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fctA FCT-2 pilus major pilin FctA [ Streptococcus pyogenes M1 GAS ]

Gene ID: 900460, discontinued on 22-Mar-2020
  • This record was discontinued.
Gene symbol
fctA
Gene description
FCT-2 pilus major pilin FctA
Locus tag
SPY_RS00725
Gene type
protein coding
Organism
Streptococcus pyogenes M1 GAS (strain: SF370, serotype: M1)
Lineage
Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus
Old locus tag
SPy0128; SPy_0128
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Genomic Sequence:
NC_002737.2

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. an intact Spy0128 is inextensible at any force, peptide-modified Spy0128 pilins readily unfold at very low forces, marking the abrogation of the intramolecular isopeptide bond as well as the absence of a stable pilin fold.
    Title: Molecular strategy for blocking isopeptide bond formation in nascent pilin proteins.
  2. The crystal structure of the major pilin of S. pyogenes, Spy0128, revealed that each domain of the two domain protein contained an intramolecular isopeptide bond cross-link joining a Lys side chain to an Asn side chain.
    Title: Intramolecular isopeptide bonds give thermodynamic and proteolytic stability to the major pilin protein of Streptococcus pyogenes.
  3. crystal structure of the major pilin subunit at 2.2 Angstrom resolution was determined; each subunit contains two lysine-asparagine isopeptide bonds generated by an intramolecular reaction
    Title: Stabilizing isopeptide bonds revealed in gram-positive bacterial pilus structure.
Submit: New GeneRIF Correction
Preferred Names
FCT-2 pilus major pilin FctA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002737.2 Reference assembly

    Range
    119649..120671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_010921811.1 FCT-2 pilus major pilin FctA [Streptococcus pyogenes]

    See identical proteins and their annotated locations for WP_010921811.1

Nucleotide Protein
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Gene LinkOut

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