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PHLDB2 pleckstrin homology like domain family B member 2 [ Homo sapiens (human) ]

Gene ID: 90102, updated on 13-Mar-2020

Summary

Official Symbol
PHLDB2provided by HGNC
Official Full Name
pleckstrin homology like domain family B member 2provided by HGNC
Primary source
HGNC:HGNC:29573
See related
Ensembl:ENSG00000144824 MIM:610298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LL5b; LL5beta
Expression
Ubiquitous expression in placenta (RPKM 18.1), kidney (RPKM 15.7) and 24 other tissues See more
Orthologs

Genomic context

See PHLDB2 in Genome Data Viewer
Location:
3q13.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (111732496..111976517)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (111451327..111695364)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CD96 molecule Neighboring gene NT5C3A pseudogene 2 Neighboring gene PLCXD2 antisense RNA 1 Neighboring gene phosphatidylinositol specific phospholipase C X domain containing 2 Neighboring gene uncharacterized LOC107984087 Neighboring gene uncharacterized LOC105374040 Neighboring gene abhydrolase domain containing 10, depalmitoylase Neighboring gene transgelin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PLCXD2

Homology

Clone Names

  • FLJ21791, DKFZp434G227, DKFZp313O2433, DKFZp686J05113

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
basal cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
basal cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
pleckstrin homology-like domain family B member 2
Names
LL5 beta
protein LL5-beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134437.2NP_001127909.1  pleckstrin homology-like domain family B member 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has a longer N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AC060225, AF506820, AW264132, CA310697, CR749654, DA447763
    Consensus CDS
    CCDS46885.1
    UniProtKB/Swiss-Prot
    Q86SQ0
    Related
    ENSP00000377500.3, ENST00000393923.7
    Conserved Domains (4) summary
    cd14673
    Location:11261230
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam00169
    Location:11291225
    PH; PH domain
    cl02488
    Location:610774
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl19107
    Location:10201089
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
  2. NM_001134438.2NP_001127910.1  pleckstrin homology-like domain family B member 2 isoform a

    See identical proteins and their annotated locations for NP_001127910.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC060225, AK315050, AW264132, DA438817
    Consensus CDS
    CCDS46886.1
    UniProtKB/Swiss-Prot
    Q86SQ0
    Related
    ENSP00000405405.2, ENST00000431670.7
    Conserved Domains (5) summary
    cd14673
    Location:11421246
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam00169
    Location:11451241
    PH; PH domain
    pfam06008
    Location:524779
    Laminin_I; Laminin Domain I
    cl02488
    Location:583790
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl19107
    Location:10361095
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
  3. NM_001134439.2NP_001127911.1  pleckstrin homology-like domain family B member 2 isoform a

    See identical proteins and their annotated locations for NP_001127911.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AB209903, AC060225, AW264132, DA272187
    Consensus CDS
    CCDS46886.1
    UniProtKB/Swiss-Prot
    Q86SQ0
    Related
    ENSP00000377502.3, ENST00000393925.7
    Conserved Domains (5) summary
    cd14673
    Location:11421246
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam00169
    Location:11451241
    PH; PH domain
    pfam06008
    Location:524779
    Laminin_I; Laminin Domain I
    cl02488
    Location:583790
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl19107
    Location:10361095
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
  4. NM_145753.2NP_665696.1  pleckstrin homology-like domain family B member 2 isoform c

    See identical proteins and their annotated locations for NP_665696.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC060225, AK315050, AW264132, BC069194, DA438817
    Consensus CDS
    CCDS2962.1
    UniProtKB/Swiss-Prot
    Q86SQ0
    Related
    ENSP00000405292.1, ENST00000412622.5
    Conserved Domains (4) summary
    cd14673
    Location:10991203
    PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    pfam00169
    Location:11021198
    PH; PH domain
    cl02488
    Location:583747
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl19107
    Location:9931062
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    111732496..111976517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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