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SELENBP1 selenium binding protein 1 [ Homo sapiens (human) ]

Gene ID: 8991, updated on 29-Mar-2020

Summary

Official Symbol
SELENBP1provided by HGNC
Official Full Name
selenium binding protein 1provided by HGNC
Primary source
HGNC:HGNC:10719
See related
Ensembl:ENSG00000143416 MIM:604188
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTO; LPSB; SP56; hSBP; EHMTO; SBP56; HEL-S-134P
Summary
This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
Expression
Broad expression in colon (RPKM 232.0), lung (RPKM 124.7) and 17 other tissues See more
Orthologs

Genomic context

See SELENBP1 in Genome Data Viewer
Location:
1q21.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (151364304..151372725, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151336778..151345210, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 4-kinase beta Neighboring gene Sharpr-MPRA regulatory region 1421 Neighboring gene RFX5 antisense RNA 1 Neighboring gene regulatory factor X5 Neighboring gene proteasome 20S subunit beta 4 Neighboring gene pogo transposable element derived with ZNF domain Neighboring gene RNY4 pseudogene 25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
EXTRAORAL HALITOSIS DUE TO METHANETHIOL OXIDASE DEFICIENCY
MedGen: C4748387 OMIM: 618148 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13813

Gene Ontology Provided by GOA

Function Evidence Code Pubs
methanethiol oxidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
selenium binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
fibrillar center IDA
Inferred from Direct Assay
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
methanethiol oxidase
Names
56 kDa selenium-binding protein
epididymis secretory sperm binding protein Li 134P
NP_001245217.1
NP_001245218.1
NP_003935.2
XP_024306439.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258288.2NP_001245217.1  methanethiol oxidase isoform 2

    See identical proteins and their annotated locations for NP_001245217.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK303815, BQ045424, DB288439
    Consensus CDS
    CCDS58027.1
    UniProtKB/Swiss-Prot
    Q13228
    Related
    ENSP00000413960.3, ENST00000447402.7
    Conserved Domains (1) summary
    pfam05694
    Location:7410
    SBP56; 56kDa selenium binding protein (SBP56)
  2. NM_001258289.2NP_001245218.1  methanethiol oxidase isoform 3

    See identical proteins and their annotated locations for NP_001245218.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK296661, BQ045424, CR456852, DB288439
    Consensus CDS
    CCDS60266.1
    UniProtKB/Swiss-Prot
    Q13228
    Related
    ENSP00000397261.2, ENST00000426705.6
    Conserved Domains (1) summary
    pfam05694
    Location:49514
    SBP56; 56kDa selenium binding protein (SBP56)
  3. NM_003944.4NP_003935.2  methanethiol oxidase isoform 1

    See identical proteins and their annotated locations for NP_003935.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC009084, DB288439
    Consensus CDS
    CCDS995.1
    UniProtKB/Swiss-Prot
    Q13228
    UniProtKB/TrEMBL
    V9HWG1
    Related
    ENSP00000357861.5, ENST00000368868.10
    Conserved Domains (1) summary
    pfam05694
    Location:7472
    SBP56; 56kDa selenium binding protein (SBP56)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    151364304..151372725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450671.1XP_024306439.1  methanethiol oxidase isoform X1

    Related
    ENST00000470345.5
    Conserved Domains (1) summary
    pfam05694
    Location:1274
    SBP56; 56kDa selenium binding protein (SBP56)

RNA

  1. XR_002957987.1 RNA Sequence

  2. XR_921993.2 RNA Sequence

    Related
    ENST00000423070.5
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