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PGLYRP1 peptidoglycan recognition protein 1 [ Homo sapiens (human) ]

Gene ID: 8993, updated on 7-Dec-2018

Summary

Official Symbol
PGLYRP1provided by HGNC
Official Full Name
peptidoglycan recognition protein 1provided by HGNC
Primary source
HGNC:HGNC:8904
See related
Ensembl:ENSG00000008438 MIM:604963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGRP; TAG7; PGRPS; PGLYRP; PGRP-S; TNFSF3L
Expression
Restricted expression toward bone marrow (RPKM 135.5) See more
Orthologs

Genomic context

See PGLYRP1 in Genome Data Viewer
Location:
19q13.32
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (46019153..46023298, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46522411..46526556, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 61 Neighboring gene microRNA 769 Neighboring gene uncharacterized LOC105372421 Neighboring gene IGF like family member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Antimicrobial peptides, organism-specific biosystem (from REACTOME)
    Antimicrobial peptides, organism-specific biosystemAntimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum of antimicrobial activity against bacteria, viruses, and fungi (Zasloff M 2002; Radek K & Gallo R 2007). The majo...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126894, MGC126896

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetylmuramoyl-L-alanine amidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidoglycan receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidoglycan receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antimicrobial humoral immune response mediated by antimicrobial peptide IDA
Inferred from Direct Assay
more info
PubMed 
antimicrobial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antimicrobial humoral response TAS
Traceable Author Statement
more info
 
defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
detection of bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
detection of bacterium IDA
Inferred from Direct Assay
more info
PubMed 
growth of symbiont in host IEA
Inferred from Electronic Annotation
more info
 
innate immune response NAS
Non-traceable Author Statement
more info
PubMed 
killing of cells of other organism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
killing of cells of other organism IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interferon-gamma production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of natural killer cell differentiation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
pattern recognition receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytolysis in other organism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytolysis in other organism IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytic vesicle lumen TAS
Traceable Author Statement
more info
 
specific granule lumen TAS
Traceable Author Statement
more info
 
tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
peptidoglycan recognition protein 1
Names
TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005091.3NP_005082.1  peptidoglycan recognition protein 1 precursor

    See identical proteins and their annotated locations for NP_005082.1

    Status: VALIDATED

    Source sequence(s)
    AF242517, DN998360
    Consensus CDS
    CCDS12680.1
    UniProtKB/Swiss-Prot
    O75594
    Related
    ENSP00000008938.3, ENST00000008938.4
    Conserved Domains (1) summary
    smart00701
    Location:31173
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    46019153..46023298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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