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GAL3ST3 galactose-3-O-sulfotransferase 3 [ Homo sapiens (human) ]

Gene ID: 89792, updated on 23-Nov-2021

Summary

Official Symbol
GAL3ST3provided by HGNC
Official Full Name
galactose-3-O-sulfotransferase 3provided by HGNC
Primary source
HGNC:HGNC:24144
See related
Ensembl:ENSG00000175229 MIM:608234
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAL3ST2; GAL3ST-3
Summary
This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3. [provided by RefSeq, Jul 2008]
Expression
Biased expression in thyroid (RPKM 2.2), endometrium (RPKM 2.0) and 5 other tissues See more
Orthologs
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Genomic context

See GAL3ST3 in Genome Data Viewer
Location:
11q13.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (66040765..66049161, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65808236..65816632, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated 1 Neighboring gene cystatin E/M Neighboring gene small nucleolar RNA, C/D box 13F Neighboring gene splicing factor 3b subunit 2 Neighboring gene phosphofurin acidic cluster sorting protein 1 Neighboring gene uncharacterized LOC105369354

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
GeneReviews: Not available
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142112, MGC142114

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding NAS
Non-traceable Author Statement
more info
PubMed 
enables carbohydrate binding NAS
Non-traceable Author Statement
more info
PubMed 
enables galactose 3-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables galactose 3-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables galactose 3-O-sulfotransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables galactosylceramide sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables proteoglycan sulfotransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
galactose-3-O-sulfotransferase 3
Names
beta-galactose-3-O-sulfotransferase 3
gal-beta-1, 3-GalNAc 3'-sulfotransferase 3
galactose 3'-sulfotransferase
galbeta1-3GalNAc 3'-sulfotransferase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033036.3NP_149025.1  galactose-3-O-sulfotransferase 3

    See identical proteins and their annotated locations for NP_149025.1

    Status: REVIEWED

    Source sequence(s)
    AB053232, AP006287, BM673570
    Consensus CDS
    CCDS8128.1
    UniProtKB/Swiss-Prot
    Q96A11
    Related
    ENSP00000308591.3, ENST00000312006.5
    Conserved Domains (1) summary
    pfam06990
    Location:1399
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    66040765..66049161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018519.1XP_016874008.1  galactose-3-O-sulfotransferase 3 isoform X1

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