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LACRT lacritin [ Homo sapiens (human) ]

Gene ID: 90070, updated on 11-Jun-2021

Summary

Official Symbol
LACRTprovided by HGNC
Official Full Name
lacritinprovided by HGNC
Primary source
HGNC:HGNC:16430
See related
Ensembl:ENSG00000135413 MIM:607360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward salivary gland (RPKM 2.0) See more
Orthologs
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Genomic context

See LACRT in Genome Data Viewer
Location:
12q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (54630811..54634895, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (55024595..55028679, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 1A Neighboring gene glycosylation dependent cell adhesion molecule 1 (pseudogene) Neighboring gene dermcidin Neighboring gene voltage dependent anion channel 1 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71934

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables collagen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables fibronectin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables laminin-1 binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in calcineurin-NFAT signaling cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epithelial structure maintenance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of calcineurin-NFAT signaling cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation involved in wound healing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tear secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tear secretion NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space HDA PubMed 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
extracellular glycoprotein lacritin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033277.2NP_150593.1  extracellular glycoprotein lacritin precursor

    See identical proteins and their annotated locations for NP_150593.1

    Status: REVIEWED

    Source sequence(s)
    AC079310
    Consensus CDS
    CCDS8883.1
    UniProtKB/Swiss-Prot
    Q9GZZ8
    Related
    ENSP00000257867.4, ENST00000257867.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    54630811..54634895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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