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SERPINB11 serpin family B member 11 (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 89778, updated on 12-May-2019

Summary

Official Symbol
SERPINB11provided by HGNC
Official Full Name
serpin family B member 11 (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:14221
See related
Ensembl:ENSG00000206072 MIM:615682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPIPIN; SERPIN11
Expression
Biased expression in prostate (RPKM 17.6), esophagus (RPKM 11.7) and 1 other tissue See more
Orthologs

Genomic context

See SERPINB11 in Genome Data Viewer
Location:
18q21.33
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (63702304..63723893)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (61370194..61391123)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene serpin family B member 4 Neighboring gene serpin family B member 3 Neighboring gene serpin family B member 7 Neighboring gene serpin family B member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC163242, MGC163244

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serpin B11
Names
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 11
serpin peptidase inhibitor, clade B (ovalbumin), member 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291278.2NP_001278207.1  serpin B11 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC069356, KF459701
    Consensus CDS
    CCDS77196.1
    UniProtKB/Swiss-Prot
    Q96P15
    UniProtKB/TrEMBL
    A0A096LPD5, A9UKE9
    Related
    ENSP00000485532.1, ENST00000623262.3
    Conserved Domains (1) summary
    cl00137
    Location:4305
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  2. NM_001291279.2NP_001278208.1  serpin B11 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC069356, KF459701
    UniProtKB/TrEMBL
    A9UKE9, B4DKT7
    Conserved Domains (1) summary
    cl00137
    Location:1217
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  3. NM_001370475.1NP_001357404.1  serpin B11 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC069356, KF459701
  4. NM_080475.4NP_536723.2  serpin B11 isoform a

    See identical proteins and their annotated locations for NP_536723.2

    Status: VALIDATED

    Source sequence(s)
    AC069356, KF459701
    UniProtKB/Swiss-Prot
    Q96P15
    UniProtKB/TrEMBL
    A9UKE9, F5GYW9
    Related
    ENSP00000421854.1, ENST00000382749.9
    Conserved Domains (1) summary
    cd02059
    Location:4392
    ovalbumin_like; The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

    Range
    63702304..63723893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526251.1XP_011524553.1  serpin B11 isoform X1

    UniProtKB/TrEMBL
    F5GYW9
    Related
    ENSP00000441497.1, ENST00000544088.5
    Conserved Domains (1) summary
    cd02059
    Location:4392
    ovalbumin_like; The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory ...
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