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SLAMF9 SLAM family member 9 [ Homo sapiens (human) ]

Gene ID: 89886, updated on 21-Dec-2019

Summary

Official Symbol
SLAMF9provided by HGNC
Official Full Name
SLAM family member 9provided by HGNC
Primary source
HGNC:HGNC:18430
See related
Ensembl:ENSG00000162723 MIM:608589
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD2F10; CD84H1; SF2001; CD2F-10; CD84-H1
Summary
This gene encodes a member of the signaling lymphocytic activation molecule family. The encoded protein is a cell surface molecule that consists of two extracellular immunoglobulin domains, a transmembrane domain and a short cytoplasmic tail that lacks the signal transduction motifs found in other family members. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
Expression
Biased expression in stomach (RPKM 3.8), small intestine (RPKM 2.6) and 7 other tissues See more
Orthologs

Genomic context

See SLAMF9 in Genome Data Viewer
Location:
1q23.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (159951492..159984730, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159921282..159924044, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transgelin 2 Neighboring gene immunoglobulin superfamily member 9 Neighboring gene long intergenic non-protein coding RNA 1133 Neighboring gene Fc receptor like 6 pseudogene 1 Neighboring gene ribosomal protein L27a pseudogene 2 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class M

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • MGC88194

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SLAM family member 9
Names
CD2 family member 10
CD84 homolog 1
cluster of differentiation 2 antigen family member 10
cluster of differentiation 84 homolog 1
signaling lymphocytic activation molecule family member 2001
signaling lymphocytic activation molecule family member 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146172.2NP_001139644.1  SLAM family member 9 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL513485, AY034613, AY358801, CB528634
    Consensus CDS
    CCDS53392.1
    UniProtKB/Swiss-Prot
    Q96A28
    Related
    ENSP00000357071.3, ENST00000368092.7
    Conserved Domains (1) summary
    cd05775
    Location:33130
    Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
  2. NM_001146173.2NP_001139645.1  SLAM family member 9 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AY034613, BC070213, CB528634
    UniProtKB/Swiss-Prot
    Q96A28
    UniProtKB/TrEMBL
    Q6NSE6
    Conserved Domains (1) summary
    cl11960
    Location:3386
    Ig; Immunoglobulin domain
  3. NM_033438.4NP_254273.2  SLAM family member 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_254273.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL513485, AY034613, CB528634
    Consensus CDS
    CCDS1191.1
    UniProtKB/Swiss-Prot
    Q96A28
    Related
    ENSP00000357072.3, ENST00000368093.4
    Conserved Domains (2) summary
    cd05775
    Location:33130
    Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
    pfam13927
    Location:135204
    Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    159951492..159984730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002756.1XP_016858245.1  SLAM family member 9 isoform X1

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