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NOL3 nucleolar protein 3 [ Homo sapiens (human) ]

Gene ID: 8996, updated on 10-Oct-2019

Summary

Official Symbol
NOL3provided by HGNC
Official Full Name
nucleolar protein 3provided by HGNC
Primary source
HGNC:HGNC:7869
See related
Ensembl:ENSG00000140939 MIM:605235
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC; FCM; MYP; NOP; NOP30; MYOCL1
Summary
This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in skin (RPKM 15.7), prostate (RPKM 15.6) and 24 other tissues See more
Orthologs

Genomic context

See NOL3 in Genome Data Viewer
Location:
16q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (67170497..67175737)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67204400..67209640)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene TNFRSF1A associated via death domain Neighboring gene F-box and leucine rich repeat protein 8 Neighboring gene heat shock transcription factor 4 Neighboring gene KIAA0895 like Neighboring gene exocyst complex component 3 like 1 Neighboring gene E2F transcription factor 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nucleolar protein 3, apoptosis repressor with CARD domain (NOL3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35304

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
calcium ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
caspase binding IPI
Inferred from Physical Interaction
more info
PubMed 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nucleolar protein 3
Names
muscle-enriched cytoplasmic protein
nucleolar protein 3 (apoptosis repressor with CARD domain)
nucleolar protein of 30 kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029566.1 RefSeqGene

    Range
    8352..10236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001185057.2NP_001171986.1  nucleolar protein 3 isoform Nop30

    See identical proteins and their annotated locations for NP_001171986.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) originates from a different promoter, has a shorter 5' UTR, and uses an alternate splice site in the CDS, compared to variant 1. This transcript and protein were described by Stoss et al. (PMID: 10196175). The resulting protein (Nop30) has the same N-terminus and then is frameshifted resulting in a distinct C-terminus, compared to isoform MYP.
    Source sequence(s)
    AF064599, DA928396
    Consensus CDS
    CCDS58473.1
    UniProtKB/Swiss-Prot
    O60936
    Related
    ENSP00000454598.1, ENST00000568146.1
    Conserved Domains (1) summary
    cl14633
    Location:592
    DD; Death Domain Superfamily of protein-protein interaction domains
  2. NM_001276307.2NP_001263236.1  nucleolar protein 3 isoform MYP

    See identical proteins and their annotated locations for NP_001263236.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 encode the same protein (isoform MYP).
    Source sequence(s)
    AF064599, CB959673
    Consensus CDS
    CCDS42176.1
    UniProtKB/Swiss-Prot
    O60936
    UniProtKB/TrEMBL
    Q5TZN6
    Conserved Domains (1) summary
    cl14633
    Location:592
    DD; Death Domain Superfamily of protein-protein interaction domains
  3. NM_001276309.1NP_001263238.1  nucleolar protein 3 isoform MYP

    See identical proteins and their annotated locations for NP_001263238.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 encode the same protein (isoform MYP).
    Source sequence(s)
    AF064599, BP215200, CB959673
    Consensus CDS
    CCDS42176.1
    UniProtKB/Swiss-Prot
    O60936
    UniProtKB/TrEMBL
    Q5TZN6
    Related
    ENSP00000268605.7, ENST00000268605.11
    Conserved Domains (1) summary
    cl14633
    Location:592
    DD; Death Domain Superfamily of protein-protein interaction domains
  4. NM_001276311.1NP_001263240.1  nucleolar protein 3 isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in the CDS compared to variant 1. The resulting protein has the same N-terminus and then is frame-shifted resulting in a distinct C-terminus, compared to isoform MYP.
    Source sequence(s)
    AF064599, BF568452, DA928396
    UniProtKB/Swiss-Prot
    O60936
    Conserved Domains (2) summary
    cl00281
    Location:30115
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
    cl14633
    Location:558
    DD; Death Domain Superfamily of protein-protein interaction domains
  5. NM_001276312.2NP_001263241.1  nucleolar protein 3 isoform MYP

    See identical proteins and their annotated locations for NP_001263241.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform. Variants 1, 2, 4, and 5 encode the same protein (isoform MYP).
    Source sequence(s)
    AC074143, AF064599, AK294145
    Consensus CDS
    CCDS42176.1
    UniProtKB/Swiss-Prot
    O60936
    UniProtKB/TrEMBL
    Q5TZN6
    Conserved Domains (1) summary
    cl14633
    Location:592
    DD; Death Domain Superfamily of protein-protein interaction domains
  6. NM_001276319.2NP_001263248.1  nucleolar protein 3 isoform D

    See identical proteins and their annotated locations for NP_001263248.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is identical to variant 1 but represents possible translation from an upstream in-frame AUG codon which has a weak Kozak signal strength. The resulting isoform (D) has a longer and distinct N-terminus compared to isoform MYP. This protein product is inferred but is supported by conservation in some primate species.
    Source sequence(s)
    AC074143, AF064599, AK294145
    Consensus CDS
    CCDS61960.1
    UniProtKB/Swiss-Prot
    O60936
    Related
    ENSP00000457243.1, ENST00000564053.5
    Conserved Domains (1) summary
    cl14633
    Location:67154
    DD; Death Domain Superfamily of protein-protein interaction domains
  7. NM_003946.6NP_003937.1  nucleolar protein 3 isoform MYP

    See identical proteins and their annotated locations for NP_003937.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) originates from a different promoter and has a shorter 5' UTR, compared to variant 1. This transcript and protein were described by Stoss et al. (PMID: 10196175). Variants 1, 2, 4 and 5 encode the same protein (isoform MYP).
    Source sequence(s)
    AF064599, BQ685512
    Consensus CDS
    CCDS42176.1
    UniProtKB/Swiss-Prot
    O60936
    UniProtKB/TrEMBL
    Q5TZN6
    Conserved Domains (1) summary
    cl14633
    Location:592
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    67170497..67175737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523424.2XP_011521726.1  nucleolar protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011521726.1

    Conserved Domains (1) summary
    cl14633
    Location:592
    DD; Death Domain Superfamily of protein-protein interaction domains
  2. XM_005256217.3XP_005256274.1  nucleolar protein 3 isoform X2

    Conserved Domains (1) summary
    cl14633
    Location:67154
    DD; Death Domain Superfamily of protein-protein interaction domains
  3. XM_005256219.4XP_005256276.1  nucleolar protein 3 isoform X4

    Related
    ENSP00000455808.1, ENST00000566871.5
    Conserved Domains (2) summary
    cl00281
    Location:92177
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
    cl14633
    Location:67120
    DD; Death Domain Superfamily of protein-protein interaction domains
  4. XM_017023843.2XP_016879332.1  nucleolar protein 3 isoform X3

    UniProtKB/Swiss-Prot
    O60936
    Conserved Domains (1) summary
    cl14633
    Location:67154
    DD; Death Domain Superfamily of protein-protein interaction domains

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001185058.1: Suppressed sequence

    Description
    NM_001185058.1: This RefSeq has been replaced by NM_001276312.1.
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