Format

Send to:

Choose Destination

RSPRY1 ring finger and SPRY domain containing 1 [ Homo sapiens (human) ]

Gene ID: 89970, updated on 1-Jun-2020

Summary

Official Symbol
RSPRY1provided by HGNC
Official Full Name
ring finger and SPRY domain containing 1provided by HGNC
Primary source
HGNC:HGNC:29420
See related
Ensembl:ENSG00000159579 MIM:616585
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEMDFA
Summary
This gene encodes a glycoprotein that contains a RING-type zinc finger domain and an SPRY domain of unknown function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Ubiquitous expression in testis (RPKM 11.4), thyroid (RPKM 9.4) and 25 other tissues See more
Orthologs

Genomic context

See RSPRY1 in Genome Data Viewer
Location:
16q13
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (57186137..57240473)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57220026..57274385)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene copine 2 Neighboring gene Sharpr-MPRA regulatory region 3054 Neighboring gene proteasome activator subunit 3 interacting protein 1 Neighboring gene ADP ribosylation factor like GTPase 2 binding protein Neighboring gene plasmolipin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1972

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
proteolysis involved in cellular protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RING finger and SPRY domain-containing protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046342.1 RefSeqGene

    Range
    5046..59186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001305163.2NP_001292092.1  RING finger and SPRY domain-containing protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001292092.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC009090, AL834402, BC013173
    Consensus CDS
    CCDS10775.1
    UniProtKB/Swiss-Prot
    Q96DX4
    UniProtKB/TrEMBL
    A0A024R6U0
    Related
    ENSP00000443176.1, ENST00000537866.5
    Conserved Domains (2) summary
    cd12883
    Location:359479
    SPRY_RING; SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain
    cd16566
    Location:525565
    RING-HC_RSPRY1; RING finger, HC subclass, found in RING finger and SPRY domain-containing protein 1 (RSPRY1) and similar proteins
  2. NM_001305164.2NP_001292093.1  RING finger and SPRY domain-containing protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001292093.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AB075852, AC009090, AL834402, BC013173, DB083249
    Consensus CDS
    CCDS10775.1
    UniProtKB/Swiss-Prot
    Q96DX4
    UniProtKB/TrEMBL
    A0A024R6U0
    Conserved Domains (2) summary
    cd12883
    Location:359479
    SPRY_RING; SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain
    cd16566
    Location:525565
    RING-HC_RSPRY1; RING finger, HC subclass, found in RING finger and SPRY domain-containing protein 1 (RSPRY1) and similar proteins
  3. NM_001305182.1NP_001292111.1  RING finger and SPRY domain-containing protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001292111.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks multiple exons in the coding region and differs in both the 5' and 3' UTRs, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AY358548, BQ576035, DB083249
    UniProtKB/Swiss-Prot
    Q96DX4
    Related
    ENST00000566352.1
  4. NM_133368.3NP_588609.1  RING finger and SPRY domain-containing protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_588609.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC009090, AL834402, BC013173
    Consensus CDS
    CCDS10775.1
    UniProtKB/Swiss-Prot
    Q96DX4
    UniProtKB/TrEMBL
    A0A024R6U0
    Related
    ENSP00000377942.4, ENST00000394420.9
    Conserved Domains (2) summary
    cd12883
    Location:359479
    SPRY_RING; SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain
    cd16566
    Location:525565
    RING-HC_RSPRY1; RING finger, HC subclass, found in RING finger and SPRY domain-containing protein 1 (RSPRY1) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    57186137..57240473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450483.1XP_024306251.1  RING finger and SPRY domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    cd12883
    Location:390510
    SPRY_RING; SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain
    cd16566
    Location:556596
    RING-HC_RSPRY1; RING finger, HC subclass, found in RING finger and SPRY domain-containing protein 1 (RSPRY1) and similar proteins
  2. XM_024450484.1XP_024306252.1  RING finger and SPRY domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    cd12883
    Location:359479
    SPRY_RING; SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain
    cd16566
    Location:525565
    RING-HC_RSPRY1; RING finger, HC subclass, found in RING finger and SPRY domain-containing protein 1 (RSPRY1) and similar proteins
  3. XM_017023844.2XP_016879333.1  RING finger and SPRY domain-containing protein 1 isoform X3

  4. XM_011523428.2XP_011521730.1  RING finger and SPRY domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011521730.1

    Conserved Domains (2) summary
    cd12883
    Location:390510
    SPRY_RING; SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain
    cd16566
    Location:556596
    RING-HC_RSPRY1; RING finger, HC subclass, found in RING finger and SPRY domain-containing protein 1 (RSPRY1) and similar proteins
  5. XM_011523427.2XP_011521729.1  RING finger and SPRY domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011521729.1

    Conserved Domains (2) summary
    cd12883
    Location:390510
    SPRY_RING; SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain
    cd16566
    Location:556596
    RING-HC_RSPRY1; RING finger, HC subclass, found in RING finger and SPRY domain-containing protein 1 (RSPRY1) and similar proteins
  6. XM_005256220.2XP_005256277.1  RING finger and SPRY domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_005256277.1

    UniProtKB/Swiss-Prot
    Q96DX4
    UniProtKB/TrEMBL
    A0A024R6U0
    Conserved Domains (2) summary
    cd12883
    Location:359479
    SPRY_RING; SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain
    cd16566
    Location:525565
    RING-HC_RSPRY1; RING finger, HC subclass, found in RING finger and SPRY domain-containing protein 1 (RSPRY1) and similar proteins
  7. XM_011523430.1XP_011521732.1  RING finger and SPRY domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011521732.1

    Conserved Domains (2) summary
    cd12883
    Location:390510
    SPRY_RING; SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain
    cd16566
    Location:556596
    RING-HC_RSPRY1; RING finger, HC subclass, found in RING finger and SPRY domain-containing protein 1 (RSPRY1) and similar proteins
  8. XM_024450482.1XP_024306250.1  RING finger and SPRY domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    cd12883
    Location:390510
    SPRY_RING; SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain
    cd16566
    Location:556596
    RING-HC_RSPRY1; RING finger, HC subclass, found in RING finger and SPRY domain-containing protein 1 (RSPRY1) and similar proteins
Support Center