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MIDN midnolin [ Homo sapiens (human) ]

Gene ID: 90007, updated on 24-Nov-2020

Summary

Official Symbol
MIDNprovided by HGNC
Official Full Name
midnolinprovided by HGNC
Primary source
HGNC:HGNC:16298
See related
Ensembl:ENSG00000167470 MIM:606700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in bone marrow (RPKM 27.5), gall bladder (RPKM 18.8) and 25 other tissues See more
Orthologs

Genomic context

See MIDN in Genome Data Viewer
Location:
19p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (1248552..1259143)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1248552..1259142)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATP synthase F1 subunit delta Neighboring gene uncharacterized LOC102723811 Neighboring gene uncharacterized LOC107985303 Neighboring gene uncharacterized LOC105372236 Neighboring gene CIRBP antisense RNA 1 Neighboring gene cold inducible RNA binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp547M072

Gene Ontology Provided by GOA

Function Evidence Code Pubs
kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
negative regulation of glucokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
midnolin
Names
midbrain nucleolar protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001388306.1NP_001375235.1  midnolin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004221
  2. NM_001388307.1NP_001375236.1  midnolin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC004221
  3. NM_001388474.1NP_001375403.1  midnolin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC004221
  4. NM_177401.5NP_796375.3  midnolin isoform 2

    See identical proteins and their annotated locations for NP_796375.3

    Status: VALIDATED

    Source sequence(s)
    AA421908, AL512725, BC015089, BC060848, BM966744
    Consensus CDS
    CCDS32864.1
    UniProtKB/Swiss-Prot
    Q504T8
    Related
    ENSP00000300952.2, ENST00000300952.6
    Conserved Domains (1) summary
    cd01804
    Location:30107
    midnolin_N; Ubiquitin-like domain of midnolin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    1248552..1259143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451753.1XP_024307521.1  midnolin isoform X1

    Conserved Domains (1) summary
    cd01804
    Location:30107
    midnolin_N; Ubiquitin-like domain of midnolin
  2. XM_005259672.3XP_005259729.1  midnolin isoform X4

    Conserved Domains (2) summary
    cd01804
    Location:30107
    midnolin_N; Ubiquitin-like domain of midnolin
    smart00213
    Location:3199
    UBQ; Ubiquitin homologues
  3. XM_024451754.1XP_024307522.1  midnolin isoform X2

    Conserved Domains (1) summary
    cd01804
    Location:30107
    midnolin_N; Ubiquitin-like domain of midnolin
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