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NOL3 nucleolar protein 3 [ Homo sapiens (human) ]

Gene ID: 8996, updated on 18-Sep-2024

Summary

Official Symbol
NOL3provided by HGNC
Official Full Name
nucleolar protein 3provided by HGNC
Primary source
HGNC:HGNC:7869
See related
Ensembl:ENSG00000140939 MIM:605235; AllianceGenome:HGNC:7869
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC; FCM; MYP; NOP; NOP30; MYOCL1
Summary
This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in skin (RPKM 15.7), prostate (RPKM 15.6) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NOL3 in Genome Data Viewer
Location:
16q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67170538..67175737)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72964831..72970031)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67204441..67209640)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67189519-67190420 Neighboring gene TNFRSF1A associated via death domain Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67195788-67196300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67196374-67197322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67197323-67198271 Neighboring gene F-box and leucine rich repeat protein 8 Neighboring gene Sharpr-MPRA regulatory region 11796 Neighboring gene heat shock transcription factor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7588 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67206328-67206491 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67207408-67208330 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67209861-67210290 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67211873-67212416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67212417-67212958 Neighboring gene microtubule associated tyrosine carboxypeptidase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10956 Neighboring gene exocyst complex component 3 like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67225781-67226711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10958 Neighboring gene E2F transcription factor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7593

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nucleolar protein 3, apoptosis repressor with CARD domain (NOL3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ35304

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding TAS
Traceable Author Statement
more info
PubMed 
enables calcium ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables caspase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables caspase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
enables death receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing TAS
Traceable Author Statement
more info
PubMed 
involved_in blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in inhibition of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splice site recognition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of mitochondrial membrane permeability involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of muscle atrophy IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of programmed necrotic cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of release of cytochrome c from mitochondria IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in protein complex oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of non-canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to injury involved in regulation of muscle adaptation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ischemia IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nucleolar protein 3
Names
muscle-enriched cytoplasmic protein
nucleolar protein 3 (apoptosis repressor with CARD domain)
nucleolar protein of 30 kDa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029566.1 RefSeqGene

    Range
    8352..10236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001185057.3NP_001171986.1  nucleolar protein 3 isoform Nop30

    See identical proteins and their annotated locations for NP_001171986.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) originates from a different promoter, has a shorter 5' UTR, and uses an alternate splice site in the CDS, compared to variant 1. This transcript and protein were described by Stoss et al. (PMID: 10196175). The resulting protein (Nop30) has the same N-terminus and then is frameshifted resulting in a distinct C-terminus, compared to isoform MYP.
    Source sequence(s)
    AC074143
    Consensus CDS
    CCDS58473.1
    UniProtKB/TrEMBL
    H3BQJ5
    Related
    ENSP00000454598.1, ENST00000568146.1
    Conserved Domains (1) summary
    cl14633
    Location:592
    DD; Death Domain Superfamily of protein-protein interaction domains
  2. NM_001276307.3NP_001263236.1  nucleolar protein 3 isoform MYP

    See identical proteins and their annotated locations for NP_001263236.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 encode the same protein (isoform MYP).
    Source sequence(s)
    AC074143
    Consensus CDS
    CCDS42176.1
    UniProtKB/Swiss-Prot
    B4DFL0, O60936, O60937
    UniProtKB/TrEMBL
    Q5TZN6
    Conserved Domains (1) summary
    cl14633
    Location:592
    DD; Death Domain Superfamily of protein-protein interaction domains
  3. NM_001276309.3NP_001263238.1  nucleolar protein 3 isoform MYP

    See identical proteins and their annotated locations for NP_001263238.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 encode the same protein (isoform MYP).
    Source sequence(s)
    AC074143
    Consensus CDS
    CCDS42176.1
    UniProtKB/Swiss-Prot
    B4DFL0, O60936, O60937
    UniProtKB/TrEMBL
    Q5TZN6
    Related
    ENSP00000457720.2, ENST00000564992.2
    Conserved Domains (1) summary
    cl14633
    Location:592
    DD; Death Domain Superfamily of protein-protein interaction domains
  4. NM_001276311.2NP_001263240.1  nucleolar protein 3 isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in the CDS compared to variant 1. The resulting protein has the same N-terminus and then is frame-shifted resulting in a distinct C-terminus, compared to isoform MYP.
    Source sequence(s)
    AC074143
    UniProtKB/TrEMBL
    H3BQJ5
    Related
    ENSP00000455808.1, ENST00000566871.5
    Conserved Domains (2) summary
    cl00281
    Location:30115
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
    cl14633
    Location:558
    DD; Death Domain Superfamily of protein-protein interaction domains
  5. NM_001276312.3NP_001263241.1  nucleolar protein 3 isoform MYP

