A isoform X2

    Conserved Domains (4) summary
    smart00218
    Location:439542
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:245293
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:151239
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:153239
    Ig; Immunoglobulin domain
  4. XM_011534687.2XP_011532989.1  netrin receptor UNC5A isoform X4

    Conserved Domains (4) summary
    smart00209
    Location:245296
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:151239
    I-set; Immunoglobulin I-set domain
    cl02517
    Location:495515
    ZU5; ZU5 domain
    cl11960
    Location:153239
    Ig; Immunoglobulin domain
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