Format

Send to:

Choose Destination

RHOT2 ras homolog family member T2 [ Homo sapiens (human) ]

Gene ID: 89941, updated on 11-Sep-2019

Summary

Official Symbol
RHOT2provided by HGNC
Official Full Name
ras homolog family member T2provided by HGNC
Primary source
HGNC:HGNC:21169
See related
Ensembl:ENSG00000140983 MIM:613889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RASL; ARHT2; MIRO2; MIRO-2; C16orf39
Summary
This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in spleen (RPKM 20.5), duodenum (RPKM 16.0) and 25 other tissues See more
Orthologs

Genomic context

See RHOT2 in Genome Data Viewer
Location:
16p13.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (668083..674174)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (718083..724174)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MAPK regulated corepressor interacting protein 2 Neighboring gene uncharacterized LOC105371038 Neighboring gene WD repeat domain 90 Neighboring gene uncharacterized LOC107984861 Neighboring gene uncharacterized LOC105371184 Neighboring gene rhomboid like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
NHGRI GWA Catalog

Pathways from BioSystems

  • Mitophagy - animal, organism-specific biosystem (from KEGG)
    Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Mitophagy - animal, conserved biosystem (from KEGG)
    Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial outer membrane permeabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
integral component of mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
colocalizes_with mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
mitochondrial Rho GTPase 2
Names
mitochondrial Rho (MIRO) GTPase 2
ras homolog gene family, member T2
NP_001339204.1
NP_001339205.1
NP_001339206.1
NP_001339207.1
NP_001339208.1
NP_001339209.1
NP_001339210.1
NP_001339211.1
NP_001339212.1
NP_001339213.1
NP_001339214.1
NP_001339215.1
NP_001339216.1
NP_001339217.1
NP_001339218.1
NP_001339219.1
NP_001339220.1
NP_001339221.1
NP_001339222.1
NP_001339223.1
NP_620124.1
XP_024306246.1
XP_024306247.1
XP_024306248.1
XP_024306249.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031824.1 RefSeqGene

    Range
    5050..11089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001352275.2NP_001339204.1  mitochondrial Rho GTPase 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (4) summary
    cd01892
    Location:414590
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:3169
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    pfam08355
    Location:342408
    EF_assoc_1; EF hand associated
    pfam08356
    Location:221306
    EF_assoc_2; EF hand associated
  2. NM_001352276.2NP_001339205.1  mitochondrial Rho GTPase 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (4) summary
    cd01892
    Location:396572
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:3151
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    pfam08355
    Location:324390
    EF_assoc_1; EF hand associated
    pfam08356
    Location:203288
    EF_assoc_2; EF hand associated
  3. NM_001352277.2NP_001339206.1  mitochondrial Rho GTPase 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (4) summary
    cd01892
    Location:395571
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:3151
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    pfam08355
    Location:323389
    EF_assoc_1; EF hand associated
    pfam08356
    Location:202287
    EF_assoc_2; EF hand associated
  4. NM_001352278.2NP_001339207.1  mitochondrial Rho GTPase 2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (4) summary
    cd01892
    Location:380556
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:3169
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    pfam08355
    Location:308374
    EF_assoc_1; EF hand associated
    pfam08356
    Location:187272
    EF_assoc_2; EF hand associated
  5. NM_001352279.2NP_001339208.1  mitochondrial Rho GTPase 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (4) summary
    cd01892
    Location:362538
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:3151
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    pfam08355
    Location:290356
    EF_assoc_1; EF hand associated
    pfam08356
    Location:169254
    EF_assoc_2; EF hand associated
  6. NM_001352280.2NP_001339209.1  mitochondrial Rho GTPase 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (4) summary
    cd01892
    Location:307483
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:235301
    EF_assoc_1; EF hand associated
    pfam08356
    Location:114199
    EF_assoc_2; EF hand associated
    cl21455
    Location:962
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  7. NM_001352281.2NP_001339210.1  mitochondrial Rho GTPase 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (4) summary
    cd01892
    Location:306482
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:234300
    EF_assoc_1; EF hand associated
    pfam08356
    Location:113198
    EF_assoc_2; EF hand associated
    cl21455
    Location:962
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  8. NM_001352282.2NP_001339211.1  mitochondrial Rho GTPase 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (4) summary
    cd01892
    Location:306482
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:234300
    EF_assoc_1; EF hand associated
    pfam08356
    Location:113198
    EF_assoc_2; EF hand associated
    cl21455
    Location:962
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  9. NM_001352283.2NP_001339212.1  mitochondrial Rho GTPase 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (4) summary
    cd01892
    Location:286462
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:214280
    EF_assoc_1; EF hand associated
    pfam08356
    Location:93178
    EF_assoc_2; EF hand associated
    cl21455
    Location:142
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  10. NM_001352284.2NP_001339213.1  mitochondrial Rho GTPase 2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (4) summary
    cd01892
    Location:274450
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:202268
    EF_assoc_1; EF hand associated
    pfam08356
    Location:81166
    EF_assoc_2; EF hand associated
    cl21455
    Location:962
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  11. NM_001352285.2NP_001339214.1  mitochondrial Rho GTPase 2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (4) summary
    cd01892
    Location:273449
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:201267
    EF_assoc_1; EF hand associated
    pfam08356
    Location:80165
    EF_assoc_2; EF hand associated
    cl21455
    Location:962
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  12. NM_001352286.2NP_001339215.1  mitochondrial Rho GTPase 2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (4) summary
    cd01892
    Location:254430
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:182248
    EF_assoc_1; EF hand associated
    pfam08356
    Location:61146
    EF_assoc_2; EF hand associated
    cl21455
    Location:142
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  13. NM_001352287.1NP_001339216.1  mitochondrial Rho GTPase 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL834163, Z92544
    Conserved Domains (3) summary
    cd01892
    Location:192368
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:120186
    EF_assoc_1; EF hand associated
    pfam08356
    Location:2884
    EF_assoc_2; EF hand associated
  14. NM_001352288.2NP_001339217.1  mitochondrial Rho GTPase 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (3) summary
    cd01892
    Location:192368
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:120186
    EF_assoc_1; EF hand associated
    pfam08356
    Location:2884
    EF_assoc_2; EF hand associated
  15. NM_001352289.2NP_001339218.1  mitochondrial Rho GTPase 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (3) summary
    cd01892
    Location:192368
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:120186
    EF_assoc_1; EF hand associated
    pfam08356
    Location:2884
    EF_assoc_2; EF hand associated
  16. NM_001352290.2NP_001339219.1  mitochondrial Rho GTPase 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (3) summary
    cd01892
    Location:192368
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:120186
    EF_assoc_1; EF hand associated
    pfam08356
    Location:2884
    EF_assoc_2; EF hand associated
  17. NM_001352291.2NP_001339220.1  mitochondrial Rho GTPase 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (3) summary
    cd01892
    Location:192368
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:120186
    EF_assoc_1; EF hand associated
    pfam08356
    Location:2884
    EF_assoc_2; EF hand associated
  18. NM_001352292.2NP_001339221.1  mitochondrial Rho GTPase 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (3) summary
    cd01892
    Location:192368
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:120186
    EF_assoc_1; EF hand associated
    pfam08356
    Location:2884
    EF_assoc_2; EF hand associated
  19. NM_001352293.2NP_001339222.1  mitochondrial Rho GTPase 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (3) summary
    cd01892
    Location:192368
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:120186
    EF_assoc_1; EF hand associated
    pfam08356
    Location:2884
    EF_assoc_2; EF hand associated
  20. NM_001352294.2NP_001339223.1  mitochondrial Rho GTPase 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Conserved Domains (3) summary
    cd01892
    Location:192368
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:120186
    EF_assoc_1; EF hand associated
    pfam08356
    Location:2884
    EF_assoc_2; EF hand associated
  21. NM_138769.3NP_620124.1  mitochondrial Rho GTPase 2 isoform 2

