Format

Send to:

Choose Destination

PAPLN papilin, proteoglycan like sulfated glycoprotein [ Homo sapiens (human) ]

Gene ID: 89932, updated on 20-Dec-2019

Summary

Official Symbol
PAPLNprovided by HGNC
Official Full Name
papilin, proteoglycan like sulfated glycoproteinprovided by HGNC
Primary source
HGNC:HGNC:19262
See related
Ensembl:ENSG00000100767 MIM:617785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPN
Expression
Broad expression in spleen (RPKM 9.2), kidney (RPKM 8.9) and 22 other tissues See more
Orthologs

Genomic context

See PAPLN in Genome Data Viewer
Location:
14q24.2
Exon count:
31
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (73235841..73274623)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (73704205..73741348)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene required for meiotic nuclear division 1 homolog (S. cerevisiae) pseudogene Neighboring gene RNA binding motif protein 25 Neighboring gene presenilin 1 Neighboring gene uncharacterized LOC101928123 Neighboring gene RNA, U6 small nuclear 419, pseudogene Neighboring gene NUMB endocytic adaptor protein Neighboring gene uncharacterized LOC101928143

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC50452, DKFZp434F053

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365906.3NP_001352835.1  papilin isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC004846
    Related
    ENSP00000451803.1, ENST00000554301.5
    Conserved Domains (8) summary
    smart00209
    Location:2980
    TSP1; Thrombospondin type 1 repeats
    smart00409
    Location:11391219
    IG; Immunoglobulin
    pfam07679
    Location:10491119
    I-set; Immunoglobulin I-set domain
    pfam00014
    Location:753805
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam05986
    Location:183298
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:12351267
    PLAC; PLAC (protease and lacunin) domain
    pfam16626
    Location:814905
    Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
    cl11960
    Location:914978
    Ig; Immunoglobulin domain
  2. NM_001365907.2NP_001352836.1  papilin isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC004846
    Related
    ENSP00000451729.1, ENST00000555445.5
    Conserved Domains (8) summary
    smart00209
    Location:2980
    TSP1; Thrombospondin type 1 repeats
    smart00409
    Location:11231203
    IG; Immunoglobulin
    pfam07679
    Location:10331103
    I-set; Immunoglobulin I-set domain
    pfam00014
    Location:753789
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam05986
    Location:183298
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:12191251
    PLAC; PLAC (protease and lacunin) domain
    pfam16626
    Location:798889
    Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
    cl11960
    Location:898962
    Ig; Immunoglobulin domain
  3. NM_173462.4NP_775733.3  papilin isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC004846
    Consensus CDS
    CCDS32114.1
    UniProtKB/Swiss-Prot
    O95428
    UniProtKB/TrEMBL
    B3KXI1
    Related
    ENSP00000345395.5, ENST00000340738.9
    Conserved Domains (8) summary
    smart00408
    Location:10301089
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:2980
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:10231102
    IG_like; Immunoglobulin like
    pfam00014
    Location:726778
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam05986
    Location:197271
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:12081240
    PLAC; PLAC (protease and lacunin) domain
    pfam16626
    Location:787878
    Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
    cl11960
    Location:887951
    Ig; Immunoglobulin domain

RNA

  1. NR_158677.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004846
  2. NR_158678.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004846

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    73235841..73274623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537292.3XP_011535594.1  papilin isoform X1

    See identical proteins and their annotated locations for XP_011535594.1

    UniProtKB/Swiss-Prot
    O95428
    Conserved Domains (8) summary
    smart00209
    Location:2980
    TSP1; Thrombospondin type 1 repeats
    smart00409
    Location:11391219
    IG; Immunoglobulin
    pfam07679
    Location:10491119
    I-set; Immunoglobulin I-set domain
    pfam00014
    Location:753805
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam05986
    Location:183298
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:12351267
    PLAC; PLAC (protease and lacunin) domain
    pfam16626
    Location:814905
    Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
    cl11960
    Location:914978
    Ig; Immunoglobulin domain
  2. XM_011537291.3XP_011535593.1  papilin isoform X1

    See identical proteins and their annotated locations for XP_011535593.1

    UniProtKB/Swiss-Prot
    O95428
    Conserved Domains (8) summary
    smart00209
    Location:2980
    TSP1; Thrombospondin type 1 repeats
    smart00409
    Location:11391219
    IG; Immunoglobulin
    pfam07679
    Location:10491119
    I-set; Immunoglobulin I-set domain
    pfam00014
    Location:753805
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam05986
    Location:183298
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:12351267
    PLAC; PLAC (protease and lacunin) domain
    pfam16626
    Location:814905
    Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
    cl11960
    Location:914978
    Ig; Immunoglobulin domain
  3. XM_011537295.3XP_011535597.1  papilin isoform X4

    Conserved Domains (9) summary
    cd00096
    Location:10681144
    Ig; Immunoglobulin domain
    smart00209
    Location:3687
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:9231001
    IG_like; Immunoglobulin like
    pfam07679
    Location:10561147
    I-set; Immunoglobulin I-set domain
    pfam00014
    Location:760812
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam05986
    Location:190305
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:11631195
    PLAC; PLAC (protease and lacunin) domain
    pfam16626
    Location:821912
    Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
    cl11960
    Location:921985
    Ig; Immunoglobulin domain
  4. XM_011537293.3XP_011535595.1  papilin isoform X2

    Conserved Domains (7) summary
    smart00408
    Location:10641123
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:3687
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:10571136
    IG_like; Immunoglobulin like
    pfam00014
    Location:760812
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam05986
    Location:190305
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam16626
    Location:821912
    Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
    cl11960
    Location:921985
    Ig; Immunoglobulin domain
  5. XM_017021749.2XP_016877238.1  papilin isoform X5

  6. XM_011537296.2XP_011535598.1  papilin isoform X7

    Related
    ENSP00000452455.1, ENST00000555123.5
    Conserved Domains (6) summary
    smart00209
    Location:3687
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:9231001
    IG_like; Immunoglobulin like
    pfam00014
    Location:760812
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam05986
    Location:190305
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam16626
    Location:821912
    Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
    cl11960
    Location:921985
    Ig; Immunoglobulin domain
  7. XM_011537294.3XP_011535596.1  papilin isoform X3

    Conserved Domains (8) summary
    smart00408
    Location:10131072
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:264317
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:10061085
    IG_like; Immunoglobulin like
    pfam00014
    Location:709761
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam05986
    Location:139254
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:11911223
    PLAC; PLAC (protease and lacunin) domain
    pfam16626
    Location:770861
    Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
    cl11960
    Location:870934
    Ig; Immunoglobulin domain

RNA

  1. XR_429333.3 RNA Sequence

Support Center