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Angpt1 angiopoietin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 89807, updated on 6-May-2021

Summary

Official Symbol
Angpt1provided by RGD
Official Full Name
angiopoietin 1provided by RGD
Primary source
RGD:628896
See related
Ensembl:ENSRNOG00000005854
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Agpt; Agpt1; Ang-1
Summary
modulates endothelial cell survival and involved in the activation of endothelial cell-specific Tie-2 receptors [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 122.6), Heart (RPKM 89.2) and 8 other tissues See more
Orthologs
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Genomic context

See Angpt1 in Genome Data Viewer
Location:
7q31
Exon count:
9
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (73528345..73783953, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (81338327..81592459, complement)

Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene cell division cycle 26-like Neighboring gene similar to keratin complex 1, acidic, gene 18 Neighboring gene uncharacterized LOC102547184 Neighboring gene uncharacterized LOC102547251 Neighboring gene uncharacterized LOC120093647 Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Tie signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Tie signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Tie signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in glomerulus vasculature development IEA
Inferred from Electronic Annotation
more info
 
involved_in glomerulus vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glomerulus vasculature development ISO
Inferred from Sequence Orthology
more info
 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
involved_in heparin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in heparin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in liver regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytokine production involved in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood-brain barrier permeability IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of blood-brain barrier permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor internalization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of macrophage migration inhibitory factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of macrophage migration inhibitory factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of skeletal muscle satellite cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of skeletal muscle satellite cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin B3 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within transmembrane receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053546.2NP_445998.2  angiopoietin-1 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000185
    Related
    ENSRNOP00000007979.5, ENSRNOT00000007979.6
    Conserved Domains (2) summary
    COG1196
    Location:55279
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00087
    Location:280495
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

    Range
    73528345..73783953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241609.4XP_006241671.1  angiopoietin-1 isoform X1

    Conserved Domains (2) summary
    COG4372
    Location:55255
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd00087
    Location:281496
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
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