Tek TEK receptor tyrosine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tekprovided by RGD
Official Full Name: TEK receptor tyrosine kinaseprovided by RGD
Primary source: RGD:620980
See related: Ensembl:ENSRNOG00000008587 AllianceGenome:RGD:620980
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tie2; Tie-2
Summary: Enables growth factor binding activity. Involved in several processes, including endochondral ossification; response to cAMP; and response to estrogen. Predicted to be located in several cellular components, including basolateral plasma membrane; centriolar satellite; and microvillus. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Predicted to colocalize with actin filament and stress fiber. Biomarker of several diseases, including acute kidney tubular necrosis; brain ischemia; gastric ulcer; goiter; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in arteriovenous malformation and multiple cutaneous and mucosal venous malformations. Orthologous to human TEK (TEK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 772.5), Heart (RPKM 237.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (114722815..114849535)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (109607077..109733805)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (113725717..113852799)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[A low androgen state impairs erectile function by suppressing the expression of Tie2 in rat penile cavernosa].
Title: [A low androgen state impairs erectile function by suppressing the expression of Tie2 in rat penile cavernosa].
Results demonstrated that thrombin promotes pericyte coverage on microvessels following ICH by enhancing activation of Tie2, in which the downstream PI3K/Akt signaling pathway might be involved.
Title: Thrombin promotes pericyte coverage by Tie2 activation in a rat model of intracerebral hemorrhage.
These findings suggested that miR-150 could regulate claudin-5 expression and endothelial cell survival by targeting Tie-2, thus affecting the permeability of BBB after permanent middle cerebral artery occlusion in rats, and that miR-150 might be a potential alternative target for the treatment of stroke.
Title: MicroRNA-150 regulates blood-brain barrier permeability via Tie-2 after permanent middle cerebral artery occlusion in rats.
Hypoxia significantly increased protein levels of VEGF, KDR, Angiopoiein 1, and Tie2, which were reduced following Compound 49b treatment. These data strongly suggested that Compound 49b protected the retina against I/R-induced injury. This provides additional support for a role of beta-adrenergic receptor actions in the retina.
Title: Compound 49b Restores Retinal Thickness and Reduces Degenerate Capillaries in the Rat Retina following Ischemia/Reperfusion.
Tie2 extracellular domain initially inhibited angiogenesis, and its degradation relieved inhibition of new vessel formation
Title: Temporal expression in rats of receptor tyrosine kinase Tie2 during early wound healing after tooth extraction.
COMP-Ang1-stimulated proliferation, differentiation, and migration of progenitor cells may involve the Tie-2-mediated activation of p38 MAPK and PI3K/Akt pathways
Title: COMP-angiopoietin 1 increases proliferation, differentiation, and migration of stem-like cells through Tie-2-mediated activation of p38 MAPK and PI3K/Akt signal transduction pathways.
Tie2-dependent neovascularization of the ischemic hindlimb is mediated by angiopoietin-2.
Title: Tie2-dependent neovascularization of the ischemic hindlimb is mediated by angiopoietin-2.
expression and tyrosine phosphorylation of Tie2 in superior mesenteric arteries gradually increased after hemorrhagic shock
Title: Angiopoietins regulate vascular reactivity after haemorrhagic shock in rats through the Tie2-nitric oxide pathway.
Angiopoietins/TIE2 system and VEGF are involved in ovarian function in a DHEA rat model of polycystic ovary syndrome
Title: Angiopoietins/TIE2 system and VEGF are involved in ovarian function in a DHEA rat model of polycystic ovary syndrome.
Enhanced expression of Ang-1 and Tie-2 by exercise improves recovery of brain function in middle cerebral artery occluded rats.
Title: Exercise improves recovery after ischemic brain injury by inducing the expression of angiopoietin-1 and Tie-2 in rats.

Submit: New GeneRIF Correction See all GeneRIFs (27)

General gene information

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Markers

Tek (e-PCR), detects polymorphism
- UniSTS:463377

Tek (e-PCR), detects polymorphism
- UniSTS:498487

RH137123 (e-PCR)
- UniSTS:219211

D5Lev12 (e-PCR)
- UniSTS:239708

D5Uwm29 (e-PCR)
- UniSTS:239983

RH138516 (e-PCR)
- UniSTS:220603

Tek (e-PCR), detects polymorphism
- UniSTS:144601

RH138553 (e-PCR)
- UniSTS:220640

Tek (e-PCR), detects polymorphism
- UniSTS:275691

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Tie signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Tie signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in endochondral ossification	IEP Inferred from Expression Pattern more info	PubMed
involved_in endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in glomerulus vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in heart trabecula formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_positive_effect positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment or maintenance of cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to organic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: angiopoietin-1 receptor

Names: TEK tyrosine kinase, endothelial; endothelial-specific receptor tyrosine kinase; tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2

NP_001099207.1

EC 2.7.10.1

XP_038966820.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105737.1 → NP_001099207.1 angiopoietin-1 receptor

See identical proteins and their annotated locations for NP_001099207.1

Status: PROVISIONAL

Source sequence(s)

CH473998

UniProtKB/TrEMBL

A0A8I5ZW61, A6JRG8, D3ZCD0

Related

ENSRNOP00000036086.3, ENSRNOT00000032248.4

Conserved Domains (6) summary

cd05088
Location:812 → 1114

PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2

smart00221
Location:820 → 1088

STYKc; Protein kinase; unclassified specificity

cd00055
Location:230 → 275

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00063
Location:638 → 730

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:542 → 625

fn3; Fibronectin type III domain

pfam10430
Location:24 → 118

Ig_Tie2_1; Tie-2 Ig-like domain 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

114722815..114849535

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110892.2 → XP_038966820.1 angiopoietin-1 receptor isoform X1

Conserved Domains (4) summary

cd05088
Location:586 → 888

PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2

cd00063
Location:412 → 504

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:316 → 399

fn3; Fibronectin type III domain

cd20964
Location:122 → 213

IgI_Tie2; Immunoglobulin domain of Tie2 tyrosine kinase; a member of the I-set of IgSF domains