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TMEM116 transmembrane protein 116 [ Homo sapiens (human) ]

Gene ID: 89894, updated on 11-Jun-2021

Summary

Official Symbol
TMEM116provided by HGNC
Official Full Name
transmembrane protein 116provided by HGNC
Primary source
HGNC:HGNC:25084
See related
Ensembl:ENSG00000198270
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 7.8), kidney (RPKM 3.9) and 23 other tissues See more
Orthologs
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Genomic context

See TMEM116 in Genome Data Viewer
Location:
12q24.12-q24.13
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (111894880..112013219, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (112369086..112451023, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene MAPKAPK5 antisense RNA 1 Neighboring gene MAPK activated protein kinase 5 Neighboring gene ribosomal protein S2 pseudogene 41 Neighboring gene ADAM metallopeptidase domain 1A (pseudogene) Neighboring gene ADAM metallopeptidase domain 1B (pseudogene) Neighboring gene solute carrier family 25 member 3 pseudogene 2 Neighboring gene immediate early response 3 interacting protein 1 pseudogene Neighboring gene endoplasmic reticulum protein 29 Neighboring gene N-alpha-acetyltransferase 25, NatB auxiliary subunit Neighboring gene microRNA 3657

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11466, FLJ35513, FLJ90167

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193453.2NP_001180382.1  transmembrane protein 116 isoform 2

    See identical proteins and their annotated locations for NP_001180382.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC004024, AC073575, BC000282, BI828772
    Consensus CDS
    CCDS55886.1
    UniProtKB/Swiss-Prot
    Q8NCL8
    UniProtKB/TrEMBL
    Q9BWF8
    Related
    ENSP00000347620.2, ENST00000355445.7
    Conserved Domains (2) summary
    cd14964
    Location:191215
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:143250
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_001193531.2NP_001180460.1  transmembrane protein 116 isoform 1

    See identical proteins and their annotated locations for NP_001180460.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC004024, AC073575, BC048796, BF435254, BI828772
    Consensus CDS
    CCDS55887.1
    UniProtKB/Swiss-Prot
    Q8NCL8
    Related
    ENSP00000447731.1, ENST00000552374.7
    Conserved Domains (2) summary
    cd14964
    Location:226250
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:178285
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. NM_001294314.2NP_001281243.1  transmembrane protein 116 isoform 3

    See identical proteins and their annotated locations for NP_001281243.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains two alternate exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AC004024, AK074648, BF435254, BI828772, DB030882
    Consensus CDS
    CCDS9157.1
    UniProtKB/Swiss-Prot
    Q8NCL8
    Conserved Domains (2) summary
    cd14964
    Location:134158
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:86193
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. NM_138341.3NP_612350.1  transmembrane protein 116 isoform 3

    See identical proteins and their annotated locations for NP_612350.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AC004024, AC073575, BC070135, BF435254, BI828772
    Consensus CDS
    CCDS9157.1
    UniProtKB/Swiss-Prot
    Q8NCL8
    Related
    ENSP00000450377.1, ENST00000550831.7
    Conserved Domains (2) summary
    cd14964
    Location:134158
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:86193
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. NR_122119.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL519857, BF435254, BI828772, DB030882
    Related
    ENST00000549537.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    111894880..112013219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538948.3XP_011537250.1  transmembrane protein 116 isoform X6

  2. XM_017020187.2XP_016875676.1  transmembrane protein 116 isoform X10

  3. XM_024449262.1XP_024305030.1  transmembrane protein 116 isoform X8

  4. XM_024449267.1XP_024305035.1  transmembrane protein 116 isoform X15

    Conserved Domains (2) summary
    cd14964
    Location:111135
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:63170
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  5. XM_024449264.1XP_024305032.1  transmembrane protein 116 isoform X12

    Conserved Domains (2) summary
    cd14964
    Location:163187
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:115222
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  6. XM_024449268.1XP_024305036.1  transmembrane protein 116 isoform X15

