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KCNK17 potassium two pore domain channel subfamily K member 17 [ Homo sapiens (human) ]

Gene ID: 89822, updated on 23-Nov-2021

Summary

Official Symbol
KCNK17provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 17provided by HGNC
Primary source
HGNC:HGNC:14465
See related
Ensembl:ENSG00000124780 MIM:607370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TALK2; TASK4; TALK-2; TASK-4; K2p17.1
Summary
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Expression
Broad expression in lung (RPKM 2.2), stomach (RPKM 1.6) and 18 other tissues See more
Orthologs
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Genomic context

See KCNK17 in Genome Data Viewer
Location:
6p21.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (39299001..39314419, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (39266777..39282195, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 18E, pseudogene Neighboring gene SAYSVFN motif domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 4644 Neighboring gene potassium two pore domain channel subfamily K member 5 Neighboring gene uncharacterized LOC105375047 Neighboring gene uncharacterized LOC107986594 Neighboring gene ankyrin repeat domain 39 pseudogene Neighboring gene potassium two pore domain channel subfamily K member 16 Neighboring gene kinesin family member 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Discovery and refinement of loci associated with lipid levels.
GeneReviews: Not available
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
GeneReviews: Not available
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
potassium channel subfamily K member 17
Names
2P domain potassium channel Talk-2
TWIK-related acid-sensitive K(+) channel 4
TWIK-related acid-sensitive K+ 4
TWIK-related alkaline pH-activated K(+) channel 2
acid-sensitive potassium channel protein TASK-4
potassium channel, two pore domain subfamily K, member 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047208.1 RefSeqGene

    Range
    5043..20461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135111.2NP_001128583.1  potassium channel subfamily K member 17 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional exon at the 3' end compared to transcript variant 1. This results in a frame-shift and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL136087, BC025726
    Consensus CDS
    CCDS47419.1
    UniProtKB/Swiss-Prot
    Q96T54
    Related
    ENSP00000401271.2, ENST00000453413.2
    Conserved Domains (1) summary
    pfam07885
    Location:96157
    Ion_trans_2; Ion channel
  2. NM_031460.4NP_113648.2  potassium channel subfamily K member 17 isoform 1

    See identical proteins and their annotated locations for NP_113648.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF358910, BC025726, BP317866
    Consensus CDS
    CCDS4842.1
    UniProtKB/Swiss-Prot
    Q96T54
    Related
    ENSP00000362328.4, ENST00000373231.9
    Conserved Domains (1) summary
    pfam07885
    Location:96157
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    39299001..39314419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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