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PLOD3 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 [ Homo sapiens (human) ]

Gene ID: 8985, updated on 6-Jul-2025
Official Symbol
PLOD3provided by HGNC
Official Full Name
procollagen-lysine,2-oxoglutarate 5-dioxygenase 3provided by HGNC
Primary source
HGNC:HGNC:9083
See related
Ensembl:ENSG00000106397 MIM:603066; AllianceGenome:HGNC:9083
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LH3; BCARD
Summary
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 21.7), endometrium (RPKM 12.9) and 25 other tissues See more
Orthologs
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See PLOD3 in Genome Data Viewer
Location:
7q22.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (101205984..101217581, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (102529447..102541882, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100849265..100860862, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100845469-100846276 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100846277-100847083 Neighboring gene diacylglycerol O-acyltransferase 2 like 7, pseudogene Neighboring gene ribosomal protein SA pseudogene 46 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100859968-100860490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26401 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100861252-100861793 Neighboring gene zinc finger HIT-type containing 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:100870334-100870510 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100874831-100875752 Neighboring gene claudin 15

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding EXP
Inferred from Experiment
more info
PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding EXP
Inferred from Experiment
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
enables procollagen galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables procollagen galactosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables procollagen galactosyltransferase activity TAS
Traceable Author Statement
more info
 
enables procollagen glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables procollagen glucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables procollagen glucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables procollagen-lysine 5-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables procollagen-lysine 5-dioxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables procollagen-lysine 5-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables procollagen-lysine 5-dioxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small molecule binding EXP
Inferred from Experiment
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within basement membrane assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in collagen fibril organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within collagen fibril organization IEA
Inferred from Electronic Annotation
more info
 
involved_in collagen fibril organization TAS
Traceable Author Statement
more info
 
acts_upstream_of_or_within collagen metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endothelial cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within epidermis morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in hydroxylysine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural tube development IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-lysine hydroxylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-lysine hydroxylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within vasodilation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
Names
lysine hydroxylase 3
lysyl hydroxlase 3
lysyl hydroxylase 3
NP_001075.1
XP_054215277.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012148.1 RefSeqGene

    Range
    5150..16747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001084.5NP_001075.1  multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 precursor

    See identical proteins and their annotated locations for NP_001075.1

    Status: REVIEWED

    Source sequence(s)
    AC004876, AL049952, BC011674
    Consensus CDS
    CCDS5715.1
    UniProtKB/Swiss-Prot
    B2R6W6, O60568, Q540C3
    UniProtKB/TrEMBL
    B3KQQ3
    Related
    ENSP00000223127.3, ENST00000223127.8
    Conserved Domains (1) summary
    smart00702
    Location:573736
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    101205984..101217581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    102529447..102541882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359302.1XP_054215277.1  multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 isoform X1

    UniProtKB/Swiss-Prot
    B2R6W6, O60568, Q540C3
    UniProtKB/TrEMBL
    B3KQQ3