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SLAMF9 SLAM family member 9 [ Homo sapiens (human) ]

Gene ID: 89886, updated on 18-Sep-2024

Summary

Official Symbol
SLAMF9provided by HGNC
Official Full Name
SLAM family member 9provided by HGNC
Primary source
HGNC:HGNC:18430
See related
Ensembl:ENSG00000162723 MIM:608589; AllianceGenome:HGNC:18430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD2F10; CD84H1; SF2001; CD2F-10; CD84-H1
Summary
This gene encodes a member of the signaling lymphocytic activation molecule family. The encoded protein is a cell surface molecule that consists of two extracellular immunoglobulin domains, a transmembrane domain and a short cytoplasmic tail that lacks the signal transduction motifs found in other family members. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
Expression
Biased expression in stomach (RPKM 3.8), small intestine (RPKM 2.6) and 7 other tissues See more
Orthologs
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Genomic context

See SLAMF9 in Genome Data Viewer
Location:
1q23.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (159951492..159983984, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (159088558..159121055, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159921282..159924027, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904437 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:159893727-159894926 Neighboring gene transgelin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159904768-159905268 Neighboring gene immunoglobulin superfamily member 9 Neighboring gene uncharacterized LOC124904438 Neighboring gene Sharpr-MPRA regulatory region 11999 Neighboring gene long intergenic non-protein coding RNA 1133 Neighboring gene Fc receptor like 6 pseudogene 1 Neighboring gene uncharacterized LOC124904436 Neighboring gene ribosomal protein L27a pseudogene 2 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class M

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC88194

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
SLAM family member 9
Names
CD2 family member 10
CD84 homolog 1
cluster of differentiation 2 antigen family member 10
cluster of differentiation 84 homolog 1
signaling lymphocytic activation molecule family member 2001
signaling lymphocytic activation molecule family member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146172.2NP_001139644.1  SLAM family member 9 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL513485, AY034613, AY358801, CB528634
    Consensus CDS
    CCDS53392.1
    UniProtKB/Swiss-Prot
    Q96A28
    Related
    ENSP00000357071.3, ENST00000368092.7
    Conserved Domains (1) summary
    cd05775
    Location:33130
    Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
  2. NM_001146173.2NP_001139645.1  SLAM family member 9 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AY034613, BC070213, CB528634
    UniProtKB/Swiss-Prot
    Q96A28
    UniProtKB/TrEMBL
    Q6NSE6
    Related
    ENST00000489098.1
    Conserved Domains (2) summary
    cd00096
    Location:3842
    Ig; Ig strand B [structural motif]
    cl11960
    Location:2986
    Ig; Immunoglobulin domain
  3. NM_033438.4NP_254273.2  SLAM family member 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_254273.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL513485, AY034613, CB528634
    Consensus CDS
    CCDS1191.1
    UniProtKB/Swiss-Prot
    Q5JRQ9, Q5JRR0, Q6UWG1, Q96A28
    Related
    ENSP00000357072.3, ENST00000368093.4
    Conserved Domains (2) summary
    cd05775
    Location:33130
    Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
    pfam13927
    Location:135204
    Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    159951492..159983984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002756.2XP_016858245.1  SLAM family member 9 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    159088558..159121055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339486.1XP_054195461.1  SLAM family member 9 isoform X1