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SIGLEC10 sialic acid binding Ig like lectin 10 [ Homo sapiens (human) ]

Gene ID: 89790, updated on 25-Jan-2022

Summary

Official Symbol
SIGLEC10provided by HGNC
Official Full Name
sialic acid binding Ig like lectin 10provided by HGNC
Primary source
HGNC:HGNC:15620
See related
Ensembl:ENSG00000142512 MIM:606091; AllianceGenome:HGNC:15620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLG2; PRO940; SIGLEC-10
Summary
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]
Expression
Biased expression in appendix (RPKM 14.2), spleen (RPKM 13.0) and 12 other tissues See more
Orthologs
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Genomic context

See SIGLEC10 in Genome Data Viewer
Location:
19q13.41
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (51410020..51417642, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51913274..51920896, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene LIM2 and SIGLEC10 antisense RNA 1 Neighboring gene chromosome 19 open reading frame 84 Neighboring gene nucleolar protein interacting with the FHA domain of MKI67 pseudogene 6 Neighboring gene SIGLEC10 antisense RNA 1 Neighboring gene sialic acid binding Ig like lectin 8 Neighboring gene sialic acid binding Ig like lectin 25, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126774

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH2 domain binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of inflammatory response to wounding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sialic acid-binding Ig-like lectin 10
Names
sialic acid binding Ig-like lectin 10 Ig-like lectin 7
siglec-like gene 2
siglec-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171156.2NP_001164627.1  sialic acid-binding Ig-like lectin 10 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001164627.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS54303.1
    UniProtKB/Swiss-Prot
    Q96LC7
    UniProtKB/TrEMBL
    B7ZL06
    Related
    ENSP00000389132.2, ENST00000439889.6
    Conserved Domains (4) summary
    cd00096
    Location:320381
    Ig; Immunoglobulin domain
    smart00408
    Location:211272
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:309384
    IG_like; Immunoglobulin like
    cl11960
    Location:23140
    Ig; Immunoglobulin domain
  2. NM_001171157.2NP_001164628.1  sialic acid-binding Ig-like lectin 10 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001164628.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS54305.1
    UniProtKB/Swiss-Prot
    Q96LC7
    Related
    ENSP00000342389.5, ENST00000353836.9
    Conserved Domains (3) summary
    cd00096
    Location:146150
    Ig; Ig strand A [structural motif]
    cd05712
    Location:21140
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cl11960
    Location:146233
    Ig; Immunoglobulin domain
  3. NM_001171158.2NP_001164629.1  sialic acid-binding Ig-like lectin 10 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame segment and an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (4) lacks two internal segments, as compared to isoform 1.
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS54304.1
    UniProtKB/Swiss-Prot
    Q96LC7
    Related
    ENSP00000414324.2, ENST00000436984.6
    Conserved Domains (4) summary
    cd00096
    Location:330391
    Ig; Immunoglobulin domain
    smart00408
    Location:221282
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:319394
    IG_like; Immunoglobulin like
    cl11960
    Location:23140
    Ig; Immunoglobulin domain
  4. NM_001171159.2NP_001164630.1  sialic acid-binding Ig-like lectin 10 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001164630.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame segment and an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (5) lacks two internal segments, as compared to isoform 1.
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS54302.1
    UniProtKB/Swiss-Prot
    Q96LC7
    UniProtKB/TrEMBL
    B7ZL06
    Related
    ENSP00000408387.2, ENST00000441969.7
    Conserved Domains (4) summary
    cd00096
    Location:320381
    Ig; Immunoglobulin domain
    smart00408
    Location:211272
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:309384
    IG_like; Immunoglobulin like
    cl11960
    Location:23140
    Ig; Immunoglobulin domain
  5. NM_001171161.2NP_001164632.1  sialic acid-binding Ig-like lectin 10 isoform 7 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an in-frame segment and two in-frame exons in the CDS, as compared to variant 1. The resulting isoform (7) lacks three internal segments, as compared to isoform 1.
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS54301.1
    UniProtKB/Swiss-Prot
    Q96LC7
    Related
    ENSP00000395475.2, ENST00000442846.7
    Conserved Domains (3) summary
    cd00096
    Location:230291
    Ig; Immunoglobulin domain
    smart00410
    Location:219294
    IG_like; Immunoglobulin like
    cl11960
    Location:23140
    Ig; Immunoglobulin domain
  6. NM_001322105.2NP_001309034.1  sialic acid-binding Ig-like lectin 10 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS82384.1
    UniProtKB/Swiss-Prot
    Q96LC7
    UniProtKB/TrEMBL
    E9PL79
    Related
    ENSP00000431444.1, ENST00000525998.5
    Conserved Domains (3) summary
    cd00096
    Location:288349
    Ig; Immunoglobulin domain
    smart00410
    Location:277352
    IG_like; Immunoglobulin like
    cl11960
    Location:23140
    Ig; Immunoglobulin domain
  7. NM_033130.5NP_149121.2  sialic acid-binding Ig-like lectin 10 isoform 1 precursor

    See identical proteins and their annotated locations for NP_149121.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS12832.1
    UniProtKB/Swiss-Prot
    Q96LC7
    Related
    ENSP00000345243.4, ENST00000339313.10
    Conserved Domains (4) summary
    cd00096
    Location:378439
    Ig; Immunoglobulin domain
    smart00408
    Location:269330
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:367442
    IG_like; Immunoglobulin like
    cl11960
    Location:23140
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    51410020..51417642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259366.5XP_005259423.1  sialic acid-binding Ig-like lectin 10 isoform X1

    Conserved Domains (3) summary
    cd00096
    Location:288349
    Ig; Immunoglobulin domain
    smart00410
    Location:277352
    IG_like; Immunoglobulin like
    cl11960
    Location:23140
    Ig; Immunoglobulin domain
  2. XM_005259367.4XP_005259424.1  sialic acid-binding Ig-like lectin 10 isoform X2

    Conserved Domains (3) summary
    cd00096
    Location:230291
    Ig; Immunoglobulin domain
    smart00410
    Location:219294
    IG_like; Immunoglobulin like
    cl11960
    Location:23140
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001171160.1: Suppressed sequence

    Description
    NM_001171160.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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