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SIGLEC10 sialic acid binding Ig like lectin 10 [ Homo sapiens (human) ]

Gene ID: 89790, updated on 5-Aug-2026
Official Symbol
SIGLEC10provided by HGNC
Official Full Name
sialic acid binding Ig like lectin 10provided by HGNC
Primary source
HGNC:HGNC:15620
See related
Ensembl:ENSG00000142512 MIM:606091; AllianceGenome:HGNC:15620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLG2; PRO940; SIGLEC-10
Summary
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]
Expression
Biased expression in appendix (RPKM 14.2), spleen (RPKM 13.0) and 12 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See SIGLEC10 in Genome Data Viewer
Location:
19q13.41
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51410020..51417642, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54498651..54506273, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51913274..51920896, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene chromosome 19 open reading frame 84 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:51897116-51897712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15015 Neighboring gene NIFK pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51912204-51912704 Neighboring gene SIGLEC10 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15018 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51941886-51942056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15020 Neighboring gene sialic acid binding Ig like lectin 8 Neighboring gene sialic acid binding Ig like lectin 25, pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Identification of Siglec-10 as a new dendritic cell checkpoint for cervical cancer immunotherapy. Wang C, et al. J Immunother Cancer, 2024 Aug 28. PMID 39209455, Free PMC Article
  2. Pseudaminic acid on Campylobacter jejuni flagella modulates dendritic cell IL-10 expression via Siglec-10 receptor: a novel flagellin-host interaction. Stephenson HN, et al. J Infect Dis, 2014 Nov 1. PMID 24823621, Free PMC Article
  3. Siglec10 Expression on Tumor-associated Macrophages Is an Independent Prognostic Factor in Stage I Lung Adenocarcinoma. Yoshida C, et al. Anticancer Res, 2024 Mar. PMID 38423652
  4. SIGLEC10(+) macrophages drive gastric cancer progression by suppressing CD8(+) T cell function. Guo Y, et al. Cancer Immunol Immunother, 2023 Oct. PMID 37432407, Free PMC Article
  5. Long-Term Elevated Siglec-10 in Cerebral Spinal Fluid Heralds Better Prognosis for Patients with Aneurysmal Subarachnoid Hemorrhage. Gao S, et al. Dis Markers, 2022. PMID 36188429, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of Siglec-10 as a new dendritic cell checkpoint for cervical cancer immunotherapy.
    Title: Identification of Siglec-10 as a new dendritic cell checkpoint for cervical cancer immunotherapy.
  2. Siglec10 Expression on Tumor-associated Macrophages Is an Independent Prognostic Factor in Stage I Lung Adenocarcinoma.
    Title: Siglec10 Expression on Tumor-associated Macrophages Is an Independent Prognostic Factor in Stage I Lung Adenocarcinoma.
  3. Gene expression patterns of CRYM and SIGLEC10 in Alzheimer's disease: potential early diagnostic indicators.
    Title: Gene expression patterns of CRYM and SIGLEC10 in Alzheimer's disease: potential early diagnostic indicators.
  4. High Expression and Significance of Siglec10/CD24 in Unexplained Missed Abortion.
    Title: High Expression and Significance of Siglec10/CD24 in Unexplained Missed Abortion.
  5. Long-Term Elevated Siglec-10 in Cerebral Spinal Fluid Heralds Better Prognosis for Patients with Aneurysmal Subarachnoid Hemorrhage.
    Title: Long-Term Elevated Siglec-10 in Cerebral Spinal Fluid Heralds Better Prognosis for Patients with Aneurysmal Subarachnoid Hemorrhage.
  6. Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples.
    Title: Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples.
  7. A Guillain-Barre syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides.
    Title: A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides.
  8. Novel insights into the function of CD24: A driving force in cancer.
    Title: Novel insights into the function of CD24: A driving force in cancer.
  9. Molecular Mechanism of Tumor Cell Immune Escape Mediated by CD24/Siglec-10.
    Title: Molecular Mechanism of Tumor Cell Immune Escape Mediated by CD24/Siglec-10.
  10. Siglec-10 expression is up-regulated in activated human CD4(+) T cells.
    Title: Siglec-10 expression is up-regulated in activated human CD4(+) T cells.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC126774

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH2 domain binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of inflammatory response to wounding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
sialic acid-binding Ig-like lectin 10
Names
sialic acid binding Ig-like lectin 10 Ig-like lectin 7
siglec-like gene 2
siglec-like protein 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171156.2 → NP_001164627.1  sialic acid-binding Ig-like lectin 10 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001164627.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS54303.1
    UniProtKB/TrEMBL
    B7ZL06
    Related
    ENSP00000389132.2, ENST00000439889.7
    Conserved Domains (4) summary
    cd00096
    Location:320 → 381
    Ig; Immunoglobulin domain
    smart00408
    Location:211 → 272
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:309 → 384
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 140
    Ig; Immunoglobulin domain

  2. NM_001171157.2 → NP_001164628.1  sialic acid-binding Ig-like lectin 10 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001164628.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS54305.1
    UniProtKB/TrEMBL
    B7ZL04
    Related
    ENSP00000342389.5, ENST00000353836.10
    Conserved Domains (3) summary
    cd00096
    Location:146 → 150
    Ig; Ig strand A [structural motif]
    cd05712
    Location:21 → 140
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cl11960
    Location:146 → 233
    Ig; Immunoglobulin domain

