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RPS6KA4 ribosomal protein S6 kinase A4 [ Homo sapiens (human) ]

Gene ID: 8986, updated on 25-Nov-2021

Summary

Official Symbol
RPS6KA4provided by HGNC
Official Full Name
ribosomal protein S6 kinase A4provided by HGNC
Primary source
HGNC:HGNC:10433
See related
Ensembl:ENSG00000162302 MIM:603606
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSK2; RSK-B; S6K-alpha-4
Summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in spleen (RPKM 12.2), colon (RPKM 9.2) and 25 other tissues See more
Orthologs
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Genomic context

See RPS6KA4 in Genome Data Viewer
Location:
11q13.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (64359162..64372215)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64126634..64139687)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723878 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3041 Neighboring gene coiled-coil domain containing 88B Neighboring gene microRNA 7155 Neighboring gene microRNA 1237 Neighboring gene long intergenic non-protein coding RNA 2723 Neighboring gene uncharacterized LOC105369341

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ribosomal protein S6 kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in histone H3-S10 phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone H3-S28 phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cytokine production TAS
Traceable Author Statement
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of CREB transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of histone acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of histone phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribosomal protein S6 kinase alpha-4
Names
90 kDa ribosomal protein S6 kinase 4
mitogen- and stress-activated protein kinase 2
nuclear mitogen- and stress-activated protein kinase 2
ribosomal protein S6 kinase, 90kDa, polypeptide 4
ribosomal protein kinase B
NP_001006945.1
NP_001287731.1
NP_001305290.1
NP_003933.1
XP_005274437.1
XP_016874016.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006944.2NP_001006945.1  ribosomal protein S6 kinase alpha-4 isoform b

    See identical proteins and their annotated locations for NP_001006945.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform b).
    Source sequence(s)
    AF074715, AJ010119, BI523588
    UniProtKB/Swiss-Prot
    O75676
    Related
    ENSP00000432945.1, ENST00000530504.1
    Conserved Domains (3) summary
    smart00220
    Location:33301
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05614
    Location:32364
    STKc_MSK2_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2
    cl21453
    Location:400708
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001300802.2NP_001287731.1  ribosomal protein S6 kinase alpha-4 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform c).
    Source sequence(s)
    AJ010119, AK223561, AK313567, AP003774
    Consensus CDS
    CCDS73313.1
    UniProtKB/Swiss-Prot
    O75676
    UniProtKB/TrEMBL
    E9PJN1
    Related
    ENSP00000435580.1, ENST00000528057.5
    Conserved Domains (3) summary
    smart00220
    Location:33301
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05614
    Location:32364
    STKc_MSK2_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2
    cl21453
    Location:400707
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001318361.2NP_001305290.1  ribosomal protein S6 kinase alpha-4 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AJ010119, AK298507, AP003774, BI253655
    UniProtKB/Swiss-Prot
    O75676
    UniProtKB/TrEMBL
    B4DPV1
    Conserved Domains (2) summary
    smart00220
    Location:354611
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1301
    PKc_like; Protein Kinases, catalytic domain
  4. NM_003942.3NP_003933.1  ribosomal protein S6 kinase alpha-4 isoform a

    See identical proteins and their annotated locations for NP_003933.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AJ010119, BC028079, BI523588
    Consensus CDS
    CCDS8073.1
    UniProtKB/Swiss-Prot
    O75676
    UniProtKB/TrEMBL
    A0PJF8
    Related
    ENSP00000333896.4, ENST00000334205.9
    Conserved Domains (3) summary
    smart00220
    Location:33301
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05614
    Location:32364
    STKc_MSK2_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2
    cl21453
    Location:404714
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    64359162..64372215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274380.1XP_005274437.1  ribosomal protein S6 kinase alpha-4 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:32308
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017018527.2XP_016874016.1  ribosomal protein S6 kinase alpha-4 isoform X2

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