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ARHGAP11B Rho GTPase activating protein 11B [ Homo sapiens (human) ]

Gene ID: 89839, updated on 24-Nov-2020

Summary

Official Symbol
ARHGAP11Bprovided by HGNC
Official Full Name
Rho GTPase activating protein 11Bprovided by HGNC
Primary source
HGNC:HGNC:15782
See related
Ensembl:ENSG00000284906 MIM:616310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B'-T; FAM7B1; GAP (1-8)
Expression
Broad expression in bone marrow (RPKM 7.6), lymph node (RPKM 4.9) and 16 other tissues See more
Orthologs

Genomic context

See ARHGAP11B in Genome Data Viewer
Location:
15q13.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (30626128..30649229)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (30918879..30931013)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene 15q13.2-13.3 gamma inversion proximal recombination region Neighboring gene uncharacterized LOC102725021 Neighboring gene ULK4 pseudogene 2 Neighboring gene 15q13 proximal microdeletion recombination region Neighboring gene golgin A8 family member H Neighboring gene RNA, 7SL, cytoplasmic 628, pseudogene Neighboring gene nonconserved acetylation island sequence 49 enhancer Neighboring gene OTU deubiquitinase 7A pseudogene Neighboring gene proximal CHRNA7 low-copy repeat recombination region Neighboring gene golgin subfamily A member 8M-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104367

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cerebral cortex development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 11B
Names
family with sequence similarity 7, member B1
rho-type GTPase-activating protein 11B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039841.3NP_001034930.1  rho GTPase-activating protein 11B

    See identical proteins and their annotated locations for NP_001034930.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC091057, AL556699, BC105788
    Consensus CDS
    CCDS32185.1
    UniProtKB/Swiss-Prot
    Q3KRB8
    Related
    ENSP00000457054.1, ENST00000563110.6
    Conserved Domains (1) summary
    cd04394
    Location:46226
    RhoGAP-ARHGAP11A; RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing ...

RNA

  1. NR_148423.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC091057

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    30626128..30649229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_011332701.1 Reference GRCh38.p13 PATCHES

    Range
    2798623..2822311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_012132920.1 Reference GRCh38.p13 PATCHES

    Range
    1878743..1902434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187660.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    2911075..2934763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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