Slc22a7 solute carrier family 22 member 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc22a7provided by RGD
Official Full Name: solute carrier family 22 member 7provided by RGD
Primary source: RGD:621699
See related: Ensembl:ENSRNOG00000018420 AllianceGenome:RGD:621699
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Oat2; Livtr; rOAT2
Summary: Enables prostaglandin transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Involved in prostaglandin transport. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human SLC22A7 (solute carrier family 22 member 7). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Liver (RPKM 159.8) and Kidney (RPKM 85.8) See more
Orthologs: all
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Genomic context

Location:: 9q12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (22044672..22052051)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (14547073..14554354)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (16925321..16931119)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the findings revealed the important role of OAT2 in renal secretion and possible reabsorption of creatinine and suggested a molecular basis for potential species difference in the transporter handling of creatinine
Title: Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression.
strongly decreased expression of Oat2 and other transporters in female diabetic ZSF1 rats could possibly impair renal drug excretion, for example, of furosemide
Title: Sex-differences in renal expression of selected transporters and transcription factors in lean and obese Zucker spontaneously hypertensive fatty rats.
Expression of rat OAT2 in HEK (human embryonic kidney)-293 cells stimulates accumulation of the zwitterion trigonelline; subsequently, orotic acid is identified as an excellent and specific substrate of OAT2 from rat.
Title: OAT2 catalyses efflux of glutamate and uptake of orotic acid.
Oat2 mRNA expression was also highest in kidney rather than in liver. Considerably higher Oat2 levels were seen in female kidney as compared with male.
Title: Gender-specific and developmental influences on the expression of rat organic anion transporters.
In the zona glomerulosa and outer zona fasciculata. Oatp1-3 and OCT2 may be important for endocrine function of rat adrenocortical cells.
Title: Molecular evidence of organic ion transporters in the rat adrenal cortex with adrenocorticotropin-regulated zonal expression.
OAT2 in rat kidney exhibiting gender differences (F > M) that appear in puberty and are caused by strong androgen inhibition and weak estrogen and progesterone stimulation
Title: Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones.
induction of Oatp2 expression in liver of fasted mice may be caused by activation of the cAMP-dependent signaling pathway, with the CRE site (-1808/-1804) and CREB being the cis- and trans-acting factors mediating the induction, respectively
Title: Activation of cAMP-dependent signaling pathway induces mouse organic anion transporting polypeptide 2 expression.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-ketoglutarate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables alpha-ketoglutarate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables alpha-ketoglutarate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables prostaglandin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables secondary active transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alpha-ketoglutarate transport	IEA Inferred from Electronic Annotation more info
involved_in alpha-ketoglutarate transport	ISO Inferred from Sequence Orthology more info
involved_in alpha-ketoglutarate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in prostaglandin transport	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin transport	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin transport	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to stilbenoid	ISO Inferred from Sequence Orthology more info
involved_in sodium-independent organic anion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: solute carrier family 22 member 7

Names: Liver-specific transporter; novel liver transporter; organic anion transporter 2; solute carrier family 22 (organic anion transporter), member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053537.2 → NP_445989.2 solute carrier family 22 member 7

See identical proteins and their annotated locations for NP_445989.2

Status: PROVISIONAL

Source sequence(s)

AY816233

UniProtKB/Swiss-Prot

Q5RLM2, Q63314

UniProtKB/TrEMBL

A6JIQ9

Related

ENSRNOP00000025094.3, ENSRNOT00000025094.7

Conserved Domains (2) summary

cd06174
Location:144 → 511

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:11 → 521

2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

22044672..22052051

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084305.2 → XP_038940233.1 solute carrier family 22 member 7 isoform X2

Conserved Domains (1) summary

TIGR00898
Location:1 → 336

2A0119; cation transport protein
XM_039084304.2 → XP_038940232.1 solute carrier family 22 member 7 isoform X1

Conserved Domains (1) summary

TIGR00898
Location:38 → 427

2A0119; cation transport protein