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FATE1 fetal and adult testis expressed 1 [ Homo sapiens (human) ]

Gene ID: 89885, updated on 2-Mar-2021

Summary

Official Symbol
FATE1provided by HGNC
Official Full Name
fetal and adult testis expressed 1provided by HGNC
Primary source
HGNC:HGNC:24683
See related
Ensembl:ENSG00000147378 MIM:300450
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT43; FATE
Summary
This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation. [provided by RefSeq, Jan 2010]
Expression
Restricted expression toward testis (RPKM 120.2) See more
Orthologs
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Genomic context

See FATE1 in Genome Data Viewer
Location:
Xq28
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (151716035..151723194)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (150884507..150891666)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene PAS domain containing repressor 1 Neighboring gene proline rich and Gla domain 3 Neighboring gene cyclic nucleotide gated channel subunit alpha 2 Neighboring gene MAGEA4 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of fetal and adult testis expressed 1 (FATE1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mitochondrial calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of mitochondrial calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondria-associated endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondria-associated endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fetal and adult testis-expressed transcript protein
Names
BJ-HCC-2 antigen
cancer/testis antigen 43
tumor antigen BJ-HCC-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016398.1 RefSeqGene

    Range
    5000..12159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_033085.3NP_149076.1  fetal and adult testis-expressed transcript protein

    See identical proteins and their annotated locations for NP_149076.1

    Status: REVIEWED

    Source sequence(s)
    AF002992, AY101182
    Consensus CDS
    CCDS14700.1
    UniProtKB/Swiss-Prot
    Q969F0
    Related
    ENSP00000359375.3, ENST00000370350.7
    Conserved Domains (1) summary
    pfam05644
    Location:113182
    Miff; Mitochondrial and peroxisomal fission factor Mff

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    151716035..151723194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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