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Chl1 cell adhesion molecule L1-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 89828, updated on 18-Apr-2019

Summary

Official Symbol
Chl1provided by RGD
Official Full Name
cell adhesion molecule L1-likeprovided by RGD
Primary source
RGD:620122
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Call
Summary
mouse homolog is a neuronal cell adhesion molecule involved in promoting elongation of neurites and survival of nerve cells [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 405.3), Testes (RPKM 284.7) and 1 other tissue See more
Orthologs

Genomic context

See Chl1 in Genome Data Viewer
Location:
4q23
Exon count:
21
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (70269414..70331313)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (134915211..135121060)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L30-like Neighboring gene uncharacterized LOC108350698 Neighboring gene 60S ribosomal protein L4-like Neighboring gene rCG28262-like Neighboring gene T-cell receptor beta chain V region PHDS203-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
protease binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
PubMed 
axon guidance ISO
Inferred from Sequence Orthology
more info
PubMed 
axon regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
axon regeneration NAS
Non-traceable Author Statement
more info
PubMed 
cognition ISO
Inferred from Sequence Orthology
more info
PubMed 
exploration behavior ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
neuron migration ISO
Inferred from Sequence Orthology
more info
PubMed 
neuron projection development ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
apical part of cell ISO
Inferred from Sequence Orthology
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
cell adhesion molecule L1-like; neural cell adhesion molecule L1-like protein
Names
cell adhesion molecule with homology to L1CAM (close homologue of L1)

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    70269414..70331313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593078.1XP_017448567.1  neural cell adhesion molecule L1-like protein isoform X1

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    125052335..125267922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006224999.3XP_006225061.1  neural cell adhesion molecule L1-like protein isoform X2

    See identical proteins and their annotated locations for XP_006225061.1

    Conserved Domains (7) summary
    cd04978
    Location:360434
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05845
    Location:128222
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:263342
    IG_like; Immunoglobulin like
    cd00063
    Location:627716
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:730811
    fn3; Fibronectin type III domain
    pfam13882
    Location:11201205
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:273343
    Ig; Immunoglobulin domain
  2. XM_006225000.3XP_006225062.1  neural cell adhesion molecule L1-like protein isoform X2

    See identical proteins and their annotated locations for XP_006225062.1

    Conserved Domains (7) summary
    cd04978
    Location:360434
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05845
    Location:128222
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:263342
    IG_like; Immunoglobulin like
    cd00063
    Location:627716
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:730811
    fn3; Fibronectin type III domain
    pfam13882
    Location:11201205
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:273343
    Ig; Immunoglobulin domain
  3. XM_008775801.2XP_008774023.1  neural cell adhesion molecule L1-like protein isoform X4

    Conserved Domains (7) summary
    cd04978
    Location:360434
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05845
    Location:128222
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:263342
    IG_like; Immunoglobulin like
    cd00063
    Location:627716
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:730811
    fn3; Fibronectin type III domain
    pfam13882
    Location:10661151
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:273343
    Ig; Immunoglobulin domain
  4. XM_008775800.2XP_008774022.1  neural cell adhesion molecule L1-like protein isoform X3

    Conserved Domains (7) summary
    cd04978
    Location:344418
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05845
    Location:128222
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:247326
    IG_like; Immunoglobulin like
    cd00063
    Location:611700
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:714795
    fn3; Fibronectin type III domain
    pfam13882
    Location:11041189
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:257327
    Ig; Immunoglobulin domain
  5. XM_006225001.3XP_006225063.1  neural cell adhesion molecule L1-like protein isoform X2

    See identical proteins and their annotated locations for XP_006225063.1

    Conserved Domains (7) summary
    cd04978
    Location:360434
    Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
    cd05845
    Location:128222
    Ig2_L1-CAM_like; Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00410
    Location:263342
    IG_like; Immunoglobulin like
    cd00063
    Location:627716
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:730811
    fn3; Fibronectin type III domain
    pfam13882
    Location:11201205
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:273343
    Ig; Immunoglobulin domain
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