    Conserved Domains (2) summary
    cd14964
    Location:111135
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:63170
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  7. XM_024449265.1XP_024305033.1  transmembrane protein 116 isoform X13

    Conserved Domains (2) summary
    cd14964
    Location:134158
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:86193
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  8. XM_024449263.1XP_024305031.1  transmembrane protein 116 isoform X12

    Conserved Domains (2) summary
    cd14964
    Location:163187
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:115222
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  9. XM_017020188.2XP_016875677.1  transmembrane protein 116 isoform X12

    Conserved Domains (2) summary
    cd14964
    Location:163187
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:115222
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  10. XM_017020192.2XP_016875681.1  transmembrane protein 116 isoform X13

    UniProtKB/Swiss-Prot
    Q8NCL8
    Conserved Domains (2) summary
    cd14964
    Location:134158
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:86193
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  11. XM_011538958.1XP_011537260.1  transmembrane protein 116 isoform X15

    Conserved Domains (2) summary
    cd14964
    Location:111135
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:63170
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  12. XM_011538957.1XP_011537259.1  transmembrane protein 116 isoform X13

    See identical proteins and their annotated locations for XP_011537259.1

    UniProtKB/Swiss-Prot
    Q8NCL8
    Conserved Domains (2) summary
    cd14964
    Location:134158
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:86193
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  13. XM_011538953.1XP_011537255.1  transmembrane protein 116 isoform X12

    See identical proteins and their annotated locations for XP_011537255.1

    Conserved Domains (2) summary
    cd14964
    Location:163187
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:115222
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  14. XM_024449257.1XP_024305025.1  transmembrane protein 116 isoform X1

    Conserved Domains (2) summary
    cd14940
    Location:283307
    7tmE_cAMP_R_Slime_mold; TM helix 6 [structural motif]
    cl28897
    Location:235342
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  15. XM_024449261.1XP_024305029.1  transmembrane protein 116 isoform X11

  16. XM_024449259.1XP_024305027.1  transmembrane protein 116 isoform X3

    Conserved Domains (2) summary
    cd14940
    Location:260284
    7tmE_cAMP_R_Slime_mold; TM helix 6 [structural motif]
    cl28897
    Location:212319
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  17. XM_011538951.2XP_011537253.1  transmembrane protein 116 isoform X9

    Conserved Domains (2) summary
    cd14964
    Location:209233
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:161268
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  18. XM_024449258.1XP_024305026.1  transmembrane protein 116 isoform X2

    Conserved Domains (2) summary
    cd14940
    Location:277301
    7tmE_cAMP_R_Slime_mold; TM helix 6 [structural motif]
    cl28897
    Location:229336
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  19. XM_006719678.3XP_006719741.1  transmembrane protein 116 isoform X4

    Conserved Domains (2) summary
    cd14964
    Location:253277
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:205312
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  20. XM_024449266.1XP_024305034.1  transmembrane protein 116 isoform X14

  21. XM_017020190.2XP_016875679.1  transmembrane protein 116 isoform X13

    UniProtKB/Swiss-Prot
    Q8NCL8
    Conserved Domains (2) summary
    cd14964
    Location:134158
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:86193
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  22. XM_024449260.1XP_024305028.1  transmembrane protein 116 isoform X7

    Conserved Domains (2) summary
    cd14964
    Location:226250
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:178285
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  23. XM_011538949.2XP_011537251.1  transmembrane protein 116 isoform X7

    See identical proteins and their annotated locations for XP_011537251.1

    UniProtKB/Swiss-Prot
    Q8NCL8
    Conserved Domains (2) summary
    cd14964
    Location:226250
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:178285
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  24. XM_011538947.2XP_011537249.1  transmembrane protein 116 isoform X5

    See identical proteins and their annotated locations for XP_011537249.1

    UniProtKB/Swiss-Prot
    Q8NCL8
    Conserved Domains (2) summary
    cd14964
    Location:191215
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:143250
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  25. XM_011538950.2XP_011537252.1  transmembrane protein 116 isoform X8

RNA

  1. XR_001748914.2 RNA Sequence

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