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KLC4 kinesin light chain 4 [ Homo sapiens (human) ]

Gene ID: 89953, updated on 5-Sep-2021

Summary

Official Symbol
KLC4provided by HGNC
Official Full Name
kinesin light chain 4provided by HGNC
Primary source
HGNC:HGNC:21624
See related
Ensembl:ENSG00000137171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KNSL8; bA387M24.3
Expression
Ubiquitous expression in duodenum (RPKM 24.3), small intestine (RPKM 22.1) and 25 other tissues See more
Orthologs
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Genomic context

See KLC4 in Genome Data Viewer
Location:
6p21.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (43059631..43075093)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43027369..43042831)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 403, pseudogene Neighboring gene cullin 7 Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene Sharpr-MPRA regulatory region 10128 Neighboring gene KLC4 antisense RNA 1 Neighboring gene protein tyrosine kinase 7 (inactive) Neighboring gene serum response factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111777

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of kinesin complex IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinesin light chain 4
Names
kinesin-like protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289034.2NP_001275963.1  kinesin light chain 4 isoform a

    See identical proteins and their annotated locations for NP_001275963.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1, 2 and 5 encode the same isoform (a), which has a shorter N-terminus, compared to isoform b.
    Source sequence(s)
    AK056393, BC080637, BX640717
    Consensus CDS
    CCDS4883.1
    UniProtKB/Swiss-Prot
    Q9NSK0
    UniProtKB/TrEMBL
    A0A024RCZ8
    Related
    ENSP00000418031.1, ENST00000479388.5
    Conserved Domains (3) summary
    TIGR02168
    Location:33148
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294368
    TPR_12; Tetratricopeptide repeat
  2. NM_001289035.2NP_001275964.1  kinesin light chain 4 isoform d

    See identical proteins and their annotated locations for NP_001275964.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate 5' terminal exon, initiates translation at a downstream start codon and lacks an alternate in-frame exon in the 5' coding region, compared to variant 3. It encodes isoform d, which is shorter than isoform b.
    Source sequence(s)
    AK297433, BC080637
    Consensus CDS
    CCDS75459.1
    UniProtKB/Swiss-Prot
    Q9NSK0
    Related
    ENSP00000395806.2, ENST00000453940.6
    Conserved Domains (2) summary
    sd00006
    Location:218246
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:217291
    TPR_12; Tetratricopeptide repeat
  3. NM_138343.4NP_612352.1  kinesin light chain 4 isoform c

    See identical proteins and their annotated locations for NP_612352.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region and contains a 3' terminal exon that extends past a splice site, compared to variant 3. It encodes isoform c, which is shorter and has a distinct C-terminus, compared to isoform b.
    Source sequence(s)
    BC012357, DA782235
    Consensus CDS
    CCDS47429.1
    UniProtKB/Swiss-Prot
    Q9NSK0
    Related
    ENSP00000410358.2, ENST00000458460.6
    Conserved Domains (3) summary
    sd00006
    Location:212239
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:252292
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:208285
    TPR_12; Tetratricopeptide repeat
  4. NM_201521.3NP_958929.1  kinesin light chain 4 isoform a

    See identical proteins and their annotated locations for NP_958929.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1, 2 and 5 encode the same isoform (a), which has a shorter N-terminus, compared to isoform b.
    Source sequence(s)
    BC080637, DA782235
    Consensus CDS
    CCDS4883.1
    UniProtKB/Swiss-Prot
    Q9NSK0
    UniProtKB/TrEMBL
    A0A024RCZ8
    Related
    ENSP00000340221.5, ENST00000347162.10
    Conserved Domains (3) summary
    TIGR02168
    Location:33148
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294368
    TPR_12; Tetratricopeptide repeat
  5. NM_201522.3NP_958930.1  kinesin light chain 4 isoform a

    See identical proteins and their annotated locations for NP_958930.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1, 2 and 5 encode the same isoform (a), which has a shorter N-terminus, compared to isoform b.
    Source sequence(s)
    AK055293, AK056393, BC080637, DA835055
    Consensus CDS
    CCDS4883.1
    UniProtKB/Swiss-Prot
    Q9NSK0
    UniProtKB/TrEMBL
    A0A024RCZ8
    Related
    ENSP00000377620.2, ENST00000394056.6
    Conserved Domains (3) summary
    TIGR02168
    Location:33148
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294368
    TPR_12; Tetratricopeptide repeat
  6. NM_201523.3NP_958931.1  kinesin light chain 4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (b).
    Source sequence(s)
    AK094102, BC080637
    Consensus CDS
    CCDS4882.1
    UniProtKB/Swiss-Prot
    Q9NSK0
    Related
    ENSP00000259708.3, ENST00000259708.7
    Conserved Domains (3) summary
    sd00006
    Location:313341
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:312386
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:51166
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    43059631..43075093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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