LMLN leishmanolysin like peptidase [Homo sapiens (human)] - Gene

Summary

Official Symbol: LMLNprovided by HGNC
Official Full Name: leishmanolysin like peptidaseprovided by HGNC
Primary source: HGNC:HGNC:15991
See related: Ensembl:ENSG00000185621 MIM:609380; AllianceGenome:HGNC:15991
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: INV; MSP; GP63; IX14; LMNL1
Summary: This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Expression: Broad expression in testis (RPKM 8.5), thyroid (RPKM 4.0) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 3q29

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (197960217..198043720)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (200692672..200776106)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (197687088..197770591)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-17-3p promotes the proliferation of multiple myeloma cells by downregulating P21 expression through LMLN inhibition.
Title: miR-17-3p promotes the proliferation of multiple myeloma cells by downregulating P21 expression through LMLN inhibition.
Immunofluorescent detection of human invadolysin in cultured cells reveals the protein to be associated with the surface of lipid droplets.
Title: The conserved metalloprotease invadolysin localizes to the surface of lipid droplets.
Functional characterization of a similar protein in Drosophila and comparative studies with the human protein.
Title: Invadolysin: a novel, conserved metalloprotease links mitotic structural rearrangements with cell migration.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-77716 (e-PCR)
- UniSTS:5954

G30979 (e-PCR)
- UniSTS:70805

G16589 (e-PCR)
- UniSTS:61641

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leishmanolysin-like peptidase

Names: invadolysin; leishmanolysin-2; leishmanolysin-like (metallopeptidase M8 family)

NP_001129521.3

EC 3.4.24.36

NP_149018.3

EC 3.4.24.36

XP_047305111.1

EC 3.4.24.36

XP_047305112.1

EC 3.4.24.36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047207.1 RefSeqGene

Range

5018..88521

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001136049.3 → NP_001129521.3 leishmanolysin-like peptidase isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC135893, AJ312399, AK299119

Consensus CDS

CCDS46988.2

UniProtKB/TrEMBL

B4DR62

Related

ENSP00000410926.3, ENST00000420910.7

Conserved Domains (1) summary

cl19482
Location:99 → 631

Peptidase_M8; Leishmanolysin
NM_033029.4 → NP_149018.3 leishmanolysin-like peptidase isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC135893, AJ312399, AK299119

Consensus CDS

CCDS3332.2

UniProtKB/Swiss-Prot

B3LDG9, B3LDH0, C9J796, F8WB28, Q96KR4, Q96KR5

Related

ENSP00000328829.5, ENST00000330198.8

Conserved Domains (1) summary

cl19482
Location:99 → 594

Peptidase_M8; Leishmanolysin

RNA

NR_026786.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, results in an upstream ORF that is predicted to interfere with translation of the longest ORF. This transcript is likely to be a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC135893, AJ312398, AK299119
NR_026787.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate splice site in the 5' region and lacks an alternate exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, results in an upstream ORF that is predicted to interfere with translation of the longest ORF. This transcript is likely to be a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC135893, AJ312398, AK299119, AM920778