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ZNF628 zinc finger protein 628 [ Homo sapiens (human) ]

Gene ID: 89887, updated on 7-Jun-2020

Summary

Official Symbol
ZNF628provided by HGNC
Official Full Name
zinc finger protein 628provided by HGNC
Primary source
HGNC:HGNC:28054
See related
Ensembl:ENSG00000197483 MIM:610671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZEC; Zfp628
Summary
Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. See ZNF91 (MIM 603971) for general information on ZNFs.[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 3.1), spleen (RPKM 1.1) and 24 other tissues See more
Orthologs

Genomic context

See ZNF628 in Genome Data Viewer
Location:
19q13.42
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (55476603..55484487)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55987699..55995854)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene shisa family member 7 Neighboring gene isochorismatase domain containing 2 Neighboring gene N-acetyltransferase 14 (putative) Neighboring gene scavenger receptor cysteine rich family member with 5 domains

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC105139

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 628
Names
zinc finger protein Zec

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033113.3NP_149104.3  zinc finger protein 628

    See identical proteins and their annotated locations for NP_149104.3

    Status: VALIDATED

    Source sequence(s)
    AC008735, BC016036, BC089449
    Consensus CDS
    CCDS33116.3
    UniProtKB/Swiss-Prot
    Q5EBL2
    Related
    ENSP00000469591.1, ENST00000598519.2
    Conserved Domains (4) summary
    COG5048
    Location:43213
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:150170
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:361378
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:204226
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    55476603..55484487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259371.3XP_005259428.1  zinc finger protein 628 isoform X2

    Related
    ENSP00000375598.3, ENST00000391718.3
    Conserved Domains (5) summary
    COG5048
    Location:39209
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:146166
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:357374
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:618640
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:576601
    zf-H2C2_2; Zinc-finger double domain
  2. XM_024451752.1XP_024307520.1  zinc finger protein 628 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:43213
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:150170
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:361378
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:204226
    zf-C2H2; Zinc finger, C2H2 type
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