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CLIC3 chloride intracellular channel 3 [ Homo sapiens (human) ]

Gene ID: 9022, updated on 13-Mar-2020

Summary

Official Symbol
CLIC3provided by HGNC
Official Full Name
chloride intracellular channel 3provided by HGNC
Primary source
HGNC:HGNC:2064
See related
Ensembl:ENSG00000169583 MIM:606533
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 23.8), thyroid (RPKM 21.4) and 5 other tissues See more
Orthologs

Genomic context

See CLIC3 in Genome Data Viewer
Location:
9q34.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (136994608..136997929, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139889060..139892200, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene lipocalin like 1 Neighboring gene PAXX non-homologous end joining factor Neighboring gene ATP binding cassette subfamily A member 2 Neighboring gene chromosome 9 open reading frame 139 Neighboring gene fucosyltransferase 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
chloride transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chloride intracellular channel protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004669.3NP_004660.2  chloride intracellular channel protein 3

    See identical proteins and their annotated locations for NP_004660.2

    Status: REVIEWED

    Source sequence(s)
    AF102166, AI741256, BF439361, BM043659
    Consensus CDS
    CCDS7021.1
    UniProtKB/Swiss-Prot
    O95833
    Related
    ENSP00000419378.1, ENST00000494426.2
    Conserved Domains (1) summary
    cl25455
    Location:5229
    PLN02817; glutathione dehydrogenase (ascorbate)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    136994608..136997929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015281.1XP_016870770.1  chloride intracellular channel protein 3 isoform X1

  2. XM_017015282.1XP_016870771.1  chloride intracellular channel protein 3 isoform X2

    UniProtKB/Swiss-Prot
    O95833
    UniProtKB/TrEMBL
    Q6FGP1
    Conserved Domains (2) summary
    cd10299
    Location:69201
    GST_C_CLIC3; C-terminal, alpha helical domain of Chloride Intracellular Channel 3
    cl00388
    Location:162
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
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