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CCNG1 cyclin G1 [ Homo sapiens (human) ]

Gene ID: 900, updated on 17-Jun-2019

Summary

Official Symbol
CCNG1provided by HGNC
Official Full Name
cyclin G1provided by HGNC
Primary source
HGNC:HGNC:1592
See related
Ensembl:ENSG00000113328 MIM:601578
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCNG
Summary
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 74.2), small intestine (RPKM 61.6) and 25 other tissues See more
Orthologs

Genomic context

See CCNG1 in Genome Data Viewer
Location:
5q34
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (163437571..163448199)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (162864573..162872022)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377699 Neighboring gene mitochondrial ribosomal protein L57 pseudogene 6 Neighboring gene uncharacterized LOC105377700 Neighboring gene NudC domain containing 2 Neighboring gene HMMR antisense RNA 1 Neighboring gene hyaluronan mediated motility receptor Neighboring gene methionine adenosyltransferase 2B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
    Direct p53 effectors, organism-specific biosystem
    Direct p53 effectors
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Degradation, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Degradation, organism-specific biosystemIn unstressed cells, TP53 (p53) has a short half-life as it undergoes rapid ubiquitination and proteasome-mediated degradation. The E3 ubiquitin ligase MDM2, which is a transcriptional target of TP53...
  • Regulation of TP53 Expression and Degradation, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Expression and Degradation, organism-specific biosystemTP53 (p53) tumor suppressor protein is a transcription factor that functions as a homotetramer (Jeffrey et al. 1995). The protein levels of TP53 are low in unstressed cells due to MDM2-mediated ubiqu...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
  • miRNA Regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
    miRNA Regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...
  • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
    p53 pathway, organism-specific biosystem
    p53 pathway
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364015.1NP_001350944.1  cyclin-G1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Conserved Domains (1) summary
    pfam00134
    Location:20149
    Cyclin_N; Cyclin, N-terminal domain
  2. NM_001364018.1NP_001350947.1  cyclin-G1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Conserved Domains (1) summary
    pfam00134
    Location:20149
    Cyclin_N; Cyclin, N-terminal domain
  3. NM_001364019.1NP_001350948.1  cyclin-G1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Conserved Domains (1) summary
    pfam00134
    Location:20149
    Cyclin_N; Cyclin, N-terminal domain
  4. NM_001364020.1NP_001350949.1  cyclin-G1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Conserved Domains (1) summary
    pfam00134
    Location:20149
    Cyclin_N; Cyclin, N-terminal domain
  5. NM_001364021.1NP_001350950.1  cyclin-G1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC112205
    Conserved Domains (1) summary
    cl00050
    Location:3091
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  6. NM_001364022.1NP_001350951.1  cyclin-G1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC112205
  7. NM_001364023.1NP_001350952.1  cyclin-G1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC112205
  8. NM_004060.4NP_004051.1  cyclin-G1 isoform a

    See identical proteins and their annotated locations for NP_004051.1

    Status: REVIEWED

    Source sequence(s)
    BC000196, BX644635
    Consensus CDS
    CCDS4360.1
    UniProtKB/Swiss-Prot
    P51959
    Related
    ENSP00000344635.2, ENST00000340828.7
    Conserved Domains (1) summary
    pfam00134
    Location:20149
    Cyclin_N; Cyclin, N-terminal domain
  9. NM_199246.2NP_954854.1  cyclin-G1 isoform a

    See identical proteins and their annotated locations for NP_954854.1

    Status: REVIEWED

    Source sequence(s)
    BC000196, BM479568
    Consensus CDS
    CCDS4360.1
    UniProtKB/Swiss-Prot
    P51959
    Related
    ENSP00000377506.1, ENST00000393929.5
    Conserved Domains (1) summary
    pfam00134
    Location:20149
    Cyclin_N; Cyclin, N-terminal domain

RNA

  1. NR_157051.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205, BX538035
  2. NR_157052.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205
  3. NR_157053.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205
  4. NR_157054.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205
  5. NR_157055.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205
  6. NR_157056.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC112205

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    163437571..163448199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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