    See identical proteins and their annotated locations for NP_001263241.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform. Variants 1, 2, 4, and 5 encode the same protein (isoform MYP).
    Source sequence(s)
    AC074143
    Consensus CDS
    CCDS42176.1
    UniProtKB/Swiss-Prot
    B4DFL0, O60936, O60937
    UniProtKB/TrEMBL
    Q5TZN6
    Related
    ENSP00000457243.2, ENST00000564053.5
    Conserved Domains (1) summary
    cl14633
    Location:592
    DD; Death Domain Superfamily of protein-protein interaction domains
  6. NM_001394973.1NP_001381902.1  nucleolar protein 3 isoform MYP

    Status: REVIEWED

    Source sequence(s)
    AC074143
    Consensus CDS
    CCDS42176.1
    UniProtKB/Swiss-Prot
    B4DFL0, O60936, O60937
    UniProtKB/TrEMBL
    Q5TZN6
    Conserved Domains (1) summary
    cl14633
    Location:592
    DD; Death Domain Superfamily of protein-protein interaction domains
  7. NM_001394974.1NP_001381903.1  nucleolar protein 3 isoform C

    Status: REVIEWED

    Source sequence(s)
    AC074143
    UniProtKB/TrEMBL
    H3BQJ5
    Conserved Domains (2) summary
    cl00281
    Location:30115
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
    cl14633
    Location:558
    DD; Death Domain Superfamily of protein-protein interaction domains
  8. NM_001394975.1NP_001381904.1  nucleolar protein 3 isoform C

    Status: REVIEWED

    Source sequence(s)
    AC074143
    UniProtKB/TrEMBL
    H3BQJ5
    Conserved Domains (2) summary
    cl00281
    Location:30115
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
    cl14633
    Location:558
    DD; Death Domain Superfamily of protein-protein interaction domains
  9. NM_001394976.1NP_001381905.1  nucleolar protein 3 isoform C

    Status: REVIEWED

    Source sequence(s)
    AC074143
    UniProtKB/TrEMBL
    H3BQJ5
    Conserved Domains (2) summary
    cl00281
    Location:30115
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
    cl14633
    Location:558
    DD; Death Domain Superfamily of protein-protein interaction domains
  10. NM_001394977.1NP_001381906.1  nucleolar protein 3 isoform Nop30

    Status: REVIEWED

    Source sequence(s)
    AC074143
    Consensus CDS
    CCDS58473.1
    UniProtKB/TrEMBL
    H3BQJ5
    Conserved Domains (1) summary
    cl14633
    Location:592
    DD; Death Domain Superfamily of protein-protein interaction domains
  11. NM_001394978.1NP_001381907.1  nucleolar protein 3 isoform Nop30

    Status: REVIEWED

    Source sequence(s)
    AC074143
    Consensus CDS
    CCDS58473.1
    UniProtKB/TrEMBL
    H3BQJ5
    Conserved Domains (1) summary
    cl14633
    Location:592
    DD; Death Domain Superfamily of protein-protein interaction domains
  12. NM_001394979.1NP_001381908.1  nucleolar protein 3 isoform E

    Status: REVIEWED

    Source sequence(s)
    AC074143
    Conserved Domains (1) summary
    cl14633
    Location:592
    DD; Death Domain Superfamily of protein-protein interaction domains
  13. NM_003946.7NP_003937.1  nucleolar protein 3 isoform MYP

    See identical proteins and their annotated locations for NP_003937.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) originates from a different promoter and has a shorter 5' UTR, compared to variant 1. This transcript and protein were described by Stoss et al. (PMID: 10196175). Variants 1, 2, 4 and 5 encode the same protein (isoform MYP).
    Source sequence(s)
    AC074143
    Consensus CDS
    CCDS42176.1
    UniProtKB/Swiss-Prot
    B4DFL0, O60936, O60937
    UniProtKB/TrEMBL
    Q5TZN6
    Related
    ENST00000568503.1
    Conserved Domains (1) summary
    cl14633
    Location:592
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    67170538..67175737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434851.1XP_047290807.1  nucleolar protein 3 isoform X2

  2. XM_047434852.1XP_047290808.1  nucleolar protein 3 isoform X3

    UniProtKB/Swiss-Prot
    B4DFL0, O60936, O60937
    UniProtKB/TrEMBL
    Q5TZN6
  3. XM_047434850.1XP_047290806.1  nucleolar protein 3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    72964831..72970031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314289.1XP_054170264.1  nucleolar protein 3 isoform X2

  2. XM_054314290.1XP_054170265.1  nucleolar protein 3 isoform X3

    UniProtKB/Swiss-Prot
    B4DFL0, O60936, O60937
    UniProtKB/TrEMBL
    Q5TZN6
  3. XM_054314288.1XP_054170263.1  nucleolar protein 3 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001185058.1: Suppressed sequence

    Description
    NM_001185058.1: This RefSeq has been replaced by NM_001276312.1.
  2. NM_001276319.2: Suppressed sequence

    Description
    NM_001276319.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.