  3. NM_001171158.2 → NP_001164629.1  sialic acid-binding Ig-like lectin 10 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame segment and an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (4) lacks two internal segments, as compared to isoform 1.
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS54304.1
    UniProtKB/TrEMBL
    B7ZL04
    Related
    ENSP00000414324.2, ENST00000436984.7
    Conserved Domains (4) summary
    cd00096
    Location:330 → 391
    Ig; Immunoglobulin domain
    smart00408
    Location:221 → 282
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:319 → 394
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 140
    Ig; Immunoglobulin domain

  4. NM_001171159.2 → NP_001164630.1  sialic acid-binding Ig-like lectin 10 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001164630.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame segment and an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (5) lacks two internal segments, as compared to isoform 1.
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS54302.1
    UniProtKB/TrEMBL
    B7ZL04
    Related
    ENSP00000408387.2, ENST00000441969.8
    Conserved Domains (4) summary
    cd00096
    Location:320 → 381
    Ig; Immunoglobulin domain
    smart00408
    Location:211 → 272
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:309 → 384
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 140
    Ig; Immunoglobulin domain

  5. NM_001171161.2 → NP_001164632.1  sialic acid-binding Ig-like lectin 10 isoform 7 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an in-frame segment and two in-frame exons in the CDS, as compared to variant 1. The resulting isoform (7) lacks three internal segments, as compared to isoform 1.
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS54301.1
    UniProtKB/TrEMBL
    A0ACI8VB05
    Related
    ENSP00000395475.2, ENST00000442846.7
    Conserved Domains (3) summary
    cd00096
    Location:230 → 291
    Ig; Immunoglobulin domain
    smart00410
    Location:219 → 294
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 140
    Ig; Immunoglobulin domain

  6. NM_001322105.2 → NP_001309034.1  sialic acid-binding Ig-like lectin 10 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS82384.1
    UniProtKB/TrEMBL
    A0ACI8VB05, E9PL79
    Related
    ENSP00000431444.1, ENST00000525998.6
    Conserved Domains (3) summary
    cd00096
    Location:288 → 349
    Ig; Immunoglobulin domain
    smart00410
    Location:277 → 352
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 140
    Ig; Immunoglobulin domain

  7. NM_033130.5 → NP_149121.2  sialic acid-binding Ig-like lectin 10 isoform 1 precursor

    See identical proteins and their annotated locations for NP_149121.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS12832.1
    UniProtKB/Swiss-Prot
    A8K1I5, A8K3C7, C9JJ33, C9JM10, F8W917, Q3MIR5, Q6UXI8, Q96G54, Q96LC7, Q96LC8
    UniProtKB/TrEMBL
    B7ZL06
    Related
    ENSP00000345243.4, ENST00000339313.10
    Conserved Domains (4) summary
    cd00096
    Location:378 → 439
    Ig; Immunoglobulin domain
    smart00408
    Location:269 → 330
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:367 → 442
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 140
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51410020..51417642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439605.1 → XP_047295561.1  sialic acid-binding Ig-like lectin 10 isoform X6

    UniProtKB/TrEMBL
    B7ZL04

  2. XM_047439602.1 → XP_047295558.1  sialic acid-binding Ig-like lectin 10 isoform X3

    UniProtKB/TrEMBL
    B7ZL06

  3. XM_047439601.1 → XP_047295557.1  sialic acid-binding Ig-like lectin 10 isoform X2

    UniProtKB/TrEMBL
    B7ZL06

  4. XM_047439603.1 → XP_047295559.1  sialic acid-binding Ig-like lectin 10 isoform X4

    UniProtKB/TrEMBL
    B7ZL04

  5. XM_047439600.1 → XP_047295556.1  sialic acid-binding Ig-like lectin 10 isoform X1

    UniProtKB/TrEMBL
    B7ZL06
    Related
    ENST00000357375.4

  6. XM_005259367.5 → XP_005259424.1  sialic acid-binding Ig-like lectin 10 isoform X8

    UniProtKB/TrEMBL
    B7ZL06
    Conserved Domains (3) summary
    cd00096
    Location:230 → 291
    Ig; Immunoglobulin domain
    smart00410
    Location:219 → 294
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 140
    Ig; Immunoglobulin domain

  7. XM_047439604.1 → XP_047295560.1  sialic acid-binding Ig-like lectin 10 isoform X5

    UniProtKB/TrEMBL
    A0ACI8VAW7, B7ZL06
    Related
    ENSP00000631867.1, ENST00000961808.2

  8. XM_005259366.6 → XP_005259423.1  sialic acid-binding Ig-like lectin 10 isoform X7

    UniProtKB/TrEMBL
    A0ACI8VAX9, B7ZL06
    Related
    ENSP00000631866.1, ENST00000961807.2
    Conserved Domains (3) summary
    cd00096
    Location:288 → 349
    Ig; Immunoglobulin domain
    smart00410
    Location:277 → 352
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 140
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54498651..54506273 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322496.1 → XP_054178471.1  sialic acid-binding Ig-like lectin 10 isoform X8

    UniProtKB/TrEMBL
    B7ZL06

  2. XM_054322494.1 → XP_054178469.1  sialic acid-binding Ig-like lectin 10 isoform X5

    UniProtKB/TrEMBL
    A0ACI8VAW7, B7ZL06

  3. XM_054322495.1 → XP_054178470.1  sialic acid-binding Ig-like lectin 10 isoform X7

    UniProtKB/TrEMBL
    A0ACI8VAX9, B7ZL06

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001171160.1: Suppressed sequence

    Description
    NM_001171160.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96LC7.3 GenPept UniProtKB/Swiss-Prot:Q96LC7

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