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HP_RS07580 FAD-dependent thymidylate synthase [ Helicobacter pylori 26695 ]

Gene ID: 899757, discontinued on 23-Mar-2020
  • This record was discontinued.
Gene symbol
HP_RS07580
Gene description
FAD-dependent thymidylate synthase
Locus tag
HP_RS07580
Gene type
protein coding
Organism
Helicobacter pylori 26695 (strain: 26695)
Lineage
Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter
Old locus tag
HP1533; HP_1533
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Genomic Sequence:
NC_000915.1

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Report the crystal structure of ThyX from H. pylori strain 26695 in complex with co-factor FAD and substrate dUMP at 2.5 A resolution. It consists of a 1.5 tetramer of ThyX with a total 1248 residues, six FAD and six dUMP molecules in an asymmetric unit.
    Title: Crystal structure of a flavin-dependent thymidylate synthase from Helicobacter pylori strain 26695.
  2. Cloned and purified the ThyX enzyme from H. pylori SS1 strain. Recombinant HpThyX showed maximum activity at pH 8.5, and K(m) values of the two substrates dUMP and CH(2) H(4) folate were determined to be 15.3 +/- 1.25 muM and 0.35 +/- 0.18 mM, respectively.
    Title: Crystal structure and enzymatic characterization of thymidylate synthase X from Helicobacter pylori strain SS1.
  3. Helicobacter pylori ThyX was purified and crystallized in complex with flavin adenine dinucleotide (FAD) and a diffraction data set was collected to 2.5 A resolution.
    Title: Crystallization and preliminary crystallographic studies of a flavin-dependent thymidylate synthase from Helicobacter pylori.
Submit: New GeneRIF Correction
Preferred Names
FAD-dependent thymidylate synthase
WP_000451918.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000915.1 Reference assembly

    Range
    1611791..1612417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_000451918.1 FAD-dependent thymidylate synthase [Helicobacter pylori]

    See identical proteins and their annotated locations for WP_000451918.1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O26061.2