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CCNG1 cyclin G1 [ Homo sapiens (human) ]

Gene ID: 900, updated on 25-Nov-2021

Summary

Official Symbol
CCNG1provided by HGNC
Official Full Name
cyclin G1provided by HGNC
Primary source
HGNC:HGNC:1592
See related
Ensembl:ENSG00000113328 MIM:601578
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCNG
Summary
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 74.2), small intestine (RPKM 61.6) and 25 other tissues See more
Orthologs
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Genomic context

See CCNG1 in Genome Data Viewer
Location:
5q34
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (163437571..163448199)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (162864577..162875205)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377699 Neighboring gene mitochondrial ribosomal protein L57 pseudogene 6 Neighboring gene uncharacterized LOC105377700 Neighboring gene NudC domain containing 2 Neighboring gene HMMR antisense RNA 1 Neighboring gene hyaluronan mediated motility receptor Neighboring gene methionine adenosyltransferase 2B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic G2 DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to organonitrogen compound IEA
Inferred from Electronic Annotation
more info
 
involved_in syncytium formation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364015.1NP_001350944.1  cyclin-G1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Conserved Domains (1) summary
    cd20583
    Location:51148
    CYCLIN_CCNG1; cyclin box found in cyclin-G1 (CCNG1) and similar proteins
  2. NM_001364018.1NP_001350947.1  cyclin-G1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Conserved Domains (1) summary
    pfam00134
    Location:20149
    Cyclin_N; Cyclin, N-terminal domain
  3. NM_001364019.1NP_001350948.1  cyclin-G1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Conserved Domains (1) summary
    pfam00134
    Location:20149
    Cyclin_N; Cyclin, N-terminal domain
  4. NM_001364020.1NP_001350949.1  cyclin-G1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Conserved Domains (1) summary
    pfam00134
    Location:20149
    Cyclin_N; Cyclin, N-terminal domain
  5. NM_001364021.1NP_001350950.1  cyclin-G1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Conserved Domains (1) summary
    cl00050
    Location:3091
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  6. NM_001364022.1NP_001350951.1  cyclin-G1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Related
    ENSP00000424315.1, ENST00000512163.5
  7. NM_001364023.1NP_001350952.1  cyclin-G1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC112205
  8. NM_004060.4NP_004051.1  cyclin-G1 isoform a

    See identical proteins and their annotated locations for NP_004051.1

    Status: REVIEWED

    Source sequence(s)
    BC000196, BX644635
    Consensus CDS
    CCDS4360.1
    UniProtKB/Swiss-Prot
    P51959
    Related
    ENSP00000344635.2, ENST00000340828.7
    Conserved Domains (1) summary
    cd20583
    Location:51148
    CYCLIN_CCNG1; cyclin box found in cyclin-G1 (CCNG1) and similar proteins
  9. NM_199246.2NP_954854.1  cyclin-G1 isoform a

    See identical proteins and their annotated locations for NP_954854.1

    Status: REVIEWED

    Source sequence(s)
    BC000196, BM479568
    Consensus CDS
    CCDS4360.1
    UniProtKB/Swiss-Prot
    P51959
    Related
    ENSP00000377506.1, ENST00000393929.5
    Conserved Domains (1) summary
    cd20583
    Location:51148
    CYCLIN_CCNG1; cyclin box found in cyclin-G1 (CCNG1) and similar proteins

RNA

  1. NR_157051.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205, BX538035
  2. NR_157052.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205
  3. NR_157053.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205
  4. NR_157054.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205
  5. NR_157055.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205
  6. NR_157056.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    163437571..163448199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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