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SIGLEC12 sialic acid binding Ig like lectin 12 [ Homo sapiens (human) ]

Gene ID: 89858, updated on 25-Jan-2022

Summary

Official Symbol
SIGLEC12provided by HGNC
Official Full Name
sialic acid binding Ig like lectin 12provided by HGNC
Primary source
HGNC:HGNC:15482
See related
Ensembl:ENSG00000254521 MIM:606094; AllianceGenome:HGNC:15482
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S2V; SLG; SIGLECL1; Siglec-XII
Summary
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Biased expression in spleen (RPKM 5.4), appendix (RPKM 3.1) and 9 other tissues See more
Orthologs
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Genomic context

See SIGLEC12 in Genome Data Viewer
Location:
19q13.41
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (51491227..51501800, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51994481..52005054, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sialic acid binding Ig like lectin 25, pseudogene Neighboring gene sialic acid binding Ig like lectin 26, pseudogene Neighboring gene CEA cell adhesion molecule 18 Neighboring gene sialic acid binding Ig like lectin 27, pseudogene Neighboring gene sialic acid binding Ig like lectin 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38600

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sialic acid-binding Ig-like lectin 12
Names
SIGLEC-like 1
sialic acid-binding Ig-like lectin-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033329.2NP_201586.1  sialic acid-binding Ig-like lectin 12 isoform b precursor

    See identical proteins and their annotated locations for NP_201586.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as SLG-Short (SLG-S), differs in the 5' UTR and uses an alternate segment in the 5' coding region compared to variant 1, resulting in the use of an alternate in-frame translation initiation codon. It encodes an isoform (b) with a different and shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC020914
    Consensus CDS
    CCDS59416.1
    UniProtKB/Swiss-Prot
    Q96PQ1
    Related
    ENSP00000472873.1, ENST00000598614.1
    Conserved Domains (2) summary
    smart00410
    Location:271344
    IG_like; Immunoglobulin like
    cl11960
    Location:33151
    Ig; Immunoglobulin domain
  2. NM_053003.4NP_443729.1  sialic acid-binding Ig-like lectin 12 isoform a precursor

    See identical proteins and their annotated locations for NP_443729.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as SLG-Long (SLG-L), encodes the longer isoform (a). Unlike other members of the SIGLEC3-like subfamily, which contain only one V-set immunoglobin-like domain, isoform a contains two.
    Source sequence(s)
    AC020914, AY358140, BC035809, DA562082
    Consensus CDS
    CCDS12833.1
    UniProtKB/Swiss-Prot
    Q96PQ1
    Related
    ENSP00000291707.3, ENST00000291707.8
    Conserved Domains (2) summary
    smart00410
    Location:389462
    IG_like; Immunoglobulin like
    cl11960
    Location:24142
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    51491227..51501800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527441.2XP_011525743.1  sialic acid-binding Ig-like lectin 12 isoform X1

    See identical proteins and their annotated locations for XP_011525743.1

    UniProtKB/Swiss-Prot
    Q96PQ1
    Conserved Domains (2) summary
    smart00410
    Location:271344
    IG_like; Immunoglobulin like
    cl11960
    Location:33151
    Ig; Immunoglobulin domain
  2. XM_011527442.2XP_011525744.1  sialic acid-binding Ig-like lectin 12 isoform X2

    Conserved Domains (2) summary
    smart00410
    Location:389462
    IG_like; Immunoglobulin like
    cl11960
    Location:24142
    Ig; Immunoglobulin domain
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