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PPP1R3F protein phosphatase 1 regulatory subunit 3F [ Homo sapiens (human) ]

Gene ID: 89801, updated on 4-May-2020

Summary

Official Symbol
PPP1R3Fprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 3Fprovided by HGNC
Primary source
HGNC:HGNC:14944
See related
Ensembl:ENSG00000049769
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
R3F; HB2E; LL0XNC01-7P3.1
Summary
This gene encodes a protein that has been identified as one of several type-1 protein phosphatase (PP1) regulatory subunits. One or two of these subunits, together with the well-conserved catalytic subunit, can form the PP1 holoenzyme, where the regulatory subunit functions to regulate substrate specificity and/or targeting to a particular cellular compartment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Expression
Broad expression in brain (RPKM 2.6), heart (RPKM 1.4) and 23 other tissues See more
Orthologs

Genomic context

See PPP1R3F in Genome Data Viewer
Location:
Xp11.23
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (49269793..49301465)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (49126305..49144557)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 22 Neighboring gene forkhead box P3 Neighboring gene FOXP3 regulating long intergenic non-coding RNA Neighboring gene G antigen 10 Neighboring gene G antigen 12J

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glycogen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycogen binding IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of glycogen (starch) synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of glycogen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 3F
Names
protein phosphatase 1, regulatory (inhibitor) subunit 3F

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021273.1 RefSeqGene

    Range
    4951..23247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184745.2NP_001171674.1  protein phosphatase 1 regulatory subunit 3F isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' coding region, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an internal residue, compared to isoform 1.
    Source sequence(s)
    AC232271, AI694535, AI699647, BC110405, BC131588, BE670223, DC412626
    Consensus CDS
    CCDS55415.1
    UniProtKB/Swiss-Prot
    Q6ZSY5
    UniProtKB/TrEMBL
    Q0D2I0
    Related
    ENSP00000417535.1, ENST00000495799.5
  2. NM_033215.5NP_149992.3  protein phosphatase 1 regulatory subunit 3F isoform 1

    See identical proteins and their annotated locations for NP_149992.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC232271, AI694535, AI699647, AK056909, BE670223, BF726691, DC412626
    Consensus CDS
    CCDS35254.1
    UniProtKB/Swiss-Prot
    Q6ZSY5
    Related
    ENSP00000055335.6, ENST00000055335.11
    Conserved Domains (1) summary
    pfam03370
    Location:163283
    CBM_21; Carbohydrate/starch-binding module (family 21)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    49269793..49301465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029934.1XP_016885423.1  protein phosphatase 1 regulatory subunit 3F isoform X4

  2. XM_005272687.3XP_005272744.1  protein phosphatase 1 regulatory subunit 3F isoform X1

    Conserved Domains (1) summary
    pfam03370
    Location:163283
    CBM_21; Carbohydrate/starch-binding module (family 21)
  3. XM_017029933.1XP_016885422.1  protein phosphatase 1 regulatory subunit 3F isoform X3

  4. XM_017029932.1XP_016885421.1  protein phosphatase 1 regulatory subunit 3F isoform X2

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