    See identical proteins and their annotated locations for NP_620124.1

    Status: REVIEWED

    Source sequence(s)
    AJ517413, AL834163, AY207375, DB465261
    Consensus CDS
    CCDS10417.1
    UniProtKB/Swiss-Prot
    Q8IXI1
    Related
    ENSP00000321971.4, ENST00000315082.9
    Conserved Domains (4) summary
    cd01892
    Location:413589
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:3169
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    pfam08355
    Location:341407
    EF_assoc_1; EF hand associated
    pfam08356
    Location:220305
    EF_assoc_2; EF hand associated

RNA

  1. NR_147953.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    Z92544
  2. NR_147954.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    Z92544
  3. NR_147955.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    Z92544
  4. NR_147956.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    Z92544
    Related
    ENST00000569675.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    668083..674174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450479.1XP_024306247.1  mitochondrial Rho GTPase 2 isoform X2

    Conserved Domains (3) summary
    cd01892
    Location:192368
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:120186
    EF_assoc_1; EF hand associated
    pfam08356
    Location:2884
    EF_assoc_2; EF hand associated
  2. XM_024450481.1XP_024306249.1  mitochondrial Rho GTPase 2 isoform X2

    Conserved Domains (3) summary
    cd01892
    Location:192368
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:120186
    EF_assoc_1; EF hand associated
    pfam08356
    Location:2884
    EF_assoc_2; EF hand associated
  3. XM_024450478.1XP_024306246.1  mitochondrial Rho GTPase 2 isoform X1

    Conserved Domains (4) summary
    cd01892
    Location:585761
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:513579
    EF_assoc_1; EF hand associated
    pfam08356
    Location:392477
    EF_assoc_2; EF hand associated
    cl21455
    Location:3341
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_024450480.1XP_024306248.1  mitochondrial Rho GTPase 2 isoform X2

    Conserved Domains (3) summary
    cd01892
    Location:192368
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:120186
    EF_assoc_1; EF hand associated
    pfam08356
    Location:2884
    EF_assoc_2; EF hand associated
Support Center