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MAP3K14 mitogen-activated protein kinase kinase kinase 14 [ Homo sapiens (human) ]

Gene ID: 9020, updated on 9-Feb-2020

Summary

Official Symbol
MAP3K14provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 14provided by HGNC
Primary source
HGNC:HGNC:6853
See related
Ensembl:ENSG00000006062 MIM:604655
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HS; NIK; HSNIK; FTDCR1B
Summary
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 11.1), spleen (RPKM 8.5) and 25 other tissues See more
Orthologs

Genomic context

See MAP3K14 in Genome Data Viewer
Location:
17q21.31
Exon count:
17
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (45263119..45317048, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43340488..43394414, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene formin like 1 Neighboring gene uncharacterized LOC107985040 Neighboring gene MAP3K14 antisense RNA 1 Neighboring gene spermatogenesis associated 32 Neighboring gene RNA, 5S ribosomal pseudogene 443 Neighboring gene uncharacterized LOC105371796

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mitogen-activated protein kinase kinase kinase 14 (MAP3K14) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat enhances the capacity of NF-kappaB-inducing kinase (NIK) to accelerate degradation of IkappaB PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
NF-kappaB-inducing kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
kinase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
NIK/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
activation of MAPKK activity IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 14
Names
NF-kappa-beta-inducing kinase
serine/threonine-protein kinase NIK
NP_003945.2
XP_011523743.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033823.1 RefSeqGene

    Range
    5029..58930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1222

mRNA and Protein(s)

  1. NM_003954.5NP_003945.2  mitogen-activated protein kinase kinase kinase 14

    See identical proteins and their annotated locations for NP_003945.2

    Status: REVIEWED

    Source sequence(s)
    AK290203, CR749592, HY287427, Y10256
    Consensus CDS
    CCDS74079.1
    UniProtKB/Swiss-Prot
    Q99558
    UniProtKB/TrEMBL
    Q68D39
    Related
    ENSP00000478552.1, ENST00000344686.8
    Conserved Domains (2) summary
    smart00220
    Location:406665
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13991
    Location:393660
    STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    45263119..45317048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525441.2XP_011523743.1  mitogen-activated protein kinase kinase kinase 14 isoform X1

    See identical proteins and their annotated locations for XP_011523743.1

    UniProtKB/Swiss-Prot
    Q99558
    Conserved Domains (2) summary
    smart00220
    Location:406665
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13991
    Location:393660
    STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

RNA

  1. XR_934591.1 RNA Sequence

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