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PLCZ1 phospholipase C zeta 1 [ Homo sapiens (human) ]

Gene ID: 89869, updated on 13-Mar-2020

Summary

Official Symbol
PLCZ1provided by HGNC
Official Full Name
phospholipase C zeta 1provided by HGNC
Primary source
HGNC:HGNC:19218
See related
Ensembl:ENSG00000139151 MIM:608075
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPGF17; PLCzeta; NYD-SP27; PLC-zeta-1
Summary
The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Expression
Restricted expression toward testis (RPKM 5.9) See more
Orthologs

Genomic context

See PLCZ1 in Genome Data Viewer
Location:
12p12.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (18645529..18738052, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (18836110..18891020, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma Neighboring gene Nedd4 family interacting protein 1 pseudogene 1 Neighboring gene zinc finger with KRAB and SCAN domains 7 pseudogene 1 Neighboring gene proteasome 26S subunit, ATPase 1 pseudogene 9 Neighboring gene uncharacterized LOC102724227 Neighboring gene capping actin protein of muscle Z-line subunit alpha 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
Tat tat Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC149685

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol phospholipase C activity NAS
Non-traceable Author Statement
more info
PubMed 
phosphatidylinositol-3-phosphate binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-5-phosphate binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
egg activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
inositol trisphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytosolic calcium ion concentration involved in egg activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration involved in egg activation IDA
Inferred from Direct Assay
more info
PubMed 
release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
pronucleus IEA
Inferred from Electronic Annotation
more info
 
sperm head IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Names
PI-phospholipase C zeta 1
phosphoinositide phospholipase C-zeta-1
testicular tissue protein Li 145
testis-development related NYD-SP27
NP_001317698.1
NP_001317703.1
NP_149114.2
XP_005253576.1
XP_016875665.1
XP_016875666.1
XP_016875667.1
XP_016875668.1
XP_016875669.1
XP_016875670.1
XP_016875671.1
XP_016875672.1
XP_016875673.1
XP_016875674.1
XP_016875675.1
XP_024305021.1
XP_024305022.1
XP_024305023.1
XP_024305024.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052826.1 RefSeqGene

    Range
    5048..59880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330769.1NP_001317698.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks three consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter, but has the same N- and C-termini as isoform 1.
    Source sequence(s)
    AA812556, BC125067, DB038101
    Consensus CDS
    CCDS81671.1
    UniProtKB/Swiss-Prot
    Q86YW0
    Related
    ENSP00000445026.1, ENST00000539875.5
    Conserved Domains (4) summary
    cd00275
    Location:288413
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd15898
    Location:132
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl14615
    Location:35259
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl28895
    Location:148
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
  2. NM_001330774.2NP_001317703.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA812556, AK314516, BC125067
    UniProtKB/Swiss-Prot
    Q86YW0
  3. NM_033123.4NP_149114.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform 1

    See identical proteins and their annotated locations for NP_149114.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF532185, DB038101, HY197954
    Consensus CDS
    CCDS8680.1
    UniProtKB/Swiss-Prot
    Q86YW0
    UniProtKB/TrEMBL
    A0A140VJR9
    Related
    ENSP00000266505.7, ENST00000266505.12
    Conserved Domains (4) summary
    cd00275
    Location:481606
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08595
    Location:154452
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
    PLN02952
    Location:71607
    PLN02952; phosphoinositide phospholipase C
    pfam09279
    Location:72154
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    18645529..18738052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020178.1XP_016875667.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X4

  2. XM_017020177.1XP_016875666.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

  3. XM_017020176.1XP_016875665.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1

  4. XM_017020183.1XP_016875672.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X7

  5. XM_024449256.1XP_024305024.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X11

    Conserved Domains (2) summary
    cd00275
    Location:263386
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cl14615
    Location:1234
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  6. XM_017020186.1XP_016875675.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X12

  7. XM_017020181.1XP_016875670.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X5

    Conserved Domains (2) summary
    cd08595
    Location:50389
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
    cl27705
    Location:16543
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
  8. XM_017020179.1XP_016875668.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X5

    Conserved Domains (2) summary
    cd08595
    Location:50389
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
    cl27705
    Location:16543
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
  9. XM_024449253.1XP_024305021.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X5

    Conserved Domains (2) summary
    cd08595
    Location:50389
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
    cl27705
    Location:16543
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
  10. XM_017020180.1XP_016875669.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X5

    Conserved Domains (2) summary
    cd08595
    Location:50389
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
    cl27705
    Location:16543
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
  11. XM_017020185.2XP_016875674.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X11

    Conserved Domains (2) summary
    cd00275
    Location:263386
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cl14615
    Location:1234
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  12. XM_017020184.1XP_016875673.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X9

  13. XM_017020182.1XP_016875671.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X6

  14. XM_005253519.2XP_005253576.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X2

    Related
    ENSP00000497636.1, ENST00000648272.1
    Conserved Domains (4) summary
    cd00275
    Location:522647
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08595
    Location:154493
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
    PLN02952
    Location:71648
    PLN02952; phosphoinositide phospholipase C
    pfam09279
    Location:72154
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  15. XM_024449255.1XP_024305023.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X10

    Conserved Domains (4) summary
    cd00275
    Location:288413
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd15898
    Location:132
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl14615
    Location:35259
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl28895
    Location:148
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
  16. XM_024449254.1XP_024305022.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X8

    Related
    ENSP00000445880.1, ENST00000538330.5
    Conserved Domains (2) summary
    cl14615
    Location:3305
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl27705
    Location:3460
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

RNA

  1. XR_001748912.1 RNA Sequence

  2. XR_001748913.1 RNA Sequence

    Related
    ENST00000318197.10
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