Format

Send to:

Choose Destination

LMLN leishmanolysin like peptidase [ Homo sapiens (human) ]

Gene ID: 89782, updated on 11-Sep-2019

Summary

Official Symbol
LMLNprovided by HGNC
Official Full Name
leishmanolysin like peptidaseprovided by HGNC
Primary source
HGNC:HGNC:15991
See related
Ensembl:ENSG00000185621 MIM:609380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INV; MSP; GP63; IX14; LMNL1
Summary
This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Expression
Broad expression in testis (RPKM 8.5), thyroid (RPKM 4.0) and 25 other tissues See more
Orthologs

Genomic context

See LMLN in Genome Data Viewer
Location:
3q29
Exon count:
17
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (197960200..198043720)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (197687071..197770591)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NUP98-IQCG recombination region Neighboring gene IQ motif containing G Neighboring gene ribosomal protein L35a Neighboring gene RNA, U6 small nuclear 621, pseudogene Neighboring gene LMLN antisense RNA 1 Neighboring gene ankyrin repeat domain 18D, pseudogene Neighboring gene RNA, U6 small nuclear 821, pseudogene Neighboring gene FSHD region gene 2 family member F, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
lipid droplet IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leishmanolysin-like peptidase
Names
invadolysin
leishmanolysin-2
leishmanolysin-like (metallopeptidase M8 family)
NP_001129521.2
NP_149018.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047207.1 RefSeqGene

    Range
    5001..88521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001136049.2NP_001129521.2  leishmanolysin-like peptidase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC135893, AJ312399, AK299119
    Consensus CDS
    CCDS46988.1
    UniProtKB/Swiss-Prot
    Q96KR4
    UniProtKB/TrEMBL
    B4DR62
    Related
    ENSP00000410926.2, ENST00000420910.6
    Conserved Domains (1) summary
    cl19482
    Location:107639
    Peptidase_M8; Leishmanolysin
  2. NM_033029.3NP_149018.2  leishmanolysin-like peptidase isoform 2

    See identical proteins and their annotated locations for NP_149018.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC135893, AJ312399, AK299119
    Consensus CDS
    CCDS3332.1
    UniProtKB/Swiss-Prot
    Q96KR4
    UniProtKB/TrEMBL
    B4DR62
    Related
    ENSP00000328829.4, ENST00000330198.8
    Conserved Domains (1) summary
    cl19482
    Location:107602
    Peptidase_M8; Leishmanolysin

RNA

  1. NR_026786.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, results in an upstream ORF that is predicted to interfere with translation of the longest ORF. This transcript is likely to be a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC135893, AJ312398, AK299119
  2. NR_026787.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' region and lacks an alternate exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, results in an upstream ORF that is predicted to interfere with translation of the longest ORF. This transcript is likely to be a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC135893, AJ312398, AK299119, AM920778

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    197960200..198043720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center