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ZNF551 zinc finger protein 551 [ Homo sapiens (human) ]

Gene ID: 90233, updated on 23-Nov-2021

Summary

Official Symbol
ZNF551provided by HGNC
Official Full Name
zinc finger protein 551provided by HGNC
Primary source
HGNC:HGNC:25108
See related
Ensembl:ENSG00000204519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in bone marrow (RPKM 2.9), testis (RPKM 2.8) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF551 in Genome Data Viewer
Location:
19q13.43
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (57681977..57690648)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58193345..58202016)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 211 Neighboring gene zinc finger and SCAN domain containing 4 Neighboring gene tumor protein p63 regulated 1 like pseudogene 1 Neighboring gene zinc finger protein 154 Neighboring gene zinc finger protein 671

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ZNF776

Homology

Clone Names

  • MGC52307, DKFZp686H1038

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 551
Names
KOX 23 protein (56 AA)
zinc finger protein KOX23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270938.2NP_001257867.1  zinc finger protein 551 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at the 3' end of the first exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC004017, AK307670, BC005868
    UniProtKB/Swiss-Prot
    Q7Z340
    Related
    ENSP00000472674.1, ENST00000601064.1
    Conserved Domains (5) summary
    smart00349
    Location:143
    KRAB; krueppel associated box
    COG5048
    Location:251596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:561581
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:140
    KRAB; KRAB box
    pfam13465
    Location:601626
    zf-H2C2_2; Zinc-finger double domain
  2. NM_138347.5NP_612356.2  zinc finger protein 551 isoform 1

    See identical proteins and their annotated locations for NP_612356.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC004017, AK307670, BC005868
    Consensus CDS
    CCDS12959.2
    UniProtKB/Swiss-Prot
    Q7Z340
    Related
    ENSP00000282296.5, ENST00000282296.10
    Conserved Domains (5) summary
    smart00349
    Location:2971
    KRAB; krueppel associated box
    COG5048
    Location:279624
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:589609
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2968
    KRAB; KRAB box
    pfam13465
    Location:629654
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_073102.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon compared to variant 1. The resulting transcript has an overlapping upstream ORF with a strong Kozak signal, making this a candidate for nonsense-mediated mRNA decay (NMD). Therefore, it is unlikely that this variant encodes a protein.
    Source sequence(s)
    AC004017, AK300465, AK307670, BC005868

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    57681977..57